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    ABCD1 peroxisomal ABC transporter 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830144, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ABCD1
    Official Full Name
    peroxisomal ABC transporter 1
    Primary source
    TAIR:AT4G39850
    Locus tag
    AT4G39850
    See related
    Araport:AT4G39850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    acetate non-utilizing 2; ACN2; Arabidopsis thaliana ATP-binding cassette D1; AtABCD1; ATP-binding cassette D1; COMATOSE; CTS; PED3; peroxisomal ABC transporter 1; PEROXISOME DEFECTIVE 3; PXA1; T5J17.20; T5J17_20
    Summary
    Encodes a peroxisomal protein of the ATP binding cassette (ABC) transporter class (PMP subfamily) with significant identity to the human X-linked adrenoleukodystrophy protein (ALDP). The gene product promotes germination and represses embryo dormancy. ABI3, ABA1, FUS3 and LEC1 are epistatic to this gene. Mutants accumulate fatty acyl CoA suggesting a defect in uptake of fatty acyl CoA into the peroxisome.
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    Genomic context

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    See ABCD1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    26
    Sequence:
    Chromosome: 4; NC_003075.7 (18488434..18497266)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene cell wall integrity/stress response component-like protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene hematological/neurological-like protein Neighboring gene ncRNA Neighboring gene tRNA-Arg

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutagenesis separates ATPase and thioesterase activities of the peroxisomal ABC transporter, Comatose. Carrier DJ, et al. Sci Rep, 2019 Jul 19. PMID 31324846, Free PMC Article
    2. Ped3p is a peroxisomal ATP-binding cassette transporter that might supply substrates for fatty acid beta-oxidation. Hayashi M, et al. Plant Cell Physiol, 2002 Jan. PMID 11828016
    3. Control of germination and lipid mobilization by COMATOSE, the Arabidopsis homologue of human ALDP. Footitt S, et al. EMBO J, 2002 Jun 17. PMID 12065405, Free PMC Article
    4. Jasmonic acid levels are reduced in COMATOSE ATP-binding cassette transporter mutants. Implications for transport of jasmonate precursors into peroxisomes. Theodoulou FL, et al. Plant Physiol, 2005 Mar. PMID 15761209, Free PMC Article
    5. A peroxisomal ABC transporter promotes seed germination by inducing pectin degradation under the control of ABI5. Kanai M, et al. Plant J, 2010 Jun 1. PMID 20345608

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutagenesis separates ATPase and thioesterase activities of the peroxisomal ABC transporter, Comatose.
      Title: Mutagenesis separates ATPase and thioesterase activities of the peroxisomal ABC transporter, Comatose.
    2. Peroxisomal ATP-binding cassette transporter COMATOSE is required for the accumulation of benzoylated secondary metabolites in Arabidopsis seeds, including benzoylated glucosinolates and substituted hydroxybenzoylcholines.
      Title: Peroxisomal ATP-binding cassette transporter COMATOSE and the multifunctional protein abnormal INFLORESCENCE MERISTEM are required for the production of benzoylated metabolites in Arabidopsis seeds.
    3. Data indicate that CGI-58 (At4g24160) interacts with PXA1 into peroxisomes for their subsequent metabolism by beta-oxidation, including fatty acids and lipophilic hormone precursors of the jasmonate and auxin biosynthetic pathways.
      Title: The α/β hydrolase CGI-58 and peroxisomal transport protein PXA1 coregulate lipid homeostasis and signaling in Arabidopsis.
    4. Pseudo half-molecules of the ABC transporter, COMATOSE, bind Pex19 and target to peroxisomes independently but are both required for activity
      Title: Pseudo half-molecules of the ABC transporter, COMATOSE, bind Pex19 and target to peroxisomes independently but are both required for activity.
    5. The Arabidopsis peroxisomal ABC transporter, comatose, complements the Saccharomyces cerevisiae pxa1 pxa2Delta mutant for metabolism of long-chain fatty acids and exhibits fatty acyl-CoA-stimulated ATPase activity.
      Title: The Arabidopsis peroxisomal ABC transporter, comatose, complements the Saccharomyces cerevisiae pxa1 pxa2Delta mutant for metabolism of long-chain fatty acids and exhibits fatty acyl-CoA-stimulated ATPase activity.
    6. PED3 promotes seed germination by suppressing polygalacturonase inhibiting proteins under the control of ABI5.
      Title: A peroxisomal ABC transporter promotes seed germination by inducing pectin degradation under the control of ABI5.
    7. pxa1 plants accumulate free fatty acids in dark-treated leaves. Extended dark conditions are lethal for pxa1 plants.
      Title: The ABC transporter PXA1 and peroxisomal beta-oxidation are vital for metabolism in mature leaves of Arabidopsis during extended darkness.
    8. Results demonstrate that COMATOSE functions can be separated by mutagenesis and the structural model provides a framework for interpretation of phenotypic data.
      Title: Mutations in the Arabidopsis peroxisomal ABC transporter COMATOSE allow differentiation between multiple functions in planta: insights from an allelic series.
    9. pxa1 mutants are sucrose-dependent and IBA resistant following germination, probably because of a failure to import beta-oxidation substrates into peroxisomes.
      Title: The Arabidopsis pxa1 mutant is defective in an ATP-binding cassette transporter-like protein required for peroxisomal fatty acid beta-oxidation.
    10. Beta-oxidation could play a role in the mobilization of lipids in both pollen and female tissues. Expression of CTS in either male or female tissues was sufficient to support pollen tube growth in vivo.
      Title: The COMATOSE ATP-binding cassette transporter is required for full fertility in Arabidopsis.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_120148.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ABC-type fatty-acyl-CoA transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty-acyl-CoA transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in glyoxysomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxisomal ABC transporter 1
    NP_001190972.1
    • peroxisomal ABC transporter 1 (PXA1); CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, N-terminal (InterPro:IPR010509), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: ABC transporter family protein (TAIR:AT1G54350.1).
    NP_001190973.1
    • peroxisomal ABC transporter 1 (PXA1); CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter, N-terminal (InterPro:IPR010509), ABC transporter-like (InterPro:IPR003439), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: ABC transporter family protein (TAIR:AT1G