HSP60 heat shock protein 60 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: HSP60
Official Full Name: heat shock protein 60
Primary source: TAIR:AT3G23990
Locus tag: AT3G23990
See related: Araport:AT3G23990
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: heat shock protein 60; HEAT SHOCK PROTEIN 60-3B; HSP60-3B
Summary: mitochondrial chaperonin HSP. assist in rapid assembly of the oligomeric protein structures in the mitochondria.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See HSP60 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 16

Sequence:: Chromosome: 3; NC_003074.8 (8668772..8672578)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSP60s interacted with WTF9, which was further confirmed by a pull-down assay.
Title: Mitochondrial Heat Shock Protein 60s Interact with What's This Factor 9 to Regulate RNA Splicing of ccmFC and rpl2.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_113304.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP binding	HDA more info	PubMed
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables RNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables copper ion binding	HDA more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Group II intron splicing	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within chaperone-mediated protein complex assembly	TAS Traceable Author Statement more info
acts_upstream_of_or_within mitochondrion organization	TAS Traceable Author Statement more info	PubMed
involved_in protein refolding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to heat	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in cytosolic ribosome	HDA more info	PubMed
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
colocalizes_with mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: heat shock protein 60

NP_189041.1

heat shock protein 60 (HSP60); FUNCTIONS IN: copper ion binding, ATP binding; INVOLVED IN: response to cadmium ion, response to cyclopentenone, chaperone-mediated protein complex assembly, response to heat, mitochondrion organization; LOCATED IN: cytosol, cytosolic ribosome, mitochondrion, plasma membrane, mitochondrial matrix; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Chaperonin Cpn60/TCP-1 (InterPro:IPR002423), Chaperonin Cpn60, conserved site (InterPro:IPR018370), Chaperonin Cpn60 (InterPro:IPR001844); BEST Arabidopsis thaliana protein match is: heat shock protein 60-2 (TAIR:AT2G33210.1); Has 33706 Blast hits to 33652 proteins in 8680 species: Archae - 676; Bacteria - 21745; Metazoa - 1618; Fungi - 1515; Plants - 790; Viruses - 2; Other Eukaryotes - 7360 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

8668772..8672578

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_113304.5 → NP_189041.1 heat shock protein 60 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_189041.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29197, Q9LIQ8

UniProtKB/TrEMBL

A0A178VEN0, A0A5S9XF49

Conserved Domains (1) summary

cd03344
Location:34 → 554

GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...