RBOH F respiratory burst oxidase protein F [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RBOH F
Official Full Name: respiratory burst oxidase protein F
Primary source: TAIR:AT1G64060
Locus tag: AT1G64060
See related: Araport:AT1G64060
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA RESPIRATORY BURST OXIDASE HOMOLOG F; ARABIDOPSIS THALIANA RESPIRATORY BURST OXIDASE HOMOLOG F; ATRBOH F; ATRBOHF; CYTOCHROME B245 BETA CHAIN HOMOLOG RBOHAP108; F22C12.18; F22C12_18; RBOHAP108; RBOHF; respiratory burst oxidase protein F; RESPIRATORY BURST OXIDASE PROTEIN F
Summary: Interacts with AtrbohD gene to fine tune the spatial control of ROI production and hypersensitive response to cell in and around infection site.
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Genomic context

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See RBOH F in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 14

Sequence:: Chromosome: 1; NC_003070.9 (23769774..23776984)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RBOHF activates stomatal immunity by modulating both reactive oxygen species and apoplastic pH dynamics in Arabidopsis.
Title: RBOHF activates stomatal immunity by modulating both reactive oxygen species and apoplastic pH dynamics in Arabidopsis.
NADPH Oxidase-derived ROS promote mitochondrial alkalization under salt stress in Arabidopsis root cells.
Title: NADPH Oxidase-derived ROS promote mitochondrial alkalization under salt stress in Arabidopsis root cells.
These findings identify RBOHF as a convergence point targeted by a complex regulatory network of kinases and phosphatases.
Title: Fine-tuning of RBOHF activity is achieved by differential phosphorylation and Ca(2+) binding.
RBOHF role in the stomatal closure and hydrogen sulfide signal transduction.
Title: Hydrogen Sulfide Increases Production of NADPH Oxidase-Dependent Hydrogen Peroxide and Phospholipase D-Derived Phosphatidic Acid in Guard Cell Signaling.
RbohF is responsible for the RPK1-triggered superoxide production.
Title: The Protein Trio RPK1-CaM4-RbohF Mediates Transient Superoxide Production to Trigger Age-Dependent Cell Death in Arabidopsis.
this study revealed that the AtrbohF-dependent ROS signaling is required for melatonin-induced salinity tolerance via the reestablishment of ion and redox homeostasis
Title: The AtrbohF-dependent regulation of ROS signaling is required for melatonin-induced salinity tolerance in Arabidopsis.
The role of NADPH oxidases under cadmium (Cd) toxicity was studied using Arabidopsis thaliana mutants AtrbohC, AtrbohD and AtrbohF.
Title: NADPH oxidases differentially regulate ROS metabolism and nutrient uptake under cadmium toxicity.
differential spatio-temporal expression of the Rboh genes contributes to fine-tune RBOH/NADPH oxidase-dependent reactive oxygen species production and signaling in Arabidopsis immunity.
Title: The Arabidopsis NADPH oxidases RbohD and RbohF display differential expression patterns and contributions during plant immunity.
At-RBOHD nor At-RBOHF is involved in the synergism between abscissic acid and At-FLA4.
Title: FASCICLIN LIKE ARABINOGALACTAN PROTEIN 4 and RESPIRATORY BURST OXIDASE HOMOLOG D and F independently modulate abscisic acid signaling.
The involvement of hydrogen peroxide (H2O2) generated by nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidase) in the antioxidant defense system was assessed in salt-challenged Arabidopsis thaliana seedlings.
Title: NADPH oxidase-dependent H2O2 production is required for salt-induced antioxidant defense in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_105079.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables NAD(P)H oxidase H2O2-forming activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables NAD(P)H oxidase H2O2-forming activity	TAS Traceable Author Statement more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within abscisic acid-activated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within carbohydrate homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response by callose deposition	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ethylene-activated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within hydrogen peroxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within osmosensory signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of stomatal movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within respiratory burst involved in defense response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ethylene	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: respiratory burst oxidase protein F

NP_564821.1

respiratory burst oxidase protein F (RBOH F); FUNCTIONS IN: NAD(P)H oxidase activity; INVOLVED IN: in 10 processes; LOCATED IN: plasma membrane, integral to plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Cytochrome b245, heavy chain (InterPro:IPR000778), EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-hand-like domain (InterPro:IPR011992), Ferric reductase-like transmembrane component, N-terminal (InterPro:IPR013130), NADPH oxidase Respiratory burst (InterPro:IPR013623), Ferric reductase, NAD binding (InterPro:IPR013121), EF-HAND 2 (InterPro:IPR018249), FAD-binding 8 (InterPro:IPR013112), Riboflavin synthase-like beta-barrel (InterPro:IPR017938); BEST Arabidopsis thaliana protein match is: Riboflavin synthase-like superfamily protein (TAIR:AT4G11230.1); Has 2419 Blast hits to 2261 proteins in 348 species: Archae - 6; Bacteria - 265; Metazoa - 742; Fungi - 676; Plants - 525; Viruses - 0; Other Eukaryotes - 205 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

23769774..23776984

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_105079.3 → NP_564821.1 respiratory burst oxidase protein F [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_564821.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O48538, O80342, Q0WR97, Q9SH56

UniProtKB/TrEMBL

A0A178WLX0, A0A5S9WRV6, A0A654EWH5

Conserved Domains (6) summary

pfam08022
Location:624 → 740

FAD_binding_8; FAD-binding domain

pfam08030
Location:746 → 927

NAD_binding_6; Ferric reductase NAD binding domain

pfam01794
Location:435 → 582

Ferric_reduct; Ferric reductase like transmembrane component

pfam08414
Location:169 → 267

NADPH_Ox; Respiratory burst NADPH oxidase

pfam13499
Location:266 → 337

EF-hand_7; EF-hand domain pair

cl08302
Location:247 → 294

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...