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    ZNF585A zinc finger protein 585A [ Homo sapiens (human) ]

    Gene ID: 199704, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF585Aprovided by HGNC
    Official Full Name
    zinc finger protein 585Aprovided by HGNC
    Primary source
    HGNC:HGNC:26305
    See related
    Ensembl:ENSG00000196967 AllianceGenome:HGNC:26305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Zfp27
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 3.0), testis (RPKM 2.5) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF585A in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37145540..37172695, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39820506..39847661, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37636442..37663597, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14537 Neighboring gene zinc finger protein 568 Neighboring gene zinc finger protein 420 Neighboring gene uncharacterized LOC105372390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14538 Neighboring gene Sharpr-MPRA regulatory region 11816 Neighboring gene zinc finger protein 585B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14540 Neighboring gene zinc finger protein 383

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
    2. A dual-activity topoisomerase complex regulates mRNA translation and turnover. Su S, et al. Nucleic Acids Res, 2022 Jul 8. PMID 35748872, Free PMC Article
    3. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
    4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23765, FLJ25829, FLJ31827

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 585A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001288800.2 → NP_001275729.1  zinc finger protein 585A isoform b

      See identical proteins and their annotated locations for NP_001275729.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longer isoform (b).
      Source sequence(s)
      AC012309, BC063820, DA990390
      Consensus CDS
      CCDS74353.1
      UniProtKB/Swiss-Prot
      Q6P3V2, Q8TE95, Q96MV3
      Related
      ENSP00000292841.7, ENST00000292841.10
      Conserved Domains (6) summary
      smart00349
      Location:27 → 85
      KRAB; krueppel associated box
      COG5048
      Location:184 → 529
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:496 → 516
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:328 → 347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:27 → 66
      KRAB; KRAB box
      pfam13465
      Location:705 → 728
      zf-H2C2_2; Zinc-finger double domain

    2. NM_152655.4 → NP_689868.1  zinc finger protein 585A isoform a

      See identical proteins and their annotated locations for NP_689868.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has an additional exon in the 5' region, which results in translation intiation at a downstream AUG, compared to variant 3. The resulting isoform (a) has a shorter N-terminus, compared to isoform b. Both variants 1 and 2 encode the same isoform a.
      Source sequence(s)
      AC012309, AK074345, DA738522, DA990390
      Consensus CDS
      CCDS12499.1
      UniProtKB/TrEMBL
      A0A0C4DFY4
      Related
      ENSP00000349440.3, ENST00000356958.8
      Conserved Domains (4) summary
      COG5048
      Location:129 → 474
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:441 → 461
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:273 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:650 → 673
      zf-H2C2_2; Zinc-finger double domain

    3. NM_199126.3 → NP_954577.1  zinc finger protein 585A isoform a

      See identical proteins and their annotated locations for NP_954577.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon and an additional exon in the 5' region, which results in translation intiation at a downstream AUG, compared to variant 3. The resulting isoform (a) has a shorter N-terminus, compared to isoform b. Both variants 1 and 2 encode the same isoform a.
      Source sequence(s)
      AC012309, BC052956, DB454691
      Consensus CDS
      CCDS12499.1
      UniProtKB/TrEMBL
      A0A0C4DFY4
      Related
      ENSP00000375998.1, ENST00000392157.2
      Conserved Domains (4) summary
      COG5048
      Location:129 → 474
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:441 → 461
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:273 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:650 → 673
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_110152.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks several exons and its transcription extends past a splice site that is used in variant 3. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AF086428, AW015367, DA990390
      Related
      ENST00000588354.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      37145540..37172695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      39820506..39847661 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P3V2.2 GenPept UniProtKB/Swiss-Prot:Q6P3V2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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