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    DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 [ Homo sapiens (human) ]

    Gene ID: 22826, updated on 27-Nov-2024

    Summary

    Official Symbol
    DNAJC8provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C8provided by HGNC
    Primary source
    HGNC:HGNC:15470
    See related
    Ensembl:ENSG00000126698 AllianceGenome:HGNC:15470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPF31; HSPC331
    Summary
    Enables Hsp70 protein binding activity. Located in cytosol; intercellular bridge; and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 41.4), endometrium (RPKM 36.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DNAJC8 in Genome Data Viewer
    Location:
    1p35.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (28200278..28233029, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (28042108..28074864, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28526789..28559540, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:28474708-28475208 Neighboring gene RNA, U7 small nuclear 29 pseudogene Neighboring gene platelet activating factor receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 587 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 535 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28559230-28559763 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:28561534-28562040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 591 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:28572195-28572694 Neighboring gene ATP synthase inhibitory factor subunit 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 593 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28576752-28577625 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 594 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:28585772-28586620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 537 Neighboring gene sestrin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human DnaJ (Hsp40) homolog, subfamily C, member 8 (DNAJC8) at amino acid residues 62-63 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Hsp70 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dnaJ homolog subfamily C member 8
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 8
    splicing protein spf31

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014280.3NP_055095.2  dnaJ homolog subfamily C member 8

      See identical proteins and their annotated locations for NP_055095.2

      Status: VALIDATED

      Source sequence(s)
      AL353354, DB294321
      Consensus CDS
      CCDS41292.1
      UniProtKB/Swiss-Prot
      B4DUU4, D3DPM0, O75937, Q6IBA4, Q8N4Z5, Q9P051, Q9P067
      Related
      ENSP00000263697.4, ENST00000263697.6
      Conserved Domains (2) summary
      cd06257
      Location:57112
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      COG2214
      Location:51238
      CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]

    RNA

    1. NR_159454.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL353354, AL353622
      Related
      ENST00000489277.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      28200278..28233029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654706.1 Reference GRCh38.p14 PATCHES

      Range
      1986..26673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      28042108..28074864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)