ATHSRP54A signal recognition particle 54 kDa subunit [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ATHSRP54A
Official Full Name: signal recognition particle 54 kDa subunit
Primary source: TAIR:AT1G15310
Locus tag: AT1G15310
See related: Araport:AT1G15310
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F9L1.25; F9L1_25; signal recognition particle 54 kDa subunit; SIGNAL RECOGNITION PARTICLE 54 KDA SUBUNIT; SRP54-1
Summary: 54 kDa protein subunit of SRP that interacts with the signal peptide of secreted proteins
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Genomic context

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See ATHSRP54A in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 9

Sequence:: Chromosome: 1; NC_003070.9 (5268891..5272058, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The inability of Arabidopsis thaliana cpSRP54 to bind bacterial signal recognition particle-RNA is caused by two amino acid substitutions in the otherwise conserved RNA binding domain.
Title: Evolutionary substitution of two amino acids in chloroplast SRP54 of higher plants cause its inability to bind SRP RNA.
These results highlight intriguing differences between the classical and chloroplast SRP and SRP receptor GTPases, and help explain how the chloroplast SRP pathway can mediate efficient targeting of proteins to the thylakoid membrane.
Title: Efficient interaction between two GTPases allows the chloroplast SRP pathway to bypass the requirement for an SRP RNA.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_101400.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 7S RNA binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of signal recognition particle, endoplasmic reticulum targeting	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: signal recognition particle 54 kDa subunit

NP_563970.1

signal recognition particle 54 kDa subunit (ATHSRP54A); FUNCTIONS IN: 7S RNA binding, mRNA binding, nucleoside-triphosphatase activity, GTP binding, nucleotide binding; INVOLVED IN: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, SRP-dependent cotranslational protein targeting to membrane; LOCATED IN: signal recognition particle, endoplasmic reticulum targeting, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), Signal recognition particle, SRP54 subunit, helical bundle (InterPro:IPR013822), Signal recognition particle, SRP54 subunit, M-domain (InterPro:IPR004125), Signal recognition particle, SRP54 subunit, GTPase (InterPro:IPR000897), Signal recognition particle, SRP54 subunit (InterPro:IPR006325); BEST Arabidopsis thaliana protein match is: Signal recognition particle, SRP54 subunit protein (TAIR:AT1G48900.1); Has 17558 Blast hits to 17547 proteins in 2928 species: Archae - 474; Bacteria - 10612; Metazoa - 362; Fungi - 294; Plants - 285; Viruses - 1; Other Eukaryotes - 5530 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

5268891..5272058 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101400.4 → NP_563970.1 signal recognition particle 54 kDa subunit [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_563970.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P37106

UniProtKB/TrEMBL

A0A178WDC9, A0A654EBM1, Q56XJ0

Conserved Domains (1) summary

TIGR01425
Location:2 → 426

SRP54_euk; signal recognition particle protein SRP54