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    WPP2 WPP domain protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841123, updated on 18-Sep-2024

    Summary

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    Official Symbol
    WPP2
    Official Full Name
    WPP domain protein 2
    Primary source
    TAIR:AT1G47200
    Locus tag
    AT1G47200
    See related
    Araport:AT1G47200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F2G19.18; F2G19_18; WPP domain protein 2
    Summary
    WPP family members contains an NE targeting domain. This domain, called the WPP domain after a highly conserved Trp-Pro-Pro motif, is necessary for NE targeting of WPP1. RNAi suppression of WPP2 resulted in reduced mitotic activity.
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    Genomic context

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    See WPP2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (17297831..17298829, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene cyclin-dependent protein kinase 3;2 Neighboring gene Cyclin A3;3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis WPP-domain proteins are developmentally associated with the nuclear envelope and promote cell division. Patel S, et al. Plant Cell, 2004 Dec. PMID 15548735, Free PMC Article
    2. Two distinct interacting classes of nuclear envelope-associated coiled-coil proteins are required for the tissue-specific nuclear envelope targeting of Arabidopsis RanGAP. Zhao Q, et al. Plant Cell, 2008 Jun. PMID 18591351, Free PMC Article
    3. WPP-domain proteins mimic the activity of the HSC70-1 chaperone in preventing mistargeting of RanGAP1-anchoring protein WIT1. Brkljacic J, et al. Plant Physiol, 2009 Sep. PMID 19617588, Free PMC Article
    4. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_103613.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lateral root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    WPP domain protein 2
    NP_564498.1
    • WPP domain protein 2 (WPP2); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: mitosis, lateral root development; LOCATED IN: plasma membrane, nuclear outer membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; BEST Arabidopsis thaliana protein match is: WPP domain protein 1 (TAIR:AT5G43070.1); Has 150 Blast hits to 150 proteins in 29 species: Archae - 0; Bacteria - 0; Metazoa - 8; Fungi - 5; Plants - 136; Viruses - 0; Other Eukaryotes - 1 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      17297831..17298829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103613.3 → NP_564498.1  WPP domain protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564498.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LE13, Q9C500
      UniProtKB/TrEMBL
      A0A178WLI8, A0A5S9WMQ4
      Conserved Domains (1) summary
      pfam13943
      Location:58 → 148
      WPP; WPP domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C500.1

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