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    SPO11-2 sporulation 11-2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842702, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SPO11-2
    Official Full Name
    sporulation 11-2
    Primary source
    TAIR:AT1G63990
    Locus tag
    AT1G63990
    See related
    Araport:AT1G63990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F22C12.24; F22C12_24; sporulation 11-2
    Summary
    Encodes AtSPO11-2, one of the three Arabidopsis homologues of the archaeal DNA topoisomerase VIA subunit (topo VIA). Required for meiotic recombination. Plants homozygous for atspo11-2 exhibit a severe sterility phenotype. Both male and female meiosis are severely disrupted in the atspo11-2 mutant, and this is associated with severe defects in synapsis during the first meiotic division and reduced meiotic recombination. AtSPO11-1 and AtSPO11-2 have overlapping functions (i.e. both required for meiotic recombination) whereas AtSPO11-3 functions in DNA replication. Required for double-strand break induction.
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    Genomic context

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    See SPO11-2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (23742842..23745385, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Copper transport protein family Neighboring gene isoprenoid F Neighboring gene D111/G-patch domain-containing protein Neighboring gene ncRNA Neighboring gene WRKY DNA-binding protein 56 Neighboring gene Serine protease inhibitor (SERPIN) family protein Neighboring gene Serine protease inhibitor (SERPIN) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heterologous Complementation of SPO11-1 and -2 Depends on the Splicing Pattern. Sprink T, et al. Int J Mol Sci, 2021 Aug 28. PMID 34502253, Free PMC Article
    2. The catalytically active tyrosine residues of both SPO11-1 and SPO11-2 are required for meiotic double-strand break induction in Arabidopsis. Hartung F, et al. Plant Cell, 2007 Oct. PMID 17965269, Free PMC Article
    3. Arabidopsis SPO11-2 functions with SPO11-1 in meiotic recombination. Stacey NJ, et al. Plant J, 2006 Oct. PMID 17018031
    4. MTOPVIB interacts with AtPRD1 and plays important roles in formation of meiotic DNA double-strand breaks in Arabidopsis. Tang Y, et al. Sci Rep, 2017 Aug 30. PMID 28855712, Free PMC Article
    5. A DNA topoisomerase VI-like complex initiates meiotic recombination. Vrielynck N, et al. Science, 2016 Feb 26. PMID 26917763

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Heterologous Complementation of SPO11-1 and -2 Depends on the Splicing Pattern.
      Title: Heterologous Complementation of SPO11-1 and -2 Depends on the Splicing Pattern.
    2. Data show that the catalytically active tyrosine residues of SPO11-2 are required for meiotic double-strand break induction in Arabidopsis.
      Title: The catalytically active tyrosine residues of both SPO11-1 and SPO11-2 are required for meiotic double-strand break induction in Arabidopsis.
    3. AtSPO11-1 and AtSPO11-2 genetically interact and function in meiotic recombination. [SPO11-2]
      Title: Arabidopsis SPO11-2 functions with SPO11-1 in meiotic recombination.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001334143.1
    NM_105072.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chiasma assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo sac development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in floral organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic DNA double-strand break formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    sporulation 11-2
    NP_176582.2
    • sporulation 11-2 (SPO11-2); FUNCTIONS IN: DNA topoisomerase (ATP-hydrolyzing) activity, DNA binding, catalytic activity, ATP binding; INVOLVED IN: in 11 processes; LOCATED IN: chromosome; CONTAINS InterPro DOMAIN/s: Spo11/DNA topoisomerase VI, subunit A, N-terminal (InterPro:IPR013049), Spo11/DNA topoisomerase VI, subunit A (InterPro:IPR002815); BEST Arabidopsis thaliana protein match is: Spo11/DNA topoisomerase VI, subunit A protein (TAIR:AT5G02820.1); Has 890 Blast hits to 889 proteins in 304 species: Archae - 214; Bacteria - 14; Metazoa - 169; Fungi - 107; Plants - 162; Viruses - 0; Other Eukaryotes - 224 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      23742842..23745385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105072.3 → NP_176582.2  sporulation 11-2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176582.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M4A1, Q9SH50
      UniProtKB/TrEMBL
      A0A5S9WPD6, A0A654EL66
      Conserved Domains (1) summary
      PLN00060
      Location:1 → 383
      PLN00060; meiotic recombination protein SPO11-2; Provisional

    2. NM_001334143.1 → NP_001320320.1  sporulation 11-2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AMF9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M4A1.1

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