UVR8 Regulator of chromosome condensation (RCC1) family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: UVR8
Official Full Name: Regulator of chromosome condensation (RCC1) family protein
Primary source: TAIR:AT5G63860
Locus tag: AT5G63860
See related: Araport:AT5G63860
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: MGI19.7; MGI19_7; UVB-RESISTANCE 8
Summary: UV-B-specific signaling component that orchestrates expression of a range of genes with vital UV-protective functions. Located in the nucleus and the cytosol. Associates with chromatin via histones. UV-B light promotes URV8 protein accumulation in the nucleus. UVR8 interaction with COP1 is negatively regulated by RUP1 and RUP2.
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Genomic context

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See UVR8 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 13

Sequence:: Chromosome: 5; NC_003076.8 (25554416..25559499, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation of Arabidopsis UVR8 photoreceptor modulates protein interactions and responses to UV-B radiation.
Title: Phosphorylation of Arabidopsis UVR8 photoreceptor modulates protein interactions and responses to UV-B radiation.
UV RESISTANCE LOCUS 8-Mediated UV-B Response Is Required Alongside CRYPTOCHROME 1 for Plant Survival in Sunlight under Field Conditions.
Title: UV RESISTANCE LOCUS 8-Mediated UV-B Response Is Required Alongside CRYPTOCHROME 1 for Plant Survival in Sunlight under Field Conditions.
RUP2 facilitates UVR8 redimerization via two interfaces.
Title: RUP2 facilitates UVR8 redimerization via two interfaces.
Dynamics and mechanism of dimer dissociation of photoreceptor UVR8.
Title: Dynamics and mechanism of dimer dissociation of photoreceptor UVR8.
Cryptochromes are the dominant photoreceptors mediating heliotropic responses of Arabidopsis inflorescences.
Title: Cryptochromes are the dominant photoreceptors mediating heliotropic responses of Arabidopsis inflorescences.
A novel UV-B priming system reveals an UVR8-depedent memory, which provides resistance against UV-B stress in Arabidopsis leaves.
Title: A novel UV-B priming system reveals an UVR8-depedent memory, which provides resistance against UV-B stress in Arabidopsis leaves.
A constitutively monomeric UVR8 photoreceptor confers enhanced UV-B photomorphogenesis.
Title: A constitutively monomeric UVR8 photoreceptor confers enhanced UV-B photomorphogenesis.
UV RESISTANCE LOCUS8 mediates ultraviolet-B-induced stomatal closure in an ethylene-dependent manner.
Title: UV RESISTANCE LOCUS8 mediates ultraviolet-B-induced stomatal closure in an ethylene-dependent manner.
The photoreceptor UVR8 mediates the perception of both UV-B and UV-A wavelengths up to 350 nm of sunlight with responsivity moderated by cryptochromes.
Title: The photoreceptor UVR8 mediates the perception of both UV-B and UV-A wavelengths up to 350 nm of sunlight with responsivity moderated by cryptochromes.
Coordinated Transcriptional Regulation by the UV-B Photoreceptor and Multiple Transcription Factors for Plant UV-B Responses.
Title: Coordinated Transcriptional Regulation by the UV-B Photoreceptor and Multiple Transcription Factors for Plant UV-B Responses.

Submit: New GeneRIF Correction See all GeneRIFs (55)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_125781.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within entrainment of circadian clock	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to UV	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to UV-B	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to UV-B	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: Regulator of chromosome condensation (RCC1) family protein

NP_201191.1

UVB-RESISTANCE 8 (UVR8); FUNCTIONS IN: chromatin binding, guanyl-nucleotide exchange factor activity; INVOLVED IN: response to UV, response to UV-B; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Regulator of chromosome condensation/beta-lactamase-inhibitor protein II (InterPro:IPR009091), Regulator of chromosome condensation, RCC1 (InterPro:IPR000408); BEST Arabidopsis thaliana protein match is: Regulator of chromosome condensation (RCC1) family with FYVE zinc finger domain (TAIR:AT5G12350.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

25554416..25559499 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125781.4 → NP_201191.1 Regulator of chromosome condensation (RCC1) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_201191.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FN03, Q9XHD7

UniProtKB/TrEMBL

A0A178UGG8, A0A5S9YH09

Conserved Domains (2) summary

COG5184
Location:36 → 363

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

pfam13540
Location:20 → 46

RCC1_2; Regulator of chromosome condensation (RCC1) repeat