LZTS2 leucine zipper tumor suppressor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LZTS2provided by HGNC
Official Full Name: leucine zipper tumor suppressor 2provided by HGNC
Primary source: HGNC:HGNC:29381
See related: Ensembl:ENSG00000107816 MIM:610454; AllianceGenome:HGNC:29381
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LAPSER1
Summary: The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression: Ubiquitous expression in endometrium (RPKM 12.4), fat (RPKM 11.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q24.31

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (100996588..101007833)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (101879963..101891208)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (102756345..102767590)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation of LZTS2 by PLK1 activates the Wnt pathway.
Title: Phosphorylation of LZTS2 by PLK1 activates the Wnt pathway.
LZTS2: A novel and independent prognostic biomarker for clear cell renal cell carcinoma.
Title: LZTS2: A novel and independent prognostic biomarker for clear cell renal cell carcinoma.
beta-Trcp and CK1delta-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
Title: β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
Study found that LZTS2 was downregulated in nasopharyngeal carcinoma patients and predicted poor prognosis. Functionally, we showed that LZTS2 suppresses tumorigenesis and radioresistance in nasopharyngeal carcinoma in a p85-dependent manner.
Title: LZTS2 inhibits PI3K/AKT activation and radioresistance in nasopharyngeal carcinoma by interacting with p85.
LZTS2 promoter hypermethylation is associated with laryngeal squamous cell carcinoma.
Title: LZTS2 promoter hypermethylation: a potential biomarker for the diagnosis and prognosis of laryngeal squamous cell carcinoma.
LZTS2 could inhibit cell proliferation and cell cycle transition at the G1/S phase and was implicated in the regulation of proteins associated with the canonical Wnt pathway, including GSK3B and beta-catenin through inactivating the Akt pathway.
Title: Leucine zipper tumor suppressor 2 inhibits cell proliferation and regulates Lef/Tcf-dependent transcription through Akt/GSK3β signaling pathway in lung cancer.
deletion of Lzts2 increases susceptibility to spontaneous and carcinogen-induced tumor development.
Title: Deletion of leucine zipper tumor suppressor 2 (Lzts2) increases susceptibility to tumor development.
LZTS2 is a beta-catenin-interacting protein and modulates beta-catenin signaling and localization
Title: LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin.
Observational study of gene-disease association. (HuGE Navigator)
Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
LAPSER1 C terminal domain inhibits katanin(p80/p60)-mediated microtubule severing in vitro.
Title: LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in microtubule severing	IEA Inferred from Electronic Annotation more info
involved_in mitotic cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to nucleus	IEA Inferred from Electronic Annotation more info
involved_in nuclear export	IEA Inferred from Electronic Annotation more info
involved_in primary ureteric bud growth	IEA Inferred from Electronic Annotation more info
involved_in spindle midzone assembly	IEA Inferred from Electronic Annotation more info
involved_in ureter morphogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: leucine zipper putative tumor suppressor 2

Names: leucine zipper, putative tumor suppressor 2; protein LAPSER1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001318099.2 → NP_001305028.1 leucine zipper putative tumor suppressor 2 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon and it thus differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 all encode the same isoform (a).

Source sequence(s)

AK298208, AL133215, BC006212, BC058938, HY037189

Consensus CDS

CCDS7507.1

UniProtKB/Swiss-Prot

B1AL14, D3DR72, Q8N3I0, Q96J79, Q96JL2, Q9BRK4

UniProtKB/TrEMBL

B4DP66

Conserved Domains (2) summary

COG1196
Location:329 → 537

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam06818
Location:439 → 636

Fez1
NM_001318100.2 → NP_001305029.1 leucine zipper putative tumor suppressor 2 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate 5' terminal exon and it thus differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 all encode the same isoform (a).

Source sequence(s)

AL133215, BC006212, BC058938, CN365632

Consensus CDS

CCDS7507.1

UniProtKB/Swiss-Prot

B1AL14, D3DR72, Q8N3I0, Q96J79, Q96JL2, Q9BRK4

UniProtKB/TrEMBL

B4DP66

Related

ENSP00000416972.2, ENST00000454422.2

Conserved Domains (2) summary

COG1196
Location:329 → 537

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam06818
Location:439 → 636

Fez1
NM_001318101.2 → NP_001305030.1 leucine zipper putative tumor suppressor 2 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. This variant has an incomplete 5' UTR because there are no 5'-complete transcripts representing it, and there is splicing ambiguity at the 5' end of the gene.

