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    PEX10 peroxin 10 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817175, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PEX10
    Official Full Name
    peroxin 10
    Primary source
    TAIR:AT2G26350
    Locus tag
    AT2G26350
    See related
    Araport:AT2G26350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPEX10; peroxin 10; T9J22.2
    Summary
    Zinc-binding peroxisomal integral membrane protein (PEX10). Inserted directly from the cytosol into peroxisomes and is involved in importing proteins into the peroxisome. Required for embryogenesis.
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    Genomic context

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    See PEX10 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Sequence:
    Chromosome: 2; NC_003071.7 (11217142..11220541, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Leucine-rich receptor-like protein kinase family protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Mitochondrial substrate carrier family protein Neighboring gene MD-2-related lipid recognition domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of peroxisome biogenesis factor 10 reduces cuticular wax accumulation by disrupting the ER network in Arabidopsis thaliana. Kamigaki A, et al. Plant Cell Physiol, 2009 Dec. PMID 19892830
    2. Requirement of the C3HC4 zinc RING finger of the Arabidopsis PEX10 for photorespiration and leaf peroxisome contact with chloroplasts. Schumann U, et al. Proc Natl Acad Sci U S A, 2007 Jan 16. PMID 17215364, Free PMC Article
    3. An Arabidopsis pex10 null mutant is embryo lethal, implicating peroxisomes in an essential role during plant embryogenesis. Sparkes IA, et al. Plant Physiol, 2003 Dec. PMID 14576288, Free PMC Article
    4. AthPEX10, a nuclear gene essential for peroxisome and storage organelle formation during Arabidopsis embryogenesis. Schumann U, et al. Proc Natl Acad Sci U S A, 2003 Aug 5. PMID 12883010, Free PMC Article
    5. AtPEX2 and AtPEX10 are targeted to peroxisomes independently of known endoplasmic reticulum trafficking routes. Sparkes IA, et al. Plant Physiol, 2005 Oct. PMID 16169966, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PEX2 and PEX10 cooperate to support import of matrix proteins into plant peroxisomes and peroxin5 retrotranslocation in Arabidopsis.
      Title: Peroxisomal ubiquitin-protein ligases peroxin2 and peroxin10 have distinct but synergistic roles in matrix protein import and peroxin5 retrotranslocation in Arabidopsis.
    2. Data show that formation of glyoxysomal reticulum seemed to be impaired in PEX10-DeltaZn but not in PEX2-DeltaZn-T7 or PEX12-DeltaZn-T7 plants.
      Title: Different functions of the C3HC4 zinc RING finger peroxins PEX10, PEX2, and PEX12 in peroxisome formation and matrix protein import.
    3. Cuticular wax formation in AtPEX10i is inhibited by down-regulation of the genes involved in wax biosynthesis and mislocalization of the gene products by disrupting the endoplasmic reticulum network.
      Title: Suppression of peroxisome biogenesis factor 10 reduces cuticular wax accumulation by disrupting the ER network in Arabidopsis thaliana.
    4. AtPEX19-1 was shown to bind to the Arabidopsis peroxisomal membrane protein PEX10.
      Title: Arabidopsis PEX19 is a dimeric protein that binds the peroxin PEX10.
    5. PEX2 and PEX10 are inserted into peroxisome membranes directly from the cytosol.
      Title: AtPEX2 and AtPEX10 are targeted to peroxisomes independently of known endoplasmic reticulum trafficking routes.
    6. inactivation of the RING finger domain in PEX10 has eliminated protein interaction required for attachment of peroxisomes to chloroplasts and movement of metabolites between peroxisomes and chloroplasts
      Title: Requirement of the C3HC4 zinc RING finger of the Arabidopsis PEX10 for photorespiration and leaf peroxisome contact with chloroplasts.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001336062.1
    NM_128192.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within peroxisome-chloroplast membrane tethering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photorespiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein import into peroxisome matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxin 10
    NP_565621.1
    • peroxin 10 (PEX10); FUNCTIONS IN: zinc ion binding; INVOLVED IN: in 6 processes; LOCATED IN: cytosol, peroxisome; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841), Pex, N-terminal (InterPro:IPR006845), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING membrane-anchor 1 (TAIR:AT4G03510.2); Has 4616 Blast hits to 4603 proteins in 297 species: Archae - 0; Bacteria - 0; Metazoa - 2406; Fungi - 531; Plants - 966; Viruses - 101; Other Eukaryotes - 612 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11217142..11220541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336059.1 → NP_001323820.1  peroxin 10 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VV19, A0A1P8AYA6, A0A384L7H9

    2. NM_001336060.1 → NP_001323819.1  peroxin 10 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AYB2

    3. NM_001336061.1 → NP_001323818.1  peroxin 10 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VV19, A0A1P8AYA6, A0A384L7H9

    4. NM_128192.2 → NP_565621.1  peroxin 10 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565621.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65895, Q8LBN2, Q8S8Q5, Q9M400, Q9SYU4
      UniProtKB/TrEMBL
      A0A178VWJ2, A0A7G2ECK6
      Conserved Domains (3) summary
      COG5574
      Location:292 → 376
      PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd16527
      Location:326 → 365
      RING-HC_PEX10; RING finger, HC subclass, found in peroxin-10 (PEX10) and similar proteins
      pfam04757
      Location:41 → 273
      Pex2_Pex12; Pex2 / Pex12 amino terminal region

    5. NM_001336062.1 → NP_001323817.1  peroxin 10 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AY59
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SYU4.1

    Gene LinkOut

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