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    SCO2 protein disulfide isomerase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821456, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SCO2
    Official Full Name
    protein disulfide isomerase
    Primary source
    TAIR:AT3G19220
    Locus tag
    AT3G19220
    See related
    Araport:AT3G19220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CYO1; MVI11.22; SHI-YO-U MEANS COTYLEDON IN JAPANESE; SNOWY COTYLEDON 2
    Summary
    Encodes a zinc finger protein that is similar to a subgroup of DnaJ and is involved in cotyledon chloroplast biogenesis. Cyo1 is localized to the thylakoid membrane and has protein disulfide isomerase activity in vivo.Cyo1 is more highly expressed in light grown seedlings. Loss of function mutants have albino cotyledons and abnormal plastids.
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    Genomic context

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    See SCO2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (6659155..6660852)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene DNA repair/recombination protein Neighboring gene Leucine-rich repeat (LRR) family protein Neighboring gene tRNA-Arg Neighboring gene Vacuolar import/degradation, Vid27-related protein Neighboring gene transmembrane protein, putative (DUF677)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of the protein disulfide isomerase AtCYO1 in chloroplasts slows dark-induced senescence in Arabidopsis. Tominaga J, et al. BMC Plant Biol, 2018 May 4. PMID 29728061, Free PMC Article
    2. SNOWY COTYLEDON 2 Promotes Chloroplast Development and Has a Role in Leaf Variegation in Both Lotus japonicus and Arabidopsis thaliana. Zagari N, et al. Mol Plant, 2017 May 1. PMID 28286296
    3. Snowy cotyledon 2: the identification of a zinc finger domain protein essential for chloroplast development in cotyledons but not in true leaves. Albrecht V, et al. Plant Mol Biol, 2008 Apr. PMID 18209955
    4. Arabidopsis cotyledon-specific chloroplast biogenesis factor CYO1 is a protein disulfide isomerase. Shimada H, et al. Plant Cell, 2007 Oct. PMID 17921316, Free PMC Article
    5. The SCO2 protein disulphide isomerase is required for thylakoid biogenesis and interacts with LHCB1 chlorophyll a/b binding proteins which affects chlorophyll biosynthesis in Arabidopsis seedlings. Tanz SK, et al. Plant J, 2012 Mar. PMID 22040291

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ectopic overexpression has a negative impact on the initiation of chlorophyll degradation and proteolysis within chloroplasts
      Title: Overexpression of the protein disulfide isomerase AtCYO1 in chloroplasts slows dark-induced senescence in Arabidopsis.
    2. results indicate that SCO2 plays a distinct role in PSII assembly or repair and constitutes a novel factor involved in leaf variegation
      Title: SNOWY COTYLEDON 2 Promotes Chloroplast Development and Has a Role in Leaf Variegation in Both Lotus japonicus and Arabidopsis thaliana.
    3. SCO2 interacts with LHCB1 proteins and is co-expressed with genes encoding proteins of the tetrapyrrole biosynthesis pathway. Mutations in sco2 affect the accumulation of the chlorophyll precursor protochlorophyllide.
      Title: The SCO2 protein disulphide isomerase is required for thylakoid biogenesis and interacts with LHCB1 chlorophyll a/b binding proteins which affects chlorophyll biosynthesis in Arabidopsis seedlings.
    4. Data indicate that CYO1(At3g19220) has protein disulfide isomerase activity, and suggest that CYO1 has a chaperone-like activity required for thylakoid biogenesis in cotyledons
      Title: Arabidopsis cotyledon-specific chloroplast biogenesis factor CYO1 is a protein disulfide isomerase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_112809.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein disulfide isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast thylakoid membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein disulfide isomerase
    NP_566627.1
    • SNOWY COTYLEDON 2 (SCO2); Has 34 Blast hits to 34 proteins in 14 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 34; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6659155..6660852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112809.4 → NP_566627.1  protein disulfide isomerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566627.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93YN0
      UniProtKB/TrEMBL
      A0A178VCM9, A0A5S9XDK5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93YN0.1

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