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    RAD3-like DNA-binding helicase protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844335, updated on 18-Sep-2024

    Summary

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    Official Full Name
    RAD3-like DNA-binding helicase protein
    Primary source
    TAIR:AT1G79950
    Locus tag
    AT1G79950
    See related
    Araport:AT1G79950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F18B13.3; F18B13_3
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    19
    Sequence:
    Chromosome: 1; NC_003070.9 (30073524..30080778)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene heat shock protein 91 Neighboring gene DnaJ / Sec63 Brl domains-containing protein Neighboring gene ovate family protein 14 Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RTEL1 is required for silencing and epigenome stability. Olivier M, et al. Nucleic Acids Res, 2023 Sep 8. PMID 37471026, Free PMC Article
    2. Deficiency of the Arabidopsis helicase RTEL1 triggers a SOG1-dependent replication checkpoint in response to DNA cross-links. Hu Z, et al. Plant Cell, 2015 Jan. PMID 25595823, Free PMC Article
    3. The Arabidopsis thaliana homolog of the helicase RTEL1 plays multiple roles in preserving genome stability. Recker J, et al. Plant Cell, 2014 Dec. PMID 25516598, Free PMC Article
    4. RAD51 and RTEL1 compensate telomere loss in the absence of telomerase. Olivier M, et al. Nucleic Acids Res, 2018 Mar 16. PMID 29346668, Free PMC Article
    5. The RTR Complex Partner RMI2 and the DNA Helicase RTEL1 Are Both Independently Involved in Preserving the Stability of 45S rDNA Repeats in Arabidopsis thaliana. Röhrig S, et al. PLoS Genet, 2016 Oct. PMID 27760121, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RTEL1 is required for silencing and epigenome stability.
      Title: RTEL1 is required for silencing and epigenome stability.
    2. RAD51 and RTEL1 compensate telomere loss in the absence of telomerase.
      Title: RAD51 and RTEL1 compensate telomere loss in the absence of telomerase.
    3. The RTEL1 homolog in Arabidopsis thaliana plays multiple roles in preserving genome stability.
      Title: The Arabidopsis thaliana homolog of the helicase RTEL1 plays multiple roles in preserving genome stability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001334942.1
    NM_001334943.1
    NM_106644.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of rDNA IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maintenance of rDNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within recombinational repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in recombinational repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RAD3-like DNA-binding helicase protein
    NP_178113.3
    • RAD3-like DNA-binding helicase protein; FUNCTIONS IN: in 6 functions; INVOLVED IN: regulation of transcription, DNA-dependent, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DEAD2 (InterPro:IPR010614), DEAD-like helicase, N-terminal (InterPro:IPR014001), Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type (InterPro:IPR014013), Helicase-like, DEXD box c2 type (InterPro:IPR006554), DNA helicase (DNA repair), Rad3 type (InterPro:IPR013020), Helicase, ATP-dependent, c2 type (InterPro:IPR006555), Paired amphipathic helix (InterPro:IPR003822); BEST Arabidopsis thaliana protein match is: RAD3-like DNA-binding helicase protein (TAIR:AT1G20720.1); Has 3149 Blast hits to 2661 proteins in 831 species: Archae - 223; Bacteria - 987; Metazoa - 718; Fungi - 431; Plants - 207; Viruses - 6; Other Eukaryotes - 577 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      30073524..30080778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001334938.1 → NP_001321162.1  RAD3-like DNA-binding helicase protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WHW1, A0A1P8AQ53

    2. NM_001334939.1 → NP_001321157.1  RAD3-like DNA-binding helicase protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WHW1, A0A1P8AQ53

    3. NM_001334940.1 → NP_001321160.1  RAD3-like DNA-binding helicase protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WHW1, A0A1P8AQ45

    4. NM_001334941.1 → NP_001321161.1  RAD3-like DNA-binding helicase protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WHW1, A0A1P8AQ45

    5. NM_106644.4 → NP_178113.3  RAD3-like DNA-binding helicase protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178113.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HQE2, Q9CA97, Q9SSD8
      UniProtKB/TrEMBL
      A0A178WIM0, A0A5S9WVX2, A0A654ES14
      Conserved Domains (2) summary
      cd13932
      Location:928 → 1032
      HN_RTEL1; harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL)
      TIGR00604
      Location:56 → 762
      rad3; DNA repair helicase (rad3)

    6. NM_001334942.1 → NP_001321158.1  RAD3-like DNA-binding helicase protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AQ29, A0A5S9WVX2

    7. NM_001334943.1 → NP_001321159.1  RAD3-like DNA-binding helicase protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WHW1, A0A1P8AQ53
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4HQE2.1

    Gene LinkOut

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