GAMMA-VPE gamma vacuolar processing enzyme [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GAMMA-VPE
Official Full Name: gamma vacuolar processing enzyme
Primary source: TAIR:AT4G32940
Locus tag: AT4G32940
See related: Araport:AT4G32940
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F26P21.60; F26P21_60; gamma vacuolar processing enzyme; GAMMAVPE
Summary: Encodes a vacuolar processing enzyme belonging to a novel group of cysteine proteinases that is expressed in vegetative organs and is upregulated in association with various types of cell death and under stressed conditions. They are essential in processing seed storage proteins and for mediating the susceptible response of toxin-induced cell death.
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Genomic context

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See GAMMA-VPE in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 9

Sequence:: Chromosome: 4; NC_003075.7 (15900270..15903523, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

gammaVPE is a crucial processing enzyme for xylem fiber cells PCD during stem development
Title: γVPE plays an important role in programmed cell death for xylem fiber cells by activating protease CEP1 maturation in Arabidopsis thaliana.
The presented integrative mechanisms of proteolysis and ligation (transpeptidation) explain the interdependence of legumain and its preferred substrates and provide a rational framework for engineering optimized proteases, ligases, and substrates. [legumain gamma]
Title: Structural analyses of Arabidopsis thaliana legumain γ reveal differential recognition and processing of proteolysis and ligation substrates.
the activation of Arabidopsis gamma-VPE was mediated by MPK6 and played an important role in heat shock-induced Arabidopsis programmed cell death
Title: MAP Kinase 6-mediated activation of vacuolar processing enzyme modulates heat shock-induced programmed cell death in Arabidopsis.
gammaVPE is the proteinase that exhibits a caspase-1 activity
Title: Vacuolar processing enzyme is essential for mycotoxin-induced cell death in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_119448.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in leaf senescence	IEP Inferred from Expression Pattern more info	PubMed
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in response to ethylene	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to jasmonic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salicylic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to wounding	IEP Inferred from Expression Pattern more info	PubMed
involved_in vacuolar protein processing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within vacuolar protein processing	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	ISM Inferred from Sequence Model more info
located_in lytic vacuole	IDA Inferred from Direct Assay more info	PubMed
located_in protein storage vacuole	ISS Inferred from Sequence or Structural Similarity more info
located_in vacuole	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: gamma vacuolar processing enzyme

NP_195020.1

gamma vacuolar processing enzyme (GAMMA-VPE); CONTAINS InterPro DOMAIN/s: Peptidase C13, legumain (InterPro:IPR001096); BEST Arabidopsis thaliana protein match is: alpha-vacuolar processing enzyme (TAIR:AT2G25940.1); Has 789 Blast hits to 787 proteins in 239 species: Archae - 4; Bacteria - 12; Metazoa - 277; Fungi - 115; Plants - 257; Viruses - 0; Other Eukaryotes - 124 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

15900270..15903523 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119448.4 → NP_195020.1 gamma vacuolar processing enzyme [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195020.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q39119, Q93VM0, Q9SB73

UniProtKB/TrEMBL

A0A178UU68, A0A5S9XY30, A0A7G2F7N1

Conserved Domains (2) summary

pfam01650
Location:59 → 330

Peptidase_C13; Peptidase C13 family

cd21115
Location:356 → 477

legumain_C; C-terminal prodomain of legumain