DRAXIN dorsal inhibitory axon guidance protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: DRAXINprovided by HGNC
Official Full Name: dorsal inhibitory axon guidance proteinprovided by HGNC
Primary source: HGNC:HGNC:25054
See related: Ensembl:ENSG00000162490 MIM:612682; AllianceGenome:HGNC:25054
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: UNQ3119; neucrin; AGPA3119; C1orf187
Summary: Enables molecular adaptor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and nervous system development. Predicted to act upstream of or within negative regulation of axon extension and negative regulation of hippocampal neuron apoptotic process. Predicted to be active in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (11686635..11725857)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (11230691..11269932)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (11751767..11785914)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DRAXIN as a Novel Diagnostic Marker to Predict the Poor Prognosis of Glioma Patients.
Title: DRAXIN as a Novel Diagnostic Marker to Predict the Poor Prognosis of Glioma Patients.
DRAXIN regulates interhemispheric fissure remodelling to influence the extent of corpus callosum formation.
Title: DRAXIN regulates interhemispheric fissure remodelling to influence the extent of corpus callosum formation.
results suggest that draxin functions as a repulsive guidance cue for PCN migration. However, we observed no significant differences in PCN distribution between draxin(-/-) and wild type embryos.
Title: Inhibitory effects of draxin on axonal outgrowth and migration of precerebellar neurons.
Neucrin is a unique secreted Wnt antagonist that is predominantly expressed in developing neural tissues.
Title: Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

AL009489 (e-PCR)
- UniSTS:83218

G60231 (e-PCR)
- UniSTS:137341

MARC_17073-17074:1023811913:3 (e-PCR)
- UniSTS:268208

MARC_17073-17074:1032539868:1 (e-PCR)
- UniSTS:268208

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables molecular adaptor activity	EXP Inferred from Experiment more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in anterior commissure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in commissural neuron differentiation in spinal cord	IBA Inferred from Biological aspect of Ancestor more info
involved_in commissural neuron differentiation in spinal cord	ISS Inferred from Sequence or Structural Similarity more info
involved_in dorsal spinal cord development	IBA Inferred from Biological aspect of Ancestor more info
involved_in dorsal spinal cord development	ISS Inferred from Sequence or Structural Similarity more info
involved_in forebrain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in forebrain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in hippocampal neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of axon extension	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of hippocampal neuron apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: draxin

Names: dorsal repulsive axon guidance protein; neural tissue-specific cysteine-rich protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.