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    E1 ALPHA pyruvate dehydrogenase complex E1 alpha subunit [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842284, updated on 18-Sep-2024

    Summary

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    Official Symbol
    E1 ALPHA
    Official Full Name
    pyruvate dehydrogenase complex E1 alpha subunit
    Primary source
    TAIR:AT1G59900
    Locus tag
    AT1G59900
    See related
    Araport:AT1G59900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AT-E1 ALPHA; pyruvate dehydrogenase complex E1 alpha subunit; PYRUVATE DEHYDROGENASE E1 ALPHA SUBUNIT
    Summary
    encodes the e1 alpha subunit of the pyruvate dehydrogenase complex (PDC)
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    Genomic context

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    See E1 ALPHA in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (22051133..22053885)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene SIN3-like 5 Neighboring gene Actin-binding FH2 (formin homology 2) family protein Neighboring gene MADS-box family protein Neighboring gene MADS-box family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Leaf proteome responses of Arabidopsis thaliana exposed to mild cadmium stress. Semane B, et al. J Plant Physiol, 2010 Mar 1. PMID 20005002
    2. Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolism. Lee CP, et al. Mol Cell Proteomics, 2008 Jul. PMID 18385124
    3. The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions. Zhang Y, et al. Plant Physiol, 2018 Jul. PMID 29794018, Free PMC Article
    4. Analysis of the Arabidopsis mitochondrial proteome. Millar AH, et al. Plant Physiol, 2001 Dec. PMID 11743115, Free PMC Article
    5. Proteomic analysis of the 26S proteasome reveals its direct interaction with transit peptides of plastid protein precursors for their degradation. Sako K, et al. J Proteome Res, 2014 Jul 3. PMID 24846764

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001333870.1
    NM_104682.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    pyruvate dehydrogenase complex E1 alpha subunit
    NP_176198.1
    • pyruvate dehydrogenase complex E1 alpha subunit (E1 ALPHA); FUNCTIONS IN: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, pyruvate dehydrogenase (acetyl-transferring) activity; INVOLVED IN: response to cadmium ion, metabolic process; LOCATED IN: cytosol, mitochondrion, nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Dehydrogenase, E1 component (InterPro:IPR001017), Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y (InterPro:IPR017597); BEST Arabidopsis thaliana protein match is: Thiamin diphosphate-binding fold (THDP-binding) superfamily protein (TAIR:AT1G24180.1); Has 9893 Blast hits to 9890 proteins in 1845 species: Archae - 125; Bacteria - 6023; Metazoa - 522; Fungi - 292; Plants - 213; Viruses - 0; Other Eukaryotes - 2718 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      22051133..22053885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104682.3 → NP_176198.1  pyruvate dehydrogenase complex E1 alpha subunit [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176198.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52901, Q9C5E3, Q9SXC2
      UniProtKB/TrEMBL
      A0A178WNY2, A0A5S9WR07
      Conserved Domains (1) summary
      PLN02269
      Location:28 → 389
      PLN02269; Pyruvate dehydrogenase E1 component subunit alpha

    2. NM_001333870.1 → NP_001321393.1  pyruvate dehydrogenase complex E1 alpha subunit [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AQS2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52901.2

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