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    COS1 6,7-dimethyl-8-ribityllumazine synthase / DMRL synthase / lumazine synthase / riboflavin synthase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819010, updated on 18-Sep-2024

    Summary

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    Official Symbol
    COS1
    Official Full Name
    6,7-dimethyl-8-ribityllumazine synthase / DMRL synthase / lumazine synthase / riboflavin synthase
    Primary source
    TAIR:AT2G44050
    Locus tag
    AT2G44050
    See related
    Araport:AT2G44050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    COI1 SUPPRESSOR1; coronatine insensitive1 suppressor; F6E13.18
    Summary
    6,7-dimethyl-8-ribityllumazine synthase / DMRL synthase / lumazine synthase / riboflavin synthase [Arabidopsis thaliana]. Acts in the jasmonic acid signaling pathway.
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    Genomic context

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    See COS1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (18224213..18226233)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene Dihydrodipicolinate reductase, bacterial/plant Neighboring gene Late embryogenesis abundant protein, group 2 Neighboring gene Ribosomal protein L2 family Neighboring gene NagB/RpiA/CoA transferase-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. COS1: an Arabidopsis coronatine insensitive1 suppressor essential for regulation of jasmonate-mediated plant defense and senescence. Xiao S, et al. Plant Cell, 2004 May. PMID 15075400, Free PMC Article
    2. Plant riboflavin biosynthesis. Cloning, chloroplast localization, expression, purification, and partial characterization of spinach lumazine synthase. Jordan DB, et al. J Biol Chem, 1999 Jul 30. PMID 10419541
    3. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701
    4. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article
    5. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_129967.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 6,7-dimethyl-8-ribityllumazine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 6,7-dimethyl-8-ribityllumazine synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within jasmonic acid mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in riboflavin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within riboflavin biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    part_of riboflavin synthase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    6,7-dimethyl-8-ribityllumazine synthase / DMRL synthase / lumazine synthase / riboflavin synthase
    NP_181933.1
    • COI1 SUPPRESSOR1 (COS1); FUNCTIONS IN: 6,7-dimethyl-8-ribityllumazine synthase activity; INVOLVED IN: riboflavin biosynthetic process, jasmonic acid mediated signaling pathway; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 6,7-dimethyl-8-ribityllumazine synthase (InterPro:IPR002180), 6,7-dimethyl-8-ribityllumazine synthase, chloroplast (InterPro:IPR017420); Has 7351 Blast hits to 7351 proteins in 2325 species: Archae - 190; Bacteria - 4938; Metazoa - 2; Fungi - 209; Plants - 81; Viruses - 0; Other Eukaryotes - 1931 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18224213..18226233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129967.4 → NP_181933.1  6,7-dimethyl-8-ribityllumazine synthase / DMRL synthase / lumazine synthase / riboflavin synthase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181933.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80575
      UniProtKB/TrEMBL
      A0A178VP65, A0A5S9X6U7, A0A7G2EHZ0
      Conserved Domains (1) summary
      PLN02404
      Location:78 → 218
      PLN02404; 6,7-dimethyl-8-ribityllumazine synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80575.1

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