IVD isovaleryl-CoA-dehydrogenase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: IVD
Official Full Name: isovaleryl-CoA-dehydrogenase
Primary source: TAIR:AT3G45300
Locus tag: AT3G45300
See related: Araport:AT3G45300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATIVD; isovaleryl-CoA-dehydrogenase; ISOVALERYL-COA-DEHYDROGENASE; ISOVALERYL-COA-DEHYDROGENASE PRECURSOR; IVDH
Summary: Encodes isovaleryl-coenzyme a dehydrogenase. Mutants have increases in 12 seed free amino acids, accumulation of seed homomethionine and 3-isovaleroyloxypropyl-glucosinolate, with a concomitant decrease in seed 3-benzoyloxypropyl-glucosinolate.
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Genomic context

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See IVD in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 15

Sequence:: Chromosome: 3; NC_003074.8 (16621452..16625043, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data elucidates the pathway of plant Lys catabolism and demonstrate that both isovaleryl-CoA dehydrogenase and 2-hydroxyglutarate dehydrogenase act as electron donors to the ubiquinol pool via an ETF/ETFQO-mediated route. [IVDH]
Title: Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria.
Accumulation of both homomethionine and 3-isovaleroyloxypropyl-glucosinolate cosegregates with the high branched chain amino acid phenotype in IVD mutants.
Title: Broad connections in the Arabidopsis seed metabolic network revealed by metabolite profiling of an amino acid catabolism mutant.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_114399.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 3-methylbutanoyl-CoA dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-methylbutanoyl-CoA dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ATP binding	HDA more info	PubMed
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within L-leucine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in L-leucine catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within L-leucine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within alternative respiration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branched-chain amino acid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: isovaleryl-CoA-dehydrogenase

NP_190116.1

isovaleryl-CoA-dehydrogenase (IVD); FUNCTIONS IN: isovaleryl-CoA dehydrogenase activity, ATP binding; INVOLVED IN: leucine catabolic process; LOCATED IN: mitochondrion, mitochondrial matrix; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal (InterPro:IPR013764), Acyl-CoA oxidase/dehydrogenase, type 1 (InterPro:IPR006090), Acyl-CoA dehydrogenase/oxidase, N-terminal (InterPro:IPR013786), Acyl-CoA dehydrogenase/oxidase (InterPro:IPR009100), Acyl-CoA oxidase/dehydrogenase, central domain (InterPro:IPR006091), Acyl-CoA dehydrogenase, conserved site (InterPro:IPR006089), Acyl-CoA dehydrogenase/oxidase C-terminal (InterPro:IPR009075), Acyl-CoA dehydrogenase, N-terminal (InterPro:IPR006092); BEST Arabidopsis thaliana protein match is: acyl-CoA oxidase 4 (TAIR:AT3G51840.1); Has 45583 Blast hits to 45129 proteins in 2067 species: Archae - 559; Bacteria - 29477; Metazoa - 1687; Fungi - 835; Plants - 308; Viruses - 0; Other Eukaryotes - 12717 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

16621452..16625043 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_114399.5 → NP_190116.1 isovaleryl-CoA-dehydrogenase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_190116.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8W4G7, Q9SWG0, Q9XFT2

UniProtKB/TrEMBL

A0A178VF82, A0A5S9XI16, Q0WPE4

Conserved Domains (2) summary

cd01156
Location:32 → 407

IVD; Isovaleryl-CoA dehydrogenase

PLN02519
Location:32 → 409

PLN02519; isovaleryl-CoA dehydrogenase