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    GulLO2 D-arabinono-1,4-lactone oxidase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819288, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GulLO2
    Official Full Name
    D-arabinono-1,4-lactone oxidase family protein
    Primary source
    TAIR:AT2G46750
    Locus tag
    AT2G46750
    See related
    Araport:AT2G46750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    4-lactone ( L -GulL) oxidase 2; AtGulLO2; F19D11.3; L -gulono-1
    Summary
    Encodes a homolog of rat L-gulono-1,4-lactone (L-GulL) oxidase that is involved in the biosynthesis of L-ascorbic acid.
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    Genomic context

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    See GulLO2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (19207991..19211021, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene death domain associated protein Neighboring gene D-arabinono-1,4-lactone oxidase family protein Neighboring gene D-arabinono-1,4-lactone oxidase family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis thaliana Gulono-1,4 γ-lactone oxidase 2 (GULLO2) facilitates iron transport from endosperm into developing embryos and affects seed coat suberization. Murgia I, et al. Plant Physiol Biochem, 2023 Mar. PMID 36809732
    2. The contribution of Arabidopsis homologs of L-gulono-1,4-lactone oxidase to the biosynthesis of ascorbic acid. Maruta T, et al. Biosci Biotechnol Biochem, 2010. PMID 20622436
    3. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Arabidopsis thaliana Gulono-1,4 gamma-lactone oxidase 2 (GULLO2) facilitates iron transport from endosperm into developing embryos and affects seed coat suberization.
      Title: The Arabidopsis thaliana Gulono-1,4 γ-lactone oxidase 2 (GULLO2) facilitates iron transport from endosperm into developing embryos and affects seed coat suberization.
    Submit: New GeneRIF Correction

    General gene information

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    NM_130241.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables D-arabinono-1,4-lactone oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-gulonolactone oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-ascorbic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-ascorbic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-arabinono-1,4-lactone oxidase family protein
    NP_182198.2
    • D-arabinono-1,4-lactone oxidase family protein; FUNCTIONS IN: oxidoreductase activity, D-arabinono-1,4-lactone oxidase activity, FAD binding, catalytic activity; INVOLVED IN: oxidation reduction; LOCATED IN: membrane; EXPRESSED IN: hypocotyl, root; CONTAINS InterPro DOMAIN/s: D-arabinono-1,4-lactone oxidase (InterPro:IPR007173), FAD-binding, type 2 (InterPro:IPR016166), Plant-specific FAD-dependent oxidoreductase (InterPro:IPR010030), FAD linked oxidase, N-terminal (InterPro:IPR006094); BEST Arabidopsis thaliana protein match is: D-arabinono-1,4-lactone oxidase family protein (TAIR:AT2G46760.1); Has 2214 Blast hits to 2141 proteins in 703 species: Archae - 18; Bacteria - 1466; Metazoa - 84; Fungi - 192; Plants - 250; Viruses - 0; Other Eukaryotes - 204 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      19207991..19211021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130241.3 → NP_182198.2  D-arabinono-1,4-lactone oxidase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182198.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81031, Q0WNK2, Q6NQ66
      UniProtKB/TrEMBL
      A0A178VVH7, A0A5S9X7L1
      Conserved Domains (3) summary
      TIGR01677
      Location:29 → 582
      pln_FAD_oxido; plant-specific FAD-dependent oxidoreductase
      pfam01565
      Location:60 → 196
      FAD_binding_4; FAD binding domain
      cl21623
      Location:339 → 586
      ALO; D-arabinono-1,4-lactone oxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NQ66.1

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