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    ZDHHC21 zinc finger DHHC-type palmitoyltransferase 21 [ Homo sapiens (human) ]

    Gene ID: 340481, updated on 9-Dec-2024

    Summary

    Official Symbol
    ZDHHC21provided by HGNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 21provided by HGNC
    Primary source
    HGNC:HGNC:20750
    See related
    Ensembl:ENSG00000175893 MIM:614605; AllianceGenome:HGNC:20750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DNZ1; DHHC21; DHHC-21; HSPC097
    Summary
    Enables palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 3.1), skin (RPKM 2.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZDHHC21 in Genome Data Viewer
    Location:
    9p22.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (14588797..14693432, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (14598473..14703138, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (14611069..14693430, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene nuclear factor I B Neighboring gene uncharacterized LOC124902121 Neighboring gene uncharacterized LOC124902120 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:14547038-14547640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:14597299-14597830 Neighboring gene cell division cycle associated 4 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19776 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:14693435-14693935 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:14721879-14722818 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:14722819-14723756 Neighboring gene uncharacterized LOC105375979 Neighboring gene cerberus 1, DAN family BMP antagonist Neighboring gene FRAS1 related extracellular matrix 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Novel associations for hypothyroidism include known autoimmune risk loci.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • 9130404H11Rik

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables palmitoyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-cysteine S-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-cysteine S-palmitoyltransferase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in adrenergic receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hair follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nitric oxide metabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in peptidyl-L-cysteine S-palmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-L-cysteine S-palmitoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of establishment of endothelial barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of leukocyte adhesion to arterial endothelial cell ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of vascular associated smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sebaceous gland development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    palmitoyltransferase ZDHHC21
    Names
    DHHC domain-containing cysteine-rich protein 21
    zinc finger DHHC-type containing 21
    zinc finger, DHHC domain containing 21
    NP_001341047.1
    NP_001341048.1
    NP_001341049.1
    NP_001341050.1
    NP_001341051.1
    NP_001341052.1
    NP_001341053.1
    NP_001341054.1
    NP_001341055.1
    NP_001341056.1
    NP_001341057.1
    NP_001341058.1
    NP_001341059.1
    NP_848661.1
    XP_016870172.1
    XP_047279289.1
    XP_047279290.1
    XP_054218875.1
    XP_054218876.1
    XP_054218877.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001354118.2NP_001341047.1  palmitoyltransferase ZDHHC21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Consensus CDS
      CCDS6475.1
      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
      Conserved Domains (1) summary
      pfam01529
      Location:92217
      DHHC; DHHC palmitoyltransferase
    2. NM_001354119.2NP_001341048.1  palmitoyltransferase ZDHHC21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Consensus CDS
      CCDS6475.1
      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
      Conserved Domains (1) summary
      pfam01529
      Location:92217
      DHHC; DHHC palmitoyltransferase
    3. NM_001354120.2NP_001341049.1  palmitoyltransferase ZDHHC21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Consensus CDS
      CCDS6475.1
      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
      Conserved Domains (1) summary
      pfam01529
      Location:92217
      DHHC; DHHC palmitoyltransferase
    4. NM_001354121.2NP_001341050.1  palmitoyltransferase ZDHHC21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Consensus CDS
      CCDS6475.1
      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
      Conserved Domains (1) summary
      pfam01529
      Location:92217
      DHHC; DHHC palmitoyltransferase
    5. NM_001354122.2NP_001341051.1  palmitoyltransferase ZDHHC21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Consensus CDS
      CCDS6475.1
      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
      Conserved Domains (1) summary
      pfam01529
      Location:92217
      DHHC; DHHC palmitoyltransferase
    6. NM_001354123.2NP_001341052.1  palmitoyltransferase ZDHHC21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Consensus CDS
      CCDS6475.1
      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
      Conserved Domains (1) summary
      pfam01529
      Location:92217
      DHHC; DHHC palmitoyltransferase
    7. NM_001354124.2NP_001341053.1  palmitoyltransferase ZDHHC21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Consensus CDS
      CCDS6475.1
      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
      Conserved Domains (1) summary
      pfam01529
      Location:92217
      DHHC; DHHC palmitoyltransferase
    8. NM_001354125.2NP_001341054.1  palmitoyltransferase ZDHHC21 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Conserved Domains (1) summary
      pfam01529
      Location:63188
      zf-DHHC; DHHC palmitoyltransferase
    9. NM_001354126.2NP_001341055.1  palmitoyltransferase ZDHHC21 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Conserved Domains (1) summary
      pfam01529
      Location:63188
      zf-DHHC; DHHC palmitoyltransferase
    10. NM_001354127.2NP_001341056.1  palmitoyltransferase ZDHHC21 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Conserved Domains (1) summary
      pfam01529
      Location:2120
      DHHC; DHHC palmitoyltransferase
    11. NM_001354128.2NP_001341057.1  palmitoyltransferase ZDHHC21 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Conserved Domains (1) summary
      pfam01529
      Location:2120
      DHHC; DHHC palmitoyltransferase
    12. NM_001354129.2NP_001341058.1  palmitoyltransferase ZDHHC21 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Conserved Domains (1) summary
      pfam01529
      Location:2120
      DHHC; DHHC palmitoyltransferase
    13. NM_001354130.2NP_001341059.1  palmitoyltransferase ZDHHC21 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL390732
      Conserved Domains (1) summary
      pfam01529
      Location:2120
      DHHC; DHHC palmitoyltransferase
    14. NM_178566.6NP_848661.1  palmitoyltransferase ZDHHC21 isoform 1

