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    C6orf62 chromosome 6 open reading frame 62 [ Homo sapiens (human) ]

    Gene ID: 81688, updated on 27-Nov-2024

    Summary

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    Official Symbol
    C6orf62provided by HGNC
    Official Full Name
    chromosome 6 open reading frame 62provided by HGNC
    Primary source
    HGNC:HGNC:20998
    See related
    Ensembl:ENSG00000112308 AllianceGenome:HGNC:20998
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    XTP12; dJ30M3.2; Nbla00237
    Expression
    Ubiquitous expression in testis (RPKM 42.5), spleen (RPKM 41.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See C6orf62 in Genome Data Viewer
    Location:
    6p22.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (24704861..24720836, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (24575985..24592053, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (24705089..24721064, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901279 Neighboring gene acyl-CoA thioesterase 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:24682160-24682927 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:24682928-24683696 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:24683697-24684463 Neighboring gene uncharacterized LOC124901278 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:24699525-24699689 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:24720063-24720856 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:24721651-24722444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24157 Neighboring gene long intergenic non-protein coding RNA 2828 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:24754099-24754309 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:24758062-24758263 Neighboring gene AP3S1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24158 Neighboring gene geminin DNA replication inhibitor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. Simpson JC, et al. EMBO Rep, 2000 Sep. PMID 11256614, Free PMC Article
    2. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404
    3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Wiemann S, et al. Genome Res, 2001 Mar. PMID 11230166, Free PMC Article
    4. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
    5. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12619, DKFZp564G182

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein C6orf62
    Names
    HBV X-transactivated gene 12 protein
    HBV X-transactivated protein 12
    HBV XAg-transactivated protein 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410835.1 → NP_001397764.1  uncharacterized protein C6orf62 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL031775, AL133264
      Consensus CDS
      CCDS93869.1
      Related
      ENSP00000367342.3, ENST00000378102.3

    2. NM_030939.5 → NP_112201.1  uncharacterized protein C6orf62 isoform 1

      See identical proteins and their annotated locations for NP_112201.1

      Status: VALIDATED

      Source sequence(s)
      AL133264, BC040260, BC047866
      Consensus CDS
      CCDS4559.1
      UniProtKB/Swiss-Prot
      Q3LIB6, Q5JVZ2, Q5JVZ3, Q6IA63, Q9GZU0, Q9H1Z2
      Related
      ENSP00000367359.4, ENST00000378119.9
      Conserved Domains (1) summary
      pfam15130
      Location:1 → 226
      DUF4566; Domain of unknown function (DUF4566)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      24704861..24720836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419384.1 → XP_047275340.1  uncharacterized protein C6orf62 isoform X2

    2. XM_005249433.5 → XP_005249490.1  uncharacterized protein C6orf62 isoform X1

      Conserved Domains (1) summary
      pfam15130
      Location:1 → 143
      DUF4566; Domain of unknown function (DUF4566)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      24575985..24592053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356494.1 → XP_054212469.1  uncharacterized protein C6orf62 isoform X1

    2. XM_054356495.1 → XP_054212470.1  uncharacterized protein C6orf62 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GZU0.1 GenPept UniProtKB/Swiss-Prot:Q9GZU0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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