Source sequence(s)

AL133215

UniProtKB/Swiss-Prot

Q9BRK4

Conserved Domains (2) summary

pfam06818
Location:219 → 416

Fez1

pfam13851
Location:182 → 251

GAS; Growth-arrest specific micro-tubule binding
NM_001394944.1 → NP_001381873.1 leucine zipper putative tumor suppressor 2 isoform b

Status: REVIEWED

Source sequence(s)

AL133215

Conserved Domains (2) summary

pfam06818
Location:219 → 416

Fez1

pfam13851
Location:182 → 251

GAS; Growth-arrest specific micro-tubule binding
NM_001394945.1 → NP_001381874.1 leucine zipper putative tumor suppressor 2 isoform b

Status: REVIEWED

Source sequence(s)

AL133215

Conserved Domains (2) summary

pfam06818
Location:219 → 416

Fez1

pfam13851
Location:182 → 251

GAS; Growth-arrest specific micro-tubule binding
NM_001394946.1 → NP_001381875.1 leucine zipper putative tumor suppressor 2 isoform b

Status: REVIEWED

Source sequence(s)

AL133215

Conserved Domains (2) summary

pfam06818
Location:219 → 416

Fez1

pfam13851
Location:182 → 251

GAS; Growth-arrest specific micro-tubule binding
NM_001394947.1 → NP_001381876.1 leucine zipper putative tumor suppressor 2 isoform b

Status: REVIEWED

Source sequence(s)

AL133215

Conserved Domains (2) summary

pfam06818
Location:219 → 416

Fez1

pfam13851
Location:182 → 251

GAS; Growth-arrest specific micro-tubule binding
NM_001394948.1 → NP_001381877.1 leucine zipper putative tumor suppressor 2 isoform b

Status: REVIEWED

Source sequence(s)

AL133215

Conserved Domains (2) summary

pfam06818
Location:219 → 416

Fez1

pfam13851
Location:182 → 251

GAS; Growth-arrest specific micro-tubule binding
NM_001394949.1 → NP_001381878.1 leucine zipper putative tumor suppressor 2 isoform b

Status: REVIEWED

Source sequence(s)

AL133215

Conserved Domains (2) summary

pfam06818
Location:219 → 416

Fez1

pfam13851
Location:182 → 251

GAS; Growth-arrest specific micro-tubule binding
NM_001394950.1 → NP_001381879.1 leucine zipper putative tumor suppressor 2 isoform a

Status: REVIEWED

Source sequence(s)

AL133215

Consensus CDS

CCDS7507.1

UniProtKB/Swiss-Prot

B1AL14, D3DR72, Q8N3I0, Q96J79, Q96JL2, Q9BRK4

UniProtKB/TrEMBL

B4DP66

Conserved Domains (2) summary

COG1196
Location:329 → 537

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam06818
Location:439 → 636

Fez1
NM_001394951.1 → NP_001381880.1 leucine zipper putative tumor suppressor 2 isoform a

Status: REVIEWED

Source sequence(s)

AL133215

Consensus CDS

CCDS7507.1

UniProtKB/Swiss-Prot

B1AL14, D3DR72, Q8N3I0, Q96J79, Q96JL2, Q9BRK4

UniProtKB/TrEMBL

B4DP66

Conserved Domains (2) summary

COG1196
Location:329 → 537

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam06818
Location:439 → 636

Fez1
NM_001394952.1 → NP_001381881.1 leucine zipper putative tumor suppressor 2 isoform a

Status: REVIEWED

Source sequence(s)

AL133215

Consensus CDS

CCDS7507.1

UniProtKB/Swiss-Prot

B1AL14, D3DR72, Q8N3I0, Q96J79, Q96JL2, Q9BRK4

UniProtKB/TrEMBL

B4DP66

Conserved Domains (2) summary

COG1196
Location:329 → 537

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam06818
Location:439 → 636

Fez1
NM_032429.4 → NP_115805.1 leucine zipper putative tumor suppressor 2 isoform a

See identical proteins and their annotated locations for NP_115805.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2 and 3 all encode isoform a.

Source sequence(s)

AL133215, BC006212, HY039896

Consensus CDS

CCDS7507.1

UniProtKB/Swiss-Prot

B1AL14, D3DR72, Q8N3I0, Q96J79, Q96JL2, Q9BRK4

UniProtKB/TrEMBL

B4DP66

Related

ENSP00000359243.3, ENST00000370223.7

Conserved Domains (2) summary

COG1196
Location:329 → 537

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam06818
Location:439 → 636

Fez1