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    CRR4 Pentatricopeptide repeat (PPR) superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819143, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CRR4
    Official Full Name
    Pentatricopeptide repeat (PPR) superfamily protein
    Primary source
    TAIR:AT2G45350
    Locus tag
    AT2G45350
    See related
    Araport:AT2G45350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CHLORORESPIRATORY REDUCTION 4; F4L23.14
    Summary
    Encodes a member of a PCMP (plant combinatorial and modular protein) family (PCMP-E subfamily) with 11 pentatricopeptide (PPR) repeats. The protein is involved in RNA editing of the initiation codon of ndhD in the chloroplast.
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    Genomic context

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    See CRR4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (18694816..18696691, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene polyphosphatidylinositol phosphatase Neighboring gene RNA 2'-phosphotransferase, Tpt1 / KptA family Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene ankyrin repeat/KH domain protein (DUF1442) Neighboring gene ncRNA Neighboring gene myeloid leukemia factor Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A pentatricopeptide repeat protein is a site recognition factor in chloroplast RNA editing. Okuda K, et al. J Biol Chem, 2006 Dec 8. PMID 17015439
    2. A pentatricopeptide repeat protein is essential for RNA editing in chloroplasts. Kotera E, et al. Nature, 2005 Jan 20. PMID 15662426
    3. Two interacting proteins are necessary for the editing of the NdhD-1 site in Arabidopsis plastids. Boussardon C, et al. Plant Cell, 2012 Sep. PMID 23001034, Free PMC Article
    4. Large-scale characterization of integral proteins from Arabidopsis vacuolar membrane by two-dimensional liquid chromatography. Szponarski W, et al. Proteomics, 2004 Feb. PMID 14760709
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DYW1, by interaction with CRR4, provides in trans an essential function required for editing of the ndhD-1 site.
      Title: Two interacting proteins are necessary for the editing of the NdhD-1 site in Arabidopsis plastids.
    2. the pentatricopeptide repeat protein CRR4 is a sequence-specific RNA-binding protein that acts as a site recognition factor in plastid RNA editing
      Title: A pentatricopeptide repeat protein is a site recognition factor in chloroplast RNA editing.
    3. crr4 is among genes responsible for the specific RNA editing event in the chloroplast [CRR4]
      Title: A pentatricopeptide repeat protein is essential for RNA editing in chloroplasts.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_130098.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chloroplast RNA modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    Pentatricopeptide repeat (PPR) superfamily protein
    NP_182060.2
    • CHLORORESPIRATORY REDUCTION 4 (CRR4); INVOLVED IN: mRNA modification; LOCATED IN: chloroplast, vacuole; CONTAINS InterPro DOMAIN/s: Pentatricopeptide repeat (InterPro:IPR002885); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT4G02750.1); Has 36388 Blast hits to 13274 proteins in 208 species: Archae - 0; Bacteria - 3; Metazoa - 67; Fungi - 16; Plants - 35908; Viruses - 0; Other Eukaryotes - 394 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18694816..18696691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130098.3 → NP_182060.2  Pentatricopeptide repeat (PPR) superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182060.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22137
      UniProtKB/TrEMBL
      A0A178W0U9
      Conserved Domains (4) summary
      sd00004
      Location:254 → 281
      PPR; PPR repeat [structural motif]
      pfam01535
      Location:253 → 283
      PPR; PPR repeat
      pfam12854
      Location:280 → 310
      PPR_1; PPR repeat
      pfam13041
      Location:250 → 295
      PPR_2; PPR repeat family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22137.2

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