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    ZNF579 zinc finger protein 579 [ Homo sapiens (human) ]

    Gene ID: 163033, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF579provided by HGNC
    Official Full Name
    zinc finger protein 579provided by HGNC
    Primary source
    HGNC:HGNC:26646
    See related
    Ensembl:ENSG00000218891 AllianceGenome:HGNC:26646
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney (RPKM 3.1), stomach (RPKM 2.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF579 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55576774..55580848, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58672701..58677500, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56088140..56092214, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56042573-56043073 Neighboring gene SH3 domain binding kinase family member 2 Neighboring gene Sharpr-MPRA regulatory region 3421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56056311-56057147 Neighboring gene Sharpr-MPRA regulatory region 14522 Neighboring gene SH3 domain binding kinase family member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56064283-56064783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11043 Neighboring gene Sharpr-MPRA regulatory region 13032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11045 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:56110254-56111128 Neighboring gene FLT3 interacting zinc finger 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:56111129-56112002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56113981-56114531 Neighboring gene zinc finger protein 524

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Analysis of proximal ALOX5 promoter binding proteins by quantitative proteomics. Schlag K, et al. FEBS J, 2020 Oct. PMID 32096311
    2. Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex. Spruijt CG, et al. FEBS J, 2021 May. PMID 33283408, Free PMC Article
    3. Genome-wide association study of chronic periodontitis in a general German population. Teumer A, et al. J Clin Periodontol, 2013 Nov. PMID 24024966
    4. The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer. Rengasamy M, et al. Nucleic Acids Res, 2017 Nov 2. PMID 28977470, Free PMC Article
    5. UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair. Huang Q, et al. FASEB J, 2022 Jan. PMID 34921745

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of chronic periodontitis in a general German population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat is identified to have a physical interaction with zinc finger protein 579 (ZNF579) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ35453

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 579

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152600.3 → NP_689813.2  zinc finger protein 579

      See identical proteins and their annotated locations for NP_689813.2

      Status: VALIDATED

      Source sequence(s)
      AC008735, AK092772, AW003562, CN340494, CX781546
      Consensus CDS
      CCDS12927.1
      UniProtKB/Swiss-Prot
      Q8NAF0
      Related
      ENSP00000320188.3, ENST00000325421.7
      Conserved Domains (3) summary
      COG5048
      Location:70 → 119
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:386 → 406
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:58 → 83
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      55576774..55580848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026411.3 → XP_016881900.1  zinc finger protein 579 isoform X3

    2. XM_017026410.3 → XP_016881899.1  zinc finger protein 579 isoform X2

    3. XM_017026409.3 → XP_016881898.1  zinc finger protein 579 isoform X1

    4. XM_047438318.1 → XP_047294274.1  zinc finger protein 579 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      58672701..58677500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320059.1 → XP_054176034.1  zinc finger protein 579 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NAF0.2 GenPept UniProtKB/Swiss-Prot:Q8NAF0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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