SYP21 syntaxin of plants 21 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SYP21
Official Full Name: syntaxin of plants 21
Primary source: TAIR:AT5G16830
Locus tag: AT5G16830
See related: Araport:AT5G16830
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATPEP12; ATSYP21; PEP12; PEP12P; syntaxin of plants 21; syntaxin of plants 21
Summary: member of SYP2 Gene Family. Over-expression of the gene in tobacco protoplasts leads to a disruption of vacuolar transport from the prevacuolar compartment (PVC) to the vacuole, but not from the Golgi apparatus to the plasma membrane.
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Genomic context

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See SYP21 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 7

Sequence:: Chromosome: 5; NC_003076.8 (5532846..5535295, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SYP21, SYP22 and SYP23 function redundantly in vacuolar protein transport, vein patterning, myrosin cell differentiation and plant growth.
Title: Arabidopsis Qa-SNARE SYP2 proteins localized to different subcellular regions function redundantly in vacuolar protein sorting and plant development.
The functions of VAM3/SYP22 and PEP12/SYP21 are redundant and interchangeable.
Title: Vacuolar/pre-vacuolar compartment Qa-SNAREs VAM3/SYP22 and PEP12/SYP21 have interchangeable functions in Arabidopsis.
PEP12/SYP21 is involved in vacuolar sorting and excess of this syntaxin in the prevacuolar complex can be detrimental for further transport from this organelle.
Title: Overexpression of the Arabidopsis syntaxin PEP12/SYP21 inhibits transport from the prevacuolar compartment to the lytic vacuole in vivo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_121689.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables SNAP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables SNAP receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables SNAP receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi to vacuole transport	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within intracellular protein transport	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within late endosome to vacuole transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within membrane fusion	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within protein targeting to vacuole	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISM Inferred from Sequence Model more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	TAS Traceable Author Statement more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network transport vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network transport vesicle	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: syntaxin of plants 21

NP_197185.1

syntaxin of plants 21 (SYP21); CONTAINS InterPro DOMAIN/s: Target SNARE coiled-coil domain (InterPro:IPR000727), Syntaxin/epimorphin, conserved site (InterPro:IPR006012), t-SNARE (InterPro:IPR010989), Syntaxin, N-terminal (InterPro:IPR006011); BEST Arabidopsis thaliana protein match is: Syntaxin/t-SNARE family protein (TAIR:AT5G46860.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

5532846..5535295 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_121689.4 → NP_197185.1 syntaxin of plants 21 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_197185.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q39233

UniProtKB/TrEMBL

A0A178UQL2, A0A384LDU7, Q1WW70

Conserved Domains (2) summary

cd00179
Location:27 → 164

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

cd15840
Location:189 → 247

SNARE_Qa; SNARE motif, subgroup Qa