CPN60A chaperonin-60alpha [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CPN60A
Official Full Name: chaperonin-60alpha
Primary source: TAIR:AT2G28000
Locus tag: AT2G28000
See related: Araport:AT2G28000
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: CH-CPN60A; chaperonin-60alpha; CHAPERONIN-60ALPHA; chaperonin-60alpha1; CHLOROPLAST CHAPERONIN 60ALPHA; Cpn60alpha1; SCHLEPPERLESS; SLP; T1E2.8; T1E2_8
Summary: Encodes chaperonin-60 alpha, a molecular chaperone involved in Rubisco folding. Mutants display aberrant chloroplast and embryo development.
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Genomic context

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See CPN60A in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 8

Sequence:: Chromosome: 2; NC_003071.7 (11926446..11929488)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the two Cpn60alpha subunits in Arabidopsis play different roles during embryo development through forming distinct chaperonins with specific AtCpn60beta to assist the folding of particular substrates
Title: Functional divergence of chloroplast Cpn60α subunits during Arabidopsis embryo development.
A null mutation in Cpn60-alpha abolished greening of plastids while a weaker mutation impairs plastid division.
Title: Plastid chaperonin proteins Cpn60 alpha and Cpn60 beta are required for plastid division in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_128359.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloroplast organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein folding	TAS Traceable Author Statement more info	PubMed
involved_in protein refolding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apoplast	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in chloroplast envelope	HDA more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in cytosolic ribosome	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in peroxisome	HDA more info	PubMed
located_in stromule	IDA Inferred from Direct Assay more info	PubMed
located_in thylakoid	HDA more info	PubMed

General protein information

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Preferred Names: chaperonin-60alpha

NP_180367.1

chaperonin-60alpha (CPN60A); FUNCTIONS IN: ATP binding; INVOLVED IN: protein folding, chloroplast organization, embryo development; LOCATED IN: in 8 components; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Chaperonin Cpn60/TCP-1 (InterPro:IPR002423), Chaperonin Cpn60, conserved site (InterPro:IPR018370), Chaperonin Cpn60 (InterPro:IPR001844); BEST Arabidopsis thaliana protein match is: TCP-1/cpn60 chaperonin family protein (TAIR:AT5G18820.1); Has 33896 Blast hits to 33887 proteins in 8716 species: Archae - 792; Bacteria - 21835; Metazoa - 1656; Fungi - 1573; Plants - 797; Viruses - 2; Other Eukaryotes - 7241 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

11926446..11929488

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128359.5 → NP_180367.1 chaperonin-60alpha [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180367.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P21238, Q42554, Q56WB8, Q8L5U4

UniProtKB/TrEMBL

A0A178VZW6, A0A5S9X1V8, A0A7G2EDL5

Conserved Domains (1) summary

cd03344
Location:49 → 569

GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...