      See identical proteins and their annotated locations for NP_848661.1

      Status: VALIDATED

      Source sequence(s)
      AK292960, AL390732
      Consensus CDS
      CCDS6475.1
      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
      Related
      ENSP00000370303.3, ENST00000380916.9
      Conserved Domains (1) summary
      pfam01529
      Location:92217
      DHHC; DHHC palmitoyltransferase

    RNA

    1. NR_148714.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL390732
    2. NR_148715.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL390732
    3. NR_148716.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL390732
    4. NR_148717.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL390732
    5. NR_148718.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL390732

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      14588797..14693432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014683.2XP_016870172.1  palmitoyltransferase ZDHHC21 isoform X1

      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
      Conserved Domains (1) summary
      pfam01529
      Location:92217
      DHHC; DHHC palmitoyltransferase
    2. XM_047423334.1XP_047279290.1  palmitoyltransferase ZDHHC21 isoform X1

      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
    3. XM_047423333.1XP_047279289.1  palmitoyltransferase ZDHHC21 isoform X1

      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6

    RNA

    1. XR_001746284.2 RNA Sequence

    2. XR_001746285.2 RNA Sequence

    3. XR_007061286.1 RNA Sequence

    4. XR_007061285.1 RNA Sequence

    5. XR_007061287.1 RNA Sequence

    6. XR_007061288.1 RNA Sequence

    7. XR_002956779.2 RNA Sequence

    8. XR_007061290.1 RNA Sequence

    9. XR_007061289.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      14598473..14703138 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362900.1XP_054218875.1  palmitoyltransferase ZDHHC21 isoform X1

      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
    2. XM_054362902.1XP_054218877.1  palmitoyltransferase ZDHHC21 isoform X1

      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
    3. XM_054362901.1XP_054218876.1  palmitoyltransferase ZDHHC21 isoform X1

      UniProtKB/Swiss-Prot
      A8KA95, D3DRI7, Q5VWG1, Q8IVQ6

    RNA

    1. XR_008488005.1 RNA Sequence

    2. XR_008488004.1 RNA Sequence

    3. XR_008488001.1 RNA Sequence

    4. XR_008488003.1 RNA Sequence

    5. XR_008488002.1 RNA Sequence

    6. XR_008488007.1 RNA Sequence

    7. XR_008488006.1 RNA Sequence

    8. XR_008488008.1 RNA Sequence

    9. XR_008488009.1 RNA Sequence

    10. XR_008488011.1 RNA Sequence

    11. XR_008488010.1 RNA Sequence