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    AMT1;2 ammonium transporter 1;2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842786, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AMT1;2
    Official Full Name
    ammonium transporter 1;2
    Primary source
    TAIR:AT1G64780
    Locus tag
    AT1G64780
    See related
    Araport:AT1G64780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ammonium transporter 1;2; ATAMT1;2
    Summary
    encodes an ammonium transporter protein believed to act as a high affinity transporter. It is expressed in the root, primarily in endodermal and cortical cells, and contributes to ammonium uptake in the root.
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    Genomic context

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    See AMT1;2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (24060640..24062804, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene O-Glycosyl hydrolases family 17 protein Neighboring gene NDH-dependent cyclic electron flow 1 Neighboring gene ILITYHIA Neighboring gene uncharacterized protein Neighboring gene DNA binding / transcription factor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A twin histidine motif is the core structure for high-affinity substrate selection in plant ammonium transporters. Ganz P, et al. J Biol Chem, 2020 Mar 6. PMID 31988244, Free PMC Article
    2. A pore-occluding phenylalanine gate prevents ion slippage through plant ammonium transporters. Ganz P, et al. Sci Rep, 2019 Nov 14. PMID 31727964, Free PMC Article
    3. The organization of high-affinity ammonium uptake in Arabidopsis roots depends on the spatial arrangement and biochemical properties of AMT1-type transporters. Yuan L, et al. Plant Cell, 2007 Aug. PMID 17693533, Free PMC Article
    4. HY5 regulates nitrite reductase 1 (NIR1) and ammonium transporter1;2 (AMT1;2) in Arabidopsis seedlings. Huang L, et al. Plant Sci, 2015 Sep. PMID 26259199, Free PMC Article
    5. Nematode-induced changes of transporter gene expression in Arabidopsis roots. Hammes UZ, et al. Mol Plant Microbe Interact, 2005 Dec. PMID 16478044

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A pore-occluding phenylalanine gate prevents ion slippage through plant ammonium transporters.
      Title: A pore-occluding phenylalanine gate prevents ion slippage through plant ammonium transporters.
    2. A twin histidine motif is the core structure for high-affinity substrate selection in plant ammonium transporters.
      Title: A twin histidine motif is the core structure for high-affinity substrate selection in plant ammonium transporters.
    3. HY5 positively regulates nitrite reductase gene NIR1 and negatively regulates the ammonium transporter gene AMT1;2 under all nitrogen and light conditions tested.
      Title: HY5 regulates nitrite reductase 1 (NIR1) and ammonium transporter1;2 (AMT1;2) in Arabidopsis seedlings.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_105152.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ammonium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ammonium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylammonium transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to nematode HEP PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ammonium transporter 1;2
    NP_176658.1
    • ammonium transporter 1;2 (AMT1;2); CONTAINS InterPro DOMAIN/s: Ammonium transporter (InterPro:IPR001905), Ammonium transporter, conserved site (InterPro:IPR018047); BEST Arabidopsis thaliana protein match is: ammonium transporter 1;1 (TAIR:AT4G13510.1); Has 11676 Blast hits to 11662 proteins in 2073 species: Archae - 224; Bacteria - 4692; Metazoa - 520; Fungi - 427; Plants - 507; Viruses - 0; Other Eukaryotes - 5306 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24060640..24062804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105152.3 → NP_176658.1  ammonium transporter 1;2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176658.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SQH8, Q9ZPJ8
      UniProtKB/TrEMBL
      A0A178WB01, A0A5S9WPC1
      Conserved Domains (1) summary
      TIGR00836
      Location:53 → 479
      amt; ammonium transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZPJ8.1

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