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    HEXO1 beta-hexosaminidase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824692, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HEXO1
    Official Full Name
    beta-hexosaminidase 1
    Primary source
    TAIR:AT3G55260
    Locus tag
    AT3G55260
    See related
    Araport:AT3G55260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATHEX2; beta-hexosaminidase 1
    Summary
    Encodes a protein with beta-hexosaminidase activity (the enzyme is active with p-nitrophenyl-beta-N-acetylglucosaminide as substrate but displayed only a minor activity toward p-nitrophenyl-beta-N-acetylgalactosaminide). The enzyme displays no distinct preference for a specific terminal GlcNAc residue and indeed cleaved the asialoagalactodabsylglycopeptide GnGn to a mixture of products.
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    Genomic context

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    See HEXO1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    15
    Sequence:
    Chromosome: 3; NC_003074.8 (20489096..20493096)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Plant self-incompatibility protein S1 family Neighboring gene miscRNA Neighboring gene mitogen-activated protein kinase phosphatase 1 Neighboring gene ribosomal protein L23AB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Beta-N-acetylhexosaminidases HEXO1 and HEXO3 are responsible for the formation of paucimannosidic N-glycans in Arabidopsis thaliana. Liebminger E, et al. J Biol Chem, 2011 Mar 25. PMID 21252225, Free PMC Article
    2. Enzymatic properties and subcellular localization of Arabidopsis beta-N-acetylhexosaminidases. Strasser R, et al. Plant Physiol, 2007 Sep. PMID 17644627, Free PMC Article
    3. Biosynthesis of truncated N-linked oligosaccharides results from non-orthologous hexosaminidase-mediated mechanisms in nematodes, plants, and insects. Gutternigg M, et al. J Biol Chem, 2007 Sep 21. PMID 17636254, Free PMC Article
    4. Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana. Shimaoka T, et al. Plant Cell Physiol, 2004 Jun. PMID 15215502
    5. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Beta-N-acetylhexosaminidases HEXO1 and HEXO3 are responsible for the formation of paucimannosidic N-glycans in Arabidopsis thaliana.
      Title: Beta-N-acetylhexosaminidases HEXO1 and HEXO3 are responsible for the formation of paucimannosidic N-glycans in Arabidopsis thaliana.
    2. participates in N-glycan trimming in the vacuole, capable of removing terminal GlcNAc residues from the alpha1,3- and alpha1,6-mannosyl branches of biantennary N-glycans without any strict branch preference
      Title: Enzymatic properties and subcellular localization of Arabidopsis beta-N-acetylhexosaminidases.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_115384.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables beta-N-acetylhexosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hexosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-glycan processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in secretory vesicle HDA PubMed 
    located_in vacuole HDA PubMed 
    located_in vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-hexosaminidase 1
    NP_567017.2
    • beta-hexosaminidase 1 (HEXO1); FUNCTIONS IN: hexosaminidase activity, beta-N-acetylhexosaminidase activity, hydrolase activity, hydrolyzing O-glycosyl compounds; INVOLVED IN: carbohydrate metabolic process; LOCATED IN: vacuole, plant-type cell wall; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glycoside hydrolase, family 20, catalytic core (InterPro:IPR015883), Beta-N-acetylhexosaminidase, subunit a/b (InterPro:IPR015882), Glycoside hydrolase, catalytic core (InterPro:IPR017853), Glycoside hydrolase, family 20 (InterPro:IPR001540), Glycoside hydrolase, subgroup, catalytic core (InterPro:IPR013781); BEST Arabidopsis thaliana protein match is: beta-hexosaminidase 3 (TAIR:AT1G65590.1); Has 3779 Blast hits to 3705 proteins in 735 species: Archae - 2; Bacteria - 2420; Metazoa - 475; Fungi - 222; Plants - 128; Viruses - 0; Other Eukaryotes - 532 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20489096..20493096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115384.4 → NP_567017.2  beta-hexosaminidase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567017.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7WM73, Q0WUA8, Q8LFK0, Q9M3C5
      UniProtKB/TrEMBL
      A0A178VFV1, A0A5S9XKZ4
      Conserved Domains (2) summary
      cd06562
      Location:185 → 517
      GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...
      pfam14845
      Location:33 → 160
      Glycohydro_20b2; beta-acetyl hexosaminidase like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A7WM73.1

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