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    FH3 formin 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827184, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FH3
    Official Full Name
    formin 3
    Primary source
    TAIR:AT4G15200
    Locus tag
    AT4G15200
    See related
    Araport:AT4G15200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AFH3; DL3645C; FCAALL.218; formin 3
    Summary
    Actin nucleation factor that directs the formation of actin cables in pollen tubes. Involved in cytoplasmic streaming and polarized growth in pollen tubes.
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    Genomic context

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    See FH3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Sequence:
    Chromosome: 4; NC_003075.7 (8662824..8666050, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein Neighboring gene SET domain protein 2 Neighboring gene beta-amylase 5 Neighboring gene pleiotropic drug resistance 13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis formin3 directs the formation of actin cables and polarized growth in pollen tubes. Ye J, et al. Plant Cell, 2009 Dec. PMID 20023198, Free PMC Article
    2. Arabidopsis class I formins control membrane-originated actin polymerization at pollen tube tips. Lan Y, et al. PLoS Genet, 2018 Nov. PMID 30418966, Free PMC Article
    3. Formin homology 2 domains occur in multiple contexts in angiosperms. Cvrcková F, et al. BMC Genomics, 2004 Jul 15. PMID 15256004, Free PMC Article
    4. Formins: intermediates in signal-transduction cascades that affect cytoskeletal reorganization. Deeks MJ, et al. Trends Plant Sci, 2002 Nov. PMID 12417149
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_117608.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within actin nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cytoplasmic streaming IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in intracellular anatomical structure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    formin 3
    NP_001190736.2
    • formin 3 (FH3); CONTAINS InterPro DOMAIN/s: Actin-binding FH2/DRF autoregulatory (InterPro:IPR003104), Actin-binding FH2 (InterPro:IPR015425); BEST Arabidopsis thaliana protein match is: formin homology5 (TAIR:AT5G54650.2).
    NP_193255.6
    • formin 3 (FH3); CONTAINS InterPro DOMAIN/s: Actin-binding FH2/DRF autoregulatory (InterPro:IPR003104), Actin-binding FH2 (InterPro:IPR015425); BEST Arabidopsis thaliana protein match is: formin homology5 (TAIR:AT5G54650.2); Has 4532 Blast hits to 3854 proteins in 397 species: Archae - 0; Bacteria - 318; Metazoa - 1880; Fungi - 396; Plants - 835; Viruses - 88; Other Eukaryotes - 1015 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      8662824..8666050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203807.2 → NP_001190736.2  formin 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JJE8

    2. NM_001340996.1 → NP_001328296.1  formin 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B463

    3. NM_001340997.1 → NP_001328295.1  formin 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B462

    4. NM_117608.5 → NP_193255.6  formin 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JNE0
    Nucleotide Protein
    Heading Accession and Version

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