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    3-beta hydroxysteroid dehydrogenase/isomerase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818943, updated on 14-Nov-2024

    Summary

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    Official Full Name
    3-beta hydroxysteroid dehydrogenase/isomerase family protein
    Primary source
    TAIR:AT2G43420
    Locus tag
    AT2G43420
    See related
    Araport:AT2G43420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T1O24.16
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    12
    Sequence:
    Chromosome: 2; NC_003071.7 (18031268..18035182, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene electron-transfer flavoprotein:ubiquinone oxidoreductase Neighboring gene ncRNA Neighboring gene RNA binding protein Neighboring gene glyoxalase 2-1 Neighboring gene F-box and associated interaction domains-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The odd one out: Arabidopsis reticulon 20 does not bend ER membranes but has a role in lipid regulation. Kriechbaumer V, et al. Sci Rep, 2018 Feb 2. PMID 29396477, Free PMC Article
    2. Arabidopsis plasmodesmal proteome. Fernandez-Calvino L, et al. PLoS One, 2011 Apr 20. PMID 21533090, Free PMC Article
    3. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_129903.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [NAD(+)] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    3-beta hydroxysteroid dehydrogenase/isomerase family protein
    NP_565998.1
    • 3-beta hydroxysteroid dehydrogenase/isomerase family protein; FUNCTIONS IN: binding, 3-beta-hydroxy-delta5-steroid dehydrogenase activity, catalytic activity; INVOLVED IN: steroid biosynthetic process, metabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Reticulon (InterPro:IPR003388), 3-beta hydroxysteroid dehydrogenase/isomerase (InterPro:IPR002225), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2 (TAIR:AT2G26260.1); Has 10307 Blast hits to 10296 proteins in 2122 species: Archae - 301; Bacteria - 6803; Metazoa - 545; Fungi - 280; Plants - 752; Viruses - 81; Other Eukaryotes - 1545 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18031268..18035182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129903.3 → NP_565998.1  3-beta hydroxysteroid dehydrogenase/isomerase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565998.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9X4U2, O22856, Q94AR9
      UniProtKB/TrEMBL
      A0A178W0W0, A0A5S9X6X5
      Conserved Domains (2) summary
      cd09813
      Location:14 → 354
      3b-HSD-NSDHL-like_SDR_e; human NSDHL (NAD(P)H steroid dehydrogenase-like protein)-like, extended (e) SDRs
      pfam02453
      Location:379 → 537
      Reticulon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A9X4U2.2

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