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    WDFY3-AS2 WDFY3 antisense RNA 2 [ Homo sapiens (human) ]

    Gene ID: 404201, updated on 10-Dec-2024

    Summary

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    Official Symbol
    WDFY3-AS2provided by HGNC
    Official Full Name
    WDFY3 antisense RNA 2provided by HGNC
    Primary source
    HGNC:HGNC:21603
    See related
    Ensembl:ENSG00000180769 AllianceGenome:HGNC:21603
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBI4; C4orf12; NCRNA00247
    Expression
    Broad expression in kidney (RPKM 6.9), brain (RPKM 4.7) and 17 other tissues See more
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    Genomic context

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    See WDFY3-AS2 in Genome Data Viewer
    Location:
    4q21.23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (84965616..85008743)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (88295634..88338762)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (85886769..85929896)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene WD repeat and FYVE domain containing 3 Neighboring gene WDFY3 antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:85777520-85778150 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:85791021-85791555 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:85791556-85792089 Neighboring gene RNA, U6 small nuclear 469, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:85848560-85849074 Neighboring gene RN7SK pseudogene 48 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:86087809-86088309 Neighboring gene quinone oxidoreductase-like protein 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Breakpoint analysis of the pericentric inversion distinguishing human chromosome 4 from the homologous chromosome in the chimpanzee (Pan troglodytes). Kehrer-Sawatzki H, et al. Hum Mutat, 2005 Jan. PMID 15580561
    2. Immunity-related long noncoding RNA WDFY3-AS2 inhibited cell proliferation and metastasis through Wnt/β-catenin signaling in oral squamous cell carcinoma. Lin X, et al. Arch Oral Biol, 2023 Mar. PMID 36657277
    3. LncRNA WDFY3-AS2 suppresses proliferation and invasion in oesophageal squamous cell carcinoma by regulating miR-2355-5p/SOCS2 axis. Zhang Q, et al. J Cell Mol Med, 2020 Jul. PMID 32536038, Free PMC Article
    4. In silico analyses identify lncRNAs: WDFY3-AS2, BDNF-AS and AFAP1-AS1 as potential prognostic factors for patients with triple-negative breast tumors. Rodrigues de Bastos D, et al. PLoS One, 2020. PMID 32401758, Free PMC Article
    5. USF1-induced overexpression of long noncoding RNA WDFY3-AS2 promotes lung adenocarcinoma progression via targeting miR-491-5p/ZNF703 axis. Ren P, et al. Mol Carcinog, 2020 Aug. PMID 32275336

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Immunity-related long noncoding RNA WDFY3-AS2 inhibited cell proliferation and metastasis through Wnt/beta-catenin signaling in oral squamous cell carcinoma.
      Title: Immunity-related long noncoding RNA WDFY3-AS2 inhibited cell proliferation and metastasis through Wnt/β-catenin signaling in oral squamous cell carcinoma.
    2. LncRNA WDFY3-AS2 suppresses proliferation and invasion in oesophageal squamous cell carcinoma by regulating miR-2355-5p/SOCS2 axis.
      Title: LncRNA WDFY3-AS2 suppresses proliferation and invasion in oesophageal squamous cell carcinoma by regulating miR-2355-5p/SOCS2 axis.
    3. USF1-induced overexpression of long noncoding RNA WDFY3-AS2 promotes lung adenocarcinoma progression via targeting miR-491-5p/ZNF703 axis.
      Title: USF1-induced overexpression of long noncoding RNA WDFY3-AS2 promotes lung adenocarcinoma progression via targeting miR-491-5p/ZNF703 axis.
    4. WDFY3-AS2, BDNF-AS and AFAP1-AS1 as potential prognostic factors for patients with triple-negative breast tumors
      Title: In silico analyses identify lncRNAs: WDFY3-AS2, BDNF-AS and AFAP1-AS1 as potential prognostic factors for patients with triple-negative breast tumors.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • WDFY3 antisense RNA 2 (non-protein coding)

    Clone Names

    • MGC120078, MGC120079

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_015359.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108021
      Related
      ENST00000652490.3

    2. NR_152771.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108021
      Related
      ENST00000652207.2

    3. NR_152772.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108021
      Related
      ENST00000652474.2

    4. NR_152773.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108021
      Related
      ENST00000650984.1

    5. NR_152774.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108021
      Related
      ENST00000651773.2

    6. NR_152775.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108021

    7. NR_152776.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108021, AY250185, BC019264, BC033127, BX104489, DA127567

    8. NR_152778.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108021
      Related
      ENST00000318186.8

    9. NR_152779.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108021
      Related
      ENST00000652312.2

    10. NR_152780.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108021
      Related
      ENST00000652652.2

    11. NR_152781.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108021
      Related
      ENST00000651209.1

    12. NR_152782.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108021
      Related
      ENST00000652610.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      84965616..85008743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      88295634..88338762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_205857.1: Suppressed sequence

      Description
      NM_205857.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate and encodes a protein of 99 amino acids that lacks homolog support.
    Nucleotide Protein
    Heading Accession and Version

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