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    GRP4 glycine-rich RNA-binding protein 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821966, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GRP4
    Official Full Name
    glycine-rich RNA-binding protein 4
    Primary source
    TAIR:AT3G23830
    Locus tag
    AT3G23830
    See related
    Araport:AT3G23830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtGRP4; glycine-rich RNA-binding protein 4; GR-RBP4
    Summary
    encodes a glycine-rich RNA binding protein. Gene expression is induced by cold and reduced by ionic (salt) and non-ionic (mannitol) osmotic stress. Lines overexpressing the gene are slightly more tolerant to osmotic stress during germination.
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    Genomic context

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    See GRP4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (8606429..8608297, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene UDP-D-glucuronate 4-epimerase 6 Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene GTP-binding protein-like protein Neighboring gene magnesium transporter NIPA (DUF803)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural determinants crucial to the RNA chaperone activity of glycine-rich RNA-binding proteins 4 and 7 in Arabidopsis thaliana during the cold adaptation process. Kwak KJ, et al. J Exp Bot, 2011 Jul. PMID 21511907, Free PMC Article
    2. A Plant SMALL RNA-BINDING PROTEIN 1 Family Mediates Cell-to-Cell Trafficking of RNAi Signals. Yan Y, et al. Mol Plant, 2020 Feb 3. PMID 31812689
    3. Characterization of transgenic Arabidopsis plants overexpressing GR-RBP4 under high salinity, dehydration, or cold stress. Kwak KJ, et al. J Exp Bot, 2005 Nov. PMID 16207746
    4. A family of RRM-type RNA-binding proteins specific to plant mitochondria. Vermel M, et al. Proc Natl Acad Sci U S A, 2002 Apr 30. PMID 11972043, Free PMC Article
    5. Cold shock domain proteins and glycine-rich RNA-binding proteins from Arabidopsis thaliana can promote the cold adaptation process in Escherichia coli. Kim JS, et al. Nucleic Acids Res, 2007. PMID 17169986, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Domain sequences encompassing the RNA recognition motif and the overall structure of GRPs (AtGRP4 harboring no RNA chaperone activity and AtGRP7 harboring such activity) are critical to chaperone activity during the cold adaptation process in cells.
      Title: Structural determinants crucial to the RNA chaperone activity of glycine-rich RNA-binding proteins 4 and 7 in Arabidopsis thaliana during the cold adaptation process.
    2. results indicate that GR-RBP4 contributes differently to altered germination and seedling growth of Arabidopsis plants under various stress conditions
      Title: Characterization of transgenic Arabidopsis plants overexpressing GR-RBP4 under high salinity, dehydration, or cold stress.
    Submit: New GeneRIF Correction

    General gene information

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    NM_113288.3
    NM_180298.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables siRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in extracellular transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in miRNA transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrial RNA modification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glycine-rich RNA-binding protein 4
    NP_189025.1
    • glycine-rich RNA-binding protein 4 (GRP4); CONTAINS InterPro DOMAIN/s: RNA recognition motif, glycine rich protein (InterPro:IPR015465), RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: glycine-rich RNA-binding protein 2 (TAIR:AT4G13850.3); Has 39778 Blast hits to 39772 proteins in 2962 species: Archae - 777; Bacteria - 23781; Metazoa - 723; Fungi - 392; Plants - 1153; Viruses - 36; Other Eukaryotes - 12916 (source: NCBI BLink).
    NP_850629.1
    • glycine-rich RNA-binding protein 4 (GRP4); CONTAINS InterPro DOMAIN/s: RNA recognition motif, glycine rich protein (InterPro:IPR015465), RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: glycine-rich RNA-binding protein 2 (TAIR:AT4G13850.3); Has 79 Blast hits to 79 proteins in 22 species: Archae - 3; Bacteria - 0; Metazoa - 1; Fungi - 0; Plants - 72; Viruses - 1; Other Eukaryotes - 2 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      8606429..8608297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180298.4 → NP_850629.1  glycine-rich RNA-binding protein 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850629.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A6B9JFL3, Q8LDS0, Q9LIS2
      UniProtKB/TrEMBL
      A0A178VD35, A0A7G2EKR9
      Conserved Domains (1) summary
      PLN03134
      Location:1 → 122
      PLN03134; glycine-rich RNA-binding protein 4; Provisional

    2. NM_113288.3 → NP_189025.1  glycine-rich RNA-binding protein 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189025.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A6B9JFL3, Q8LDS0, Q9LIS2
      UniProtKB/TrEMBL
      A0A178VD35, A0A7G2EKR9
      Conserved Domains (1) summary
      PLN03134
      Location:1 → 122
      PLN03134; glycine-rich RNA-binding protein 4; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LIS2.1

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