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    KIF2C kinesin family member 2C [ Homo sapiens (human) ]

    Gene ID: 11004, updated on 27-Nov-2024

    Summary

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    Official Symbol
    KIF2Cprovided by HGNC
    Official Full Name
    kinesin family member 2Cprovided by HGNC
    Primary source
    HGNC:HGNC:6393
    See related
    Ensembl:ENSG00000142945 MIM:604538; AllianceGenome:HGNC:6393
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCAK; CT139; KNSL6
    Summary
    This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Expression
    Biased expression in testis (RPKM 39.1), bone marrow (RPKM 9.5) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KIF2C in Genome Data Viewer
    Location:
    1p34.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (44739837..44767767)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (44610697..44638762)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45205509..45233439)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene armadillo like helical domain containing 1 Neighboring gene uncharacterized LOC105378690 Neighboring gene Sharpr-MPRA regulatory region 12667 Neighboring gene RNA, U5F small nuclear 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 816 Neighboring gene Sharpr-MPRA regulatory region 12642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:45200330-45200889 Neighboring gene RNA, U5D small nuclear 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 944 Neighboring gene small nucleolar RNA, C/D box 160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 817 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 945 Neighboring gene small nucleolar RNA, C/D box 55 Neighboring gene small nucleolar RNA, C/D box 46 Neighboring gene ribosomal protein S8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. New Insights into the Coupling between Microtubule Depolymerization and ATP Hydrolysis by Kinesin-13 Protein Kif2C. Wang W, et al. J Biol Chem, 2015 Jul 24. PMID 26055718, Free PMC Article
    2. Overexpression of mitotic centromere-associated Kinesin stimulates microtubule detachment and confers resistance to paclitaxel. Ganguly A, et al. Mol Cancer Ther, 2011 Jun. PMID 21471284, Free PMC Article
    3. The bidirectional depolymerizer MCAK generates force by disassembling both microtubule ends. Oguchi Y, et al. Nat Cell Biol, 2011 May 22. PMID 21602793
    4. Depolymerizing kinesins Kip3 and MCAK shape cellular microtubule architecture by differential control of catastrophe. Gardner MK, et al. Cell, 2011 Nov 23. PMID 22118464
    5. Mitosis phase enrichment with identification of mitotic centromere-associated kinesin as a therapeutic target in castration-resistant prostate cancer. Sircar K, et al. PLoS One, 2012. PMID 22363599, Free PMC Article

    See all (197) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kinesin family member 2C promotes hepatocellular carcinoma growth and metastasis via activating MEK/ERK pathway.
      Title: Kinesin family member 2C promotes hepatocellular carcinoma growth and metastasis via activating MEK/ERK pathway.
    2. Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction.
      Title: Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction.
    3. KIF2C promotes clear cell renal cell carcinoma progression via activating JAK2/STAT3 signaling pathway.
      Title: KIF2C promotes clear cell renal cell carcinoma progression via activating JAK2/STAT3 signaling pathway.
    4. Knockdown of kinesin family member 2C restricts cell proliferation and induces cell cycle arrest in gastric cancer.
      Title: Knockdown of kinesin family member 2C restricts cell proliferation and induces cell cycle arrest in gastric cancer.
    5. Comprehensive analysis of the effects of KIF2C on prognosis, biological functions and immune infiltration in PAAD.
      Title: Comprehensive analysis of the effects of KIF2C on prognosis, biological functions and immune infiltration in PAAD.
    6. KIF2C affects sperm cell differentiation in patients with Klinefelter syndrome, as revealed by RNA-Seq and scRNA-Seq data.
      Title: KIF2C affects sperm cell differentiation in patients with Klinefelter syndrome, as revealed by RNA-Seq and scRNA-Seq data.
    7. Large-Scale Transcriptome Data Analysis Identifies KIF2C as a Potential Therapeutic Target Associated With Immune Infiltration in Prostate Cancer.
      Title: Large-Scale Transcriptome Data Analysis Identifies KIF2C as a Potential Therapeutic Target Associated With Immune Infiltration in Prostate Cancer.
    8. Activation of the TGF-beta1/Smad signaling by KIF2C contributes to the malignant phenotype of thyroid carcinoma cells.
      Title: Activation of the TGF-β1/Smad signaling by KIF2C contributes to the malignant phenotype of thyroid carcinoma cells.
    9. Atomic force microscopy reveals distinct protofilament-scale structural dynamics in depolymerizing microtubule arrays.
      Title: Atomic force microscopy reveals distinct protofilament-scale structural dynamics in depolymerizing microtubule arrays.
    10. KIF2C: a novel link between Wnt/beta-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma.
      Title: KIF2C: a novel link between Wnt/β-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (73)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The DNA repair gene DNA-PKcs and cell cycle-related genes Cdc20, Cdc25C, KIF2C and CTS1 are downregulated in HIV-1 Tat-expressing human rhabdomyosarcoma cells PubMed
    Vpr vpr HIV-1 Vpr upregulates KIF2C in HeLa cells within 12 hours of exposure PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables centromeric DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment or maintenance of microtubule cytoskeleton polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule depolymerization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in postsynaptic cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with cytoplasmic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    located_in microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule plus-end TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF2C
    Names
    kinesin-like protein 6
    mitotic centromere-associated kinesin
    testis tissue sperm-binding protein Li 68n

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297655.2 → NP_001284584.1  kinesin-like protein KIF2C isoform 2

      See identical proteins and their annotated locations for NP_001284584.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB264115, AK300756, BU615368
      UniProtKB/TrEMBL
      A8K3S3, B7Z6Q6
      Conserved Domains (2) summary
      cd01367
      Location:217 → 545
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:223 → 546
      Kinesin; Kinesin motor domain

    2. NM_001297656.2 → NP_001284585.1  kinesin-like protein KIF2C isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as tsMCAK) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK302267, AY026505, BC014924, BU615368, DC404550
      Consensus CDS
      CCDS72774.1
      UniProtKB/TrEMBL
      A8K3S3
      Related
      ENSP00000361291.1, ENST00000372217.5
      Conserved Domains (2) summary
      cd01367
      Location:204 → 532
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:210 → 533
      Kinesin; Kinesin motor domain

    3. NM_001297657.2 → NP_001284586.1  kinesin-like protein KIF2C isoform 4

      See identical proteins and their annotated locations for NP_001284586.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK302267, BC014924, BU615368, DC399082
      UniProtKB/TrEMBL
      A8K3S3, B7Z7M6, E9PDS6
      Conserved Domains (2) summary
      cd01367
      Location:145 → 473
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:151 → 474
      Kinesin; Kinesin motor domain

    4. NM_006845.4 → NP_006836.2  kinesin-like protein KIF2C isoform 1

      See identical proteins and their annotated locations for NP_006836.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AU130795, BC008764, BC014924, BU615368
      Consensus CDS
      CCDS512.1
      UniProtKB/Swiss-Prot
      B3ITR9, Q5JR88, Q6ICU1, Q96C18, Q96HB8, Q99661, Q9BWV8
      UniProtKB/TrEMBL
      A0A140VKF1, A8K3S3
      Related
      ENSP00000361298.4, ENST00000372224.9
      Conserved Domains (1) summary
      cd01367
      Location:258 → 586
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      44739837..44767767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441702.1 → XP_047297658.1  kinesin-like protein KIF2C isoform X1

    2. XM_047441708.1 → XP_047297664.1  kinesin-like protein KIF2C isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      44610697..44638762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333958.1 → XP_054189933.1  kinesin-like protein KIF2C isoform X2

    2. XM_054333957.1 → XP_054189932.1  kinesin-like protein KIF2C isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99661.2 GenPept UniProtKB/Swiss-Prot:Q99661

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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