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    TERT telomerase reverse transcriptase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831548, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TERT
    Official Full Name
    telomerase reverse transcriptase
    Primary source
    TAIR:AT5G16850
    Locus tag
    AT5G16850
    See related
    Araport:AT5G16850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATTERT; F5E19.190; F5E19_190; telomerase reverse transcriptase
    Summary
    Encodes the catalytic subunit of telomerase reverse transcriptase. Involved in telomere homeostasis. Homozygous double mutants with ATR show gross morphological defects over a period of generations. TERT shows Class II telomerase activity in vitro, indicating that it can initiate de novo telomerase synthesis on non-telomeric DNA, often using a preferred position within the telomerase-bound RNA.
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    Genomic context

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    See TERT in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (5538180..5543657, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene syntaxin of plants 21 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene binding partner of acd11 1 Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Peptidyl-tRNA hydrolase II (PTH2) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A hypomorphic allele of telomerase uncovers the minimal functional length of telomeres in Arabidopsis. Watson JM, et al. Genetics, 2021 Oct 2. PMID 34849882, Free PMC Article
    2. Rearrangements of ribosomal DNA clusters in late generation telomerase-deficient Arabidopsis. Siroky J, et al. Chromosoma, 2003 Oct. PMID 14579127
    3. Role of alternative telomere lengthening unmasked in telomerase knock-out mutant plants. Růcková E, et al. Plant Mol Biol, 2008 Apr. PMID 18239859
    4. Molecular analysis of T-DNA insertion mutants identified putative regulatory elements in the AtTERT gene. Fojtová M, et al. J Exp Bot, 2011 Nov. PMID 21865176, Free PMC Article
    5. Telomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase. Schrumpfová PP, et al. Plant J, 2014 Mar. PMID 24397874, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A hypomorphic allele of telomerase uncovers the minimal functional length of telomeres in Arabidopsis.
      Title: A hypomorphic allele of telomerase uncovers the minimal functional length of telomeres in Arabidopsis.
    2. Origin and Fates of TERT Gene Copies in Polyploid Plants.
      Title: Origin and Fates of TERT Gene Copies in Polyploid Plants.
    3. Telomere shortening is more rapid in fas tert double mutants than in fas1, fas2 or tert single mutant plants.
      Title: A telomerase-independent component of telomere loss in chromatin assembly factor 1 mutants of Arabidopsis thaliana.
    4. Silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.
      Title: Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.
    5. Attert (-/-) mutant plants were propagated from seeds coming either from the lower-most or the upper-most siliques (L- and U-plants) and the length of their telomeres were followed over several generations.
      Title: Role of alternative telomere lengthening unmasked in telomerase knock-out mutant plants.
    6. AtTERT, the telomerase catalytic subunit, accumulates in the plant nucleolus, and AtNAP57 associates with active telomerase RNP particles in an RNA-dependent manner.
      Title: Dyskerin is a component of the Arabidopsis telomerase RNP required for telomere maintenance.
    7. study reports the physical interaction of an Arabidopsis POT1 protein, POT1A (At5g05210), with an N-terminal peptide of the catalytic subunit of the telomerase TERT encoded by a 5' mRNA splicing variant
      Title: Arabidopsis POT1A interacts with TERT-V(I8), an N-terminal splicing variant of telomerase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001343468.1
    NM_121691.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables telomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables telomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromosome localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chromosome organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within meristem maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root meristem growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in telomere maintenance via telomerase IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    telomerase reverse transcriptase
    NP_197187.1
    • telomerase reverse transcriptase (TERT); FUNCTIONS IN: telomerase activity, telomeric template RNA reverse transcriptase activity; INVOLVED IN: nucleolus organization, telomere maintenance via telomerase, chromosome organization, chromosome localization; LOCATED IN: nucleus; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Telomere reverse transcriptase (InterPro:IPR003545), RNA-directed DNA polymerase (reverse transcriptase) (InterPro:IPR000477), Telomerase ribonucleoprotein complex - RNA-binding domain (InterPro:IPR021891); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5538180..5543657 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121691.4 → NP_197187.1  telomerase reverse transcriptase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197187.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SE99, Q9SPU7
      UniProtKB/TrEMBL
      A0A178UJE7, A0A5S9Y4S7
      Conserved Domains (2) summary
      smart00975
      Location:452 → 592
      Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
      cd01648
      Location:795 → 930
      TERT; Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as telomerase ...

    2. NM_001343468.1 → NP_001330126.1  telomerase reverse transcriptase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B9U1, A0A5S9Y4S7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SPU7.1

    Gene LinkOut

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