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    WNK8 with no lysine (K) kinase 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834204, updated on 18-Sep-2024

    Summary

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    Official Symbol
    WNK8
    Official Full Name
    with no lysine (K) kinase 8
    Primary source
    TAIR:AT5G41990
    Locus tag
    AT5G41990
    See related
    Araport:AT5G41990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATWNK8; EIP1; EMF1-Interacting Protein 1; MJC20.9; MJC20_9; with no lysine (K) kinase 8
    Summary
    Encodes a member of the WNK family (9 members in all) of protein kinases, the structural design of which is clearly distinct from those of other known protein kinases, such as receptor-like kinases and mitogen-activated protein kinases. Interacts specifically with and phosphorylates AtVHA-C, subunit C of the vacuolar H+-ATPase.
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    Genomic context

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    See WNK8 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (16794967..16798006, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene zinc finger matrin-type protein Neighboring gene Metal-dependent protein hydrolase Neighboring gene nuclease Neighboring gene ORMDL family protein Neighboring gene Transducin/WD40 repeat-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modulation of ABA responses by the protein kinase WNK8. Waadt R, et al. FEBS Lett, 2019 Feb. PMID 30556127
    2. Disruption of AtWNK8 enhances tolerance of Arabidopsis to salt and osmotic stresses via modulating proline content and activities of catalase and peroxidase. Zhang B, et al. Int J Mol Sci, 2013 Mar 27. PMID 23535337, Free PMC Article
    3. Co-option of EDM2 to distinct regulatory modules in Arabidopsis thaliana development. Tsuchiya T, et al. BMC Plant Biol, 2010 Sep 14. PMID 20840782, Free PMC Article
    4. The Arabidopsis defense component EDM2 affects the floral transition in an FLC-dependent manner. Tsuchiya T, et al. Plant J, 2010 May. PMID 20149132
    5. A WNK kinase binds and phosphorylates V-ATPase subunit C. Hong-Hermesdorf A, et al. FEBS Lett, 2006 Feb 6. PMID 16427632

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WNK8 functions as a negative modulator of ABA signaling.
      Title: Modulation of ABA responses by the protein kinase WNK8.
    2. RACK1 is phosphorylated by WNK8.
      Title: Arabidopsis receptor of activated C kinase1 phosphorylation by WITH NO LYSINE8 KINASE.
    3. maintaining higher CAT and POD activities might be one of the reasons that the disruption of AtWNK8 enhances the tolerance to salt stress.
      Title: Disruption of AtWNK8 enhances tolerance of Arabidopsis to salt and osmotic stresses via modulating proline content and activities of catalase and peroxidase.
    4. WNK8 can modulate the activity of EDM2.
      Title: Co-option of EDM2 to distinct regulatory modules in Arabidopsis thaliana development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Miscellaneous features

    • Loc: c16797907-16797698 AT5G41990.uORF1
    NM_123564.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within photoperiodism, flowering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    with no lysine (K) kinase 8
    NP_568599.1
    • with no lysine (K) kinase 8 (WNK8); CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: with no lysine (K) kinase 10 (TAIR:AT1G64630.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      16794967..16798006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123564.3 → NP_568599.1  with no lysine (K) kinase 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568599.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S8Y7, Q944Q0, Q9FHY4
      UniProtKB/TrEMBL
      A0A5S9YAC1
      Conserved Domains (2) summary
      smart00220
      Location:33 → 286
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13983
      Location:27 → 286
      STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q944Q0.1

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