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    formyltetrahydrofolate deformylase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834791, updated on 18-Sep-2024

    Summary

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    Official Full Name
    formyltetrahydrofolate deformylase
    Primary source
    TAIR:AT5G47435
    Locus tag
    AT5G47435
    See related
    Araport:AT5G47435
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Summary
    encodes one of the two putative formyltetrahydrofolate deformylase. Located in the mitochondrion. Involved in photorespiratory tetrahydrofolate cycle.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (19241672..19243988)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Tryptophan RNA-binding attenuator protein-like protein Neighboring gene DWNN domain, a CCHC-type zinc finger Neighboring gene auxin canalization protein (DUF828) Neighboring gene pseudo Neighboring gene tonoplast intrinsic protein 2;3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis 10-formyl tetrahydrofolate deformylases are essential for photorespiration. Collakova E, et al. Plant Cell, 2008 Jul. PMID 18628352, Free PMC Article
    2. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_124115.4
    NM_180814.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables formyltetrahydrofolate deformylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within photorespiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tetrahydrofolate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    formyltetrahydrofolate deformylase
    NP_568682.1
    • formyltetrahydrofolate deformylase, putative; FUNCTIONS IN: hydroxymethyl-, formyl- and related transferase activity, formyltetrahydrofolate deformylase activity; INVOLVED IN: tetrahydrofolate metabolic process, purine ribonucleotide biosynthetic process, biosynthetic process, photorespiration; LOCATED IN: mitochondrion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Formyltetrahydrofolate deformylase (InterPro:IPR004810), Formyl transferase, N-terminal (InterPro:IPR002376); BEST Arabidopsis thaliana protein match is: Formyl transferase (TAIR:AT4G17360.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_851145.1
    • formyltetrahydrofolate deformylase, putative; FUNCTIONS IN: hydroxymethyl-, formyl- and related transferase activity, formyltetrahydrofolate deformylase activity; INVOLVED IN: tetrahydrofolate metabolic process, purine ribonucleotide biosynthetic process, biosynthetic process, photorespiration; LOCATED IN: mitochondrion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Formyltetrahydrofolate deformylase (InterPro:IPR004810), Formyl transferase, N-terminal (InterPro:IPR002376); BEST Arabidopsis thaliana protein match is: Formyl transferase (TAIR:AT4G17360.1); Has 14552 Blast hits to 14552 proteins in 2615 species: Archae - 121; Bacteria - 10332; Metazoa - 171; Fungi - 86; Plants - 154; Viruses - 3; Other Eukaryotes - 3685 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19241672..19243988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124115.4 → NP_568682.1  formyltetrahydrofolate deformylase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568682.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93YQ3
      UniProtKB/TrEMBL
      A0A178UR78, A0A5S9YBU2, A0A7G2FI84
      Conserved Domains (1) summary
      PLN02828
      Location:56 → 323
      PLN02828; formyltetrahydrofolate deformylase

    2. NM_180814.3 → NP_851145.1  formyltetrahydrofolate deformylase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851145.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93YQ3
      UniProtKB/TrEMBL
      A0A178UR78, A0A5S9YBU2, A0A7G2FI84
      Conserved Domains (1) summary
      PLN02828
      Location:56 → 323
      PLN02828; formyltetrahydrofolate deformylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93YQ3.1

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