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    AGO3 ARGONAUTE 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840017, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AGO3
    Official Full Name
    ARGONAUTE 3
    Primary source
    TAIR:AT1G31290
    Locus tag
    AT1G31290
    See related
    Araport:AT1G31290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARGONAUTE 3; T19E23.8; T19E23_8
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    Genomic context

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    See AGO3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (11188120..11192585)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene Argonaute family protein Neighboring gene TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of Arabidopsis ARGONAUTE 3 in reproductive tissues. Jullien PE, et al. Plant J, 2020 Aug. PMID 32506562
    2. Arabidopsis AGO3 predominantly recruits 24-nt small RNAs to regulate epigenetic silencing. Zhang Z, et al. Nat Plants, 2016 Apr 18. PMID 27243648
    3. Abscisic Acid Induces Resistance against Bamboo Mosaic Virus through Argonaute2 and 3. Alazem M, et al. Plant Physiol, 2017 May. PMID 28270624, Free PMC Article
    4. Antiviral ARGONAUTEs Against Turnip Crinkle Virus Revealed by Image-Based Trait Analysis. Zheng X, et al. Plant Physiol, 2019 Jul. PMID 31043494, Free PMC Article
    5. Functional and Genetic Analysis Identify a Role for Arabidopsis ARGONAUTE5 in Antiviral RNA Silencing. Brosseau C, et al. Plant Cell, 2015 Jun. PMID 26023161, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional characterization of Arabidopsis ARGONAUTE 3 in reproductive tissues.
      Title: Functional characterization of Arabidopsis ARGONAUTE 3 in reproductive tissues.
    2. Antiviral ARGONAUTEs Against Turnip Crinkle Virus Revealed by Image-Based Trait Analysis.
      Title: Antiviral ARGONAUTEs Against Turnip Crinkle Virus Revealed by Image-Based Trait Analysis.
    3. Data show that Argonaute family protein AGO2 and AGO3 were important for abscisic acid (ABA)-mediated resistance.
      Title: Abscisic Acid Induces Resistance against Bamboo Mosaic Virus through Argonaute2 and 3.
    4. AGO3 could not complement the signature function of AGO2, the closest genetic paralog of AGO3, in host antiviral defence. It was also found, surprisingly, that AGO3 predominantly bound 24-nt sRNAs with 5'-terminal adenine. The spectrum of AGO3-associated sRNAs was different from those bound to AGO2, further indicating their functional divergence.
      Title: Arabidopsis AGO3 predominantly recruits 24-nt small RNAs to regulate epigenetic silencing.
    Submit: New GeneRIF Correction

    General gene information

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    NM_102867.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ARGONAUTE 3
    NP_174414.1
    • ARGONAUTE 3 (AGO3); FUNCTIONS IN: nucleic acid binding; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: LP.06 six leaves visible, LP.04 four leaves visible, 4 anthesis, C globular stage, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Domain of unknown function DUF1785 (InterPro:IPR014811), Stem cell self-renewal protein Piwi (InterPro:IPR003165), Argonaute/Dicer protein, PAZ (InterPro:IPR003100), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337); BEST Arabidopsis thaliana protein match is: Argonaute family protein (TAIR:AT1G31280.1); Has 87664 Blast hits to 32385 proteins in 1910 species: Archae - 110; Bacteria - 26465; Metazoa - 27622; Fungi - 6311; Plants - 10699; Viruses - 1201; Other Eukaryotes - 15256 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      11188120..11192585
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001332952.1 → NP_001322307.1  ARGONAUTE 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ATL0, A0A5S9WGV1

    2. NM_001332953.1 → NP_001322306.1  ARGONAUTE 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WI29, A0A1P8ATK9

    3. NM_102867.2 → NP_174414.1  ARGONAUTE 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174414.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SHF2
      UniProtKB/TrEMBL
      A0A5S9WGV1
      Conserved Domains (4) summary
      PLN03202
      Location:318 → 1138
      PLN03202; protein argonaute; Provisional
      cd04657
      Location:703 → 1144
      Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
      pfam02170
      Location:560 → 663
      PAZ; PAZ domain
      pfam16486
      Location:336 → 479
      ArgoN; N-terminal domain of argonaute
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SHF2.1

    Gene LinkOut

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