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    MMZ3 MMS ZWEI homologue 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818179, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MMZ3
    Official Full Name
    MMS ZWEI homologue 3
    Primary source
    TAIR:AT2G36060
    Locus tag
    AT2G36060
    See related
    Araport:AT2G36060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F11F19.3; F11F19_3; MMS ZWEI homologue 3; UBIQUITIN E2 VARIANT 1C; UEV1C
    Summary
    MMZ3/UEV1C encodes a protein that may play a role in DNA damage responses and error-free post-replicative DNA repair by participating in lysine-63-based polyubiquitination reactions. UEV1C can form diubiquitin and triubiquitin chains in combination with UBC13A/UBC35 in vitro. It can also functionally complement an mms2 mutation in budding yeast, both by increasing mms2 mutant viability in the presence of the DNA damaging agent MMS, and by reducing the rate of spontaneous DNA mutation. It can also rescue an mms2 ubc13 double mutant in yeast in combination with UBC13A. MMZ3/UEV1C transcripts are found at moderate levels in most plant organs, but cannot be detected in the pollen or 2 days after germination. Transcript levels do not appear to be stress-inducible.
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    Genomic context

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    See MMZ3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (15142653..15144221, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ovate family protein 15 Neighboring gene translocase inner membrane subunit 44-2 Neighboring gene AP2/B3-like transcriptional factor family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis UEV1D promotes Lysine-63-linked polyubiquitination and is involved in DNA damage response. Wen R, et al. Plant Cell, 2008 Jan. PMID 18178771, Free PMC Article
    2. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    3. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    NM_001084542.1
    NM_129165.4
    NM_179928.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within postreplication repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of UBC13-MMS2 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MMS ZWEI homologue 3
    NP_001078011.1
    • MMS ZWEI homologue 3 (MMZ3); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin E2 variant 1D-4 (TAIR:AT3G52560.1); Has 2913 Blast hits to 2913 proteins in 284 species: Archae - 0; Bacteria - 0; Metazoa - 1555; Fungi - 342; Plants - 599; Viruses - 0; Other Eukaryotes - 417 (source: NCBI BLink).
    NP_565834.1
    • MMS ZWEI homologue 3 (MMZ3); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin E2 variant 1D-4 (TAIR:AT3G52560.1); Has 2912 Blast hits to 2912 proteins in 287 species: Archae - 0; Bacteria - 0; Metazoa - 1566; Fungi - 354; Plants - 579; Viruses - 0; Other Eukaryotes - 413 (source: NCBI BLink).
    NP_850259.1
    • MMS ZWEI homologue 3 (MMZ3); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin E2 variant 1D-4 (TAIR:AT3G52560.2); Has 1347 Blast hits to 1347 proteins in 246 species: Archae - 0; Bacteria - 0; Metazoa - 655; Fungi - 163; Plants - 359; Viruses - 0; Other Eukaryotes - 170 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      15142653..15144221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129165.4 → NP_565834.1  MMS ZWEI homologue 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565834.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MQX2, Q3EBM3, Q9SJ44
      UniProtKB/TrEMBL
      A0A178VPH8, A0A5S9X4C4, A0A7G2EFT3
      Conserved Domains (1) summary
      smart00212
      Location:16 → 142
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    2. NM_001084542.1 → NP_001078011.1  MMS ZWEI homologue 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078011.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EFT3
      Conserved Domains (1) summary
      smart00212
      Location:16 → 141
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    3. NM_179928.2 → NP_850259.1  MMS ZWEI homologue 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850259.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VRN9, A0A7G2EFT3
      Conserved Domains (1) summary
      smart00212
      Location:16 → 143
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SJ44.1

    Gene LinkOut

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