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    TANGO6 transport and golgi organization 6 homolog [ Homo sapiens (human) ]

    Gene ID: 79613, updated on 27-Nov-2024

    Summary

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    Official Symbol
    TANGO6provided by HGNC
    Official Full Name
    transport and golgi organization 6 homologprovided by HGNC
    Primary source
    HGNC:HGNC:25749
    See related
    Ensembl:ENSG00000103047 MIM:620188; AllianceGenome:HGNC:25749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TMCO7
    Summary
    Predicted to be involved in protein secretion. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 3.5), liver (RPKM 3.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TANGO6 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (68843531..69085182)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (74639794..74881499)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68877434..69119085)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68778919-68779504 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68780069 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68787439-68788396 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68790502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11025 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68791231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11026 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68792712 Neighboring gene RNA, 5S ribosomal pseudogene 429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11029 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68799944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68800316-68800990 Neighboring gene melanoma risk locus-associated MPRA allelic enhancers 16:68802068 and 16:68802072 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68803726 Neighboring gene Sharpr-MPRA regulatory region 4224 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68808283 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68813037-68813640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68813641-68814242 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68814316 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68815000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11031 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68818245 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68818709 Neighboring gene cadherin 1 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68820718 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68825333-68825902 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:68826109 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:68827591-68828091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68829108-68829608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68829609-68830109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11033 Neighboring gene ferritin light chain pseudogene 14 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:68900664-68900823 Neighboring gene MPRA-validated peak2625 silencer Neighboring gene RNA, U7 small nuclear 42 pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:69006410-69006910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:69011625-69012125 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:69022345-69022846 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:69022847-69023346 Neighboring gene RNA, U6 small nuclear 898, pseudogene Neighboring gene deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11034 Neighboring gene ribosomal protein S2 pseudogene 45 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:69096798-69097616 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:69105561-69106280 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:69106281-69106998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69106999-69107717 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69107718-69108435 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69111819-69112338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69122977-69123854 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69131715-69132540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:69133965-69134466 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:69139221-69139769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7651 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69143266-69144235 Neighboring gene hyaluronan synthase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7652 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7653 Neighboring gene chromosome transmission fidelity factor 8 Neighboring gene DERPC proline and glycine rich nuclear protein Neighboring gene UTP4 small subunit processome component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes. Martínez-Noël G, et al. J Mol Biol, 2018 Mar 30. PMID 29426014, Free PMC Article
    2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Dec 31. PMID 11214970
    3. Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. Nakayama M, et al. Genome Res, 2002 Nov. PMID 12421765, Free PMC Article
    4. BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion. Chan CJ, et al. Mol Cell Proteomics, 2019 Nov. PMID 31519766, Free PMC Article
    5. R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein. Cloutier P, et al. Nat Commun, 2017 May 31. PMID 28561026, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12688, KIAA1746

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transport and Golgi organization protein 6 homolog
    Names
    transmembrane and coiled-coil domain-containing protein 7
    transmembrane and coiled-coil domains 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024562.2 → NP_078838.1  transport and Golgi organization protein 6 homolog

      See identical proteins and their annotated locations for NP_078838.1

      Status: VALIDATED

      Source sequence(s)
      AB051533, AC009082, AK095333, BQ005531
      Consensus CDS
      CCDS45516.1
      UniProtKB/Swiss-Prot
      Q569F9, Q9C0B7, Q9H9K1
      UniProtKB/TrEMBL
      B3KTB6
      Related
      ENSP00000261778.1, ENST00000261778.2
      Conserved Domains (3) summary
      sd00044
      Location:838 → 867
      HEAT; HEAT repeat [structural motif]
      pfam10304
      Location:1041 → 1073
      RTP1_C2; Required for nuclear transport of RNA pol II C-terminus 2
      pfam10363
      Location:842 → 949
      RTP1_C1; Required for nuclear transport of RNA pol II C-terminus 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      68843531..69085182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434632.1 → XP_047290588.1  transport and Golgi organization protein 6 homolog isoform X1

    2. XM_011523327.4 → XP_011521629.1  transport and Golgi organization protein 6 homolog isoform X2

      Conserved Domains (1) summary
      pfam10363
      Location:841 → 901
      RTP1_C1; Required for nuclear transport of RNA pol II C-terminus 1

    3. XM_047434633.1 → XP_047290589.1  transport and Golgi organization protein 6 homolog isoform X3

    4. XM_047434634.1 → XP_047290590.1  transport and Golgi organization protein 6 homolog isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      74639794..74881499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313925.1 → XP_054169900.1  transport and Golgi organization protein 6 homolog isoform X1

    2. XM_054313926.1 → XP_054169901.1  transport and Golgi organization protein 6 homolog isoform X2

    3. XM_054313927.1 → XP_054169902.1  transport and Golgi organization protein 6 homolog isoform X3

    4. XM_054313928.1 → XP_054169903.1  transport and Golgi organization protein 6 homolog isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C0B7.2 GenPept UniProtKB/Swiss-Prot:Q9C0B7

    Gene LinkOut

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