Rragb Ras-related GTP binding B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rragbprovided by MGI
Official Full Name: Ras-related GTP binding Bprovided by MGI
Primary source: MGI:MGI:3038613
See related: Ensembl:ENSMUSG00000041658 AllianceGenome:MGI:3038613
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable GTP binding activity; GTPase activity; and GTPase binding activity. Predicted to be involved in several processes, including cellular response to leucine starvation; negative regulation of autophagy; and positive regulation of TORC1 signaling. Predicted to be located in cytoplasm. Predicted to be part of Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosome and nucleus. Orthologous to human RRAGB (Ras related GTP binding B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 18.2), cerebellum adult (RPKM 16.5) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F3; X 68.46 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (151920640..151973188)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (153137644..153190192)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RagA and RagB are key regulators of lysosomal function and cardiac protection.
Title: Rag GTPases are cardioprotective by regulating lysosomal function.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase binding	IEA Inferred from Electronic Annotation more info
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables guanyl ribonucleotide binding	ISO Inferred from Sequence Orthology more info
enables guanyl ribonucleotide binding	ISS Inferred from Sequence or Structural Similarity more info
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to leucine starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to leucine starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of TOR signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Gtr1-Gtr2 GTPase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-related GTP-binding protein B

Names: rag B; ragB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004154.2 → NP_001004154.1 ras-related GTP-binding protein B

See identical proteins and their annotated locations for NP_001004154.1

Status: VALIDATED

Source sequence(s)

BC069180, BC070407, BY123210

Consensus CDS

CCDS30480.1

UniProtKB/Swiss-Prot

B1AVD6, Q6NTA4

Related

ENSMUSP00000039013.5, ENSMUST00000039720.11

Conserved Domains (1) summary

cd11384
Location:42 → 353

RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

151920640..151973188

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006528850.4 → XP_006528913.1 ras-related GTP-binding protein B isoform X2

Conserved Domains (1) summary

cd11384
Location:42 → 344

RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B
XM_036161969.1 → XP_036017862.1 ras-related GTP-binding protein B isoform X4

Conserved Domains (1) summary

cd11384
Location:42 → 316

RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B
XM_006528851.4 → XP_006528914.1 ras-related GTP-binding protein B isoform X3

Conserved Domains (1) summary

cd11384
Location:42 → 321

RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B
XM_006528849.5 → XP_006528912.1 ras-related GTP-binding protein B isoform X1

See identical proteins and their annotated locations for XP_006528912.1

Conserved Domains (1) summary

cd11384
Location:42 → 325

RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B
XM_030251348.1 → XP_030107208.1 ras-related GTP-binding protein B isoform X5

Conserved Domains (1) summary

cd11384
Location:42 → 293

RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B
XM_017318502.2 → XP_017173991.1 ras-related GTP-binding protein B isoform X6

Conserved Domains (1) summary

cl38936
Location:42 → 232

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases