SNCG synuclein gamma [Homo sapiens (human)] - Gene

Summary

Official Symbol: SNCGprovided by HGNC
Official Full Name: synuclein gammaprovided by HGNC
Primary source: HGNC:HGNC:11141
See related: Ensembl:ENSG00000173267 MIM:602998; AllianceGenome:HGNC:11141
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SR; BCSG1
Summary: This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010]
Expression: Biased expression in fat (RPKM 120.9), urinary bladder (RPKM 74.6) and 8 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q23.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (86955759..86963258)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (87839472..87846971)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (88715516..88723015)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer.
Title: Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer.
Effects of the Methylation Levels for the Breast Cancer Associated Genes BCSG1 and BRCA1 on Cellular Proliferation and Migration.
Title: Effects of the Methylation Levels for the Breast Cancer Associated Genes BCSG1 and BRCA1 on Cellular Proliferation and Migration.
Gamma synuclein promotes cancer metastasis through the MKK3/6-p38MAPK cascade.
Title: Gamma synuclein promotes cancer metastasis through the MKK3/6-p38MAPK cascade.
Upregulation of Synuclein-gamma and Snai1 Contributes to Poor Clinical Prognosis in Oral Squamous Cell Carcinoma Patients.
Title: Upregulation of Synuclein-γ and Snai1 Contributes to Poor Clinical Prognosis in Oral Squamous Cell Carcinoma Patients.
A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG.
Title: A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG.
Noninvasive Detection of Esophageal Cancer by the Combination of mSEPT9 and SNCG.
Title: Noninvasive Detection of Esophageal Cancer by the Combination of mSEPT9 and SNCG.
Suppression of synuclein gamma inhibits the movability of endometrial carcinoma cells by PI3K/AKT/ERK signaling pathway.
Title: Suppression of synuclein gamma inhibits the movability of endometrial carcinoma cells by PI3K/AKT/ERK signaling pathway.
Gamma-synuclein is a novel prognostic marker that promotes tumor cell migration in biliary tract carcinoma.
Title: Gamma-synuclein is a novel prognostic marker that promotes tumor cell migration in biliary tract carcinoma.
gamma-Synuclein is Closely Involved in Autophagy that Protects Colon Cancer Cell from Endoplasmic Reticulum Stress.
Title: γ-Synuclein is Closely Involved in Autophagy that Protects Colon Cancer Cell from Endoplasmic Reticulum Stress.
Silencing of BCSG1 with specific siRNA via nanocarriers for breast cancer treatment.
Title: Silencing of BCSG1 with specific siRNA via nanocarriers for breast cancer treatment.

Submit: New GeneRIF Correction See all GeneRIFs (96)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cuprous ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of dopamine secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurotransmitter secretion	IEA Inferred from Electronic Annotation more info
involved_in synapse organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gamma-synuclein

Names: -synuclein; E pound-synuclein; breast cancer-specific gene 1 protein; persyn; synoretin; synuclein, gamma (breast cancer-specific protein 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008783.1 RefSeqGene

Range

5069..9728

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001330120.2 → NP_001317049.1 gamma-synuclein isoform 2

Status: REVIEWED

Source sequence(s)

AC025268, BC014098, BG708703, EB388950

Consensus CDS

CCDS81483.1

UniProtKB/TrEMBL

F8W754

Related

ENSP00000344658.4, ENST00000348795.8

Conserved Domains (1) summary

pfam01387
Location:1 → 54

Synuclein; Synuclein
NM_003087.3 → NP_003078.2 gamma-synuclein isoform 1

Status: REVIEWED

Source sequence(s)

AK223367, BC014098

Consensus CDS

CCDS7380.1

UniProtKB/Swiss-Prot

O15104, O76070, Q96P61

UniProtKB/TrEMBL

A6NM47, Q6FHG5

Related

ENSP00000361087.3, ENST00000372017.4

Conserved Domains (1) summary

pfam01387
Location:1 → 110

Synuclein; Synuclein