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    basic helix-loop-helix (bHLH) DNA-binding superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839545, updated on 18-Sep-2024

    Summary

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    Official Full Name
    basic helix-loop-helix (bHLH) DNA-binding superfamily protein
    Primary source
    TAIR:AT1G01260
    Locus tag
    AT1G01260
    See related
    Araport:AT1G01260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F6F3.7; F6F3_7; JAM2; Jasmonate Associated MYC2 LIKE 2
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (108946..111699)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene tRNA-Gln Neighboring gene cytochrome P450, family 703, subfamily A, polypeptide 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Basic helix-loop-helix transcription factors JASMONATE-ASSOCIATED MYC2-LIKE1 (JAM1), JAM2, and JAM3 are negative regulators of jasmonate responses in Arabidopsis. Sasaki-Sekimoto Y, et al. Plant Physiol, 2013 Sep. PMID 23852442, Free PMC Article
    2. The bHLH subgroup IIId factors negatively regulate jasmonate-mediated plant defense and development. Song S, et al. PLoS Genet, 2013. PMID 23935516, Free PMC Article
    3. Enhanced Y1H assays for Arabidopsis. Gaudinier A, et al. Nat Methods, 2011 Oct 30. PMID 22037706, Free PMC Article
    4. The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity. Heim MA, et al. Mol Biol Evol, 2003 May. PMID 12679534
    5. A PXY-Mediated Transcriptional Network Integrates Signaling Mechanisms to Control Vascular Development in Arabidopsis. Smit ME, et al. Plant Cell, 2020 Feb. PMID 31806676, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. JAM2 (At1g01260) negatively regulates the JA response in a manner that is mostly antagonistic to MYC2.
      Title: Basic helix-loop-helix transcription factors JASMONATE-ASSOCIATED MYC2-LIKE1 (JAM1), JAM2, and JAM3 are negative regulators of jasmonate responses in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001083971.1
    NM_001197954.2
    NM_100009.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    basic helix-loop-helix (bHLH) DNA-binding superfamily protein
    NP_001077440.1
    • basic helix-loop-helix (bHLH) DNA-binding superfamily protein; FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: ABA-inducible BHLH-type transcription factor (TAIR:AT2G46510.1); Has 3647 Blast hits to 3273 proteins in 223 species: Archae - 0; Bacteria - 2; Metazoa - 174; Fungi - 93; Plants - 3336; Viruses - 0; Other Eukaryotes - 42 (source: NCBI BLink).
    NP_001184883.1
    • basic helix-loop-helix (bHLH) DNA-binding superfamily protein; FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: ABA-inducible BHLH-type transcription factor (TAIR:AT2G46510.1).
    NP_171634.1
    • basic helix-loop-helix (bHLH) DNA-binding superfamily protein; FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: ABA-inducible BHLH-type transcription factor (TAIR:AT2G46510.1); Has 3647 Blast hits to 3273 proteins in 223 species: Archae - 0; Bacteria - 2; Metazoa - 174; Fungi - 93; Plants - 3336; Viruses - 0; Other Eukaryotes - 42 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      108946..111699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001197954.2 → NP_001184883.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001184883.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S3F5, Q9LNJ5
      UniProtKB/TrEMBL
      A0A178WJW5, A0A5S9S1V3
      Conserved Domains (2) summary
      cd11449
      Location:426 → 503
      bHLH_AtAIB_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein ABA-INDUCIBLE bHLH-TYPE (AIB) and similar proteins
      pfam14215
      Location:48 → 236
      bHLH-MYC_N; bHLH-MYC and R2R3-MYB transcription factors N-terminal

    2. NM_100009.3 → NP_171634.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171634.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S3F5, Q9LNJ5
      UniProtKB/TrEMBL
      A0A178WJW5, A0A5S9S1V3
      Conserved Domains (2) summary
      cd11449
      Location:426 → 503
      bHLH_AtAIB_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein ABA-INDUCIBLE bHLH-TYPE (AIB) and similar proteins
      pfam14215
      Location:48 → 236
      bHLH-MYC_N; bHLH-MYC and R2R3-MYB transcription factors N-terminal

    3. NM_001083971.1 → NP_001077440.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077440.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S3F5, Q9LNJ5
      UniProtKB/TrEMBL
      A0A178WJW5, A0A5S9S1V3
      Conserved Domains (2) summary
      cd11449
      Location:426 → 503
      bHLH_AtAIB_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein ABA-INDUCIBLE bHLH-TYPE (AIB) and similar proteins
      pfam14215
      Location:48 → 236
      bHLH-MYC_N; bHLH-MYC and R2R3-MYB transcription factors N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LNJ5.1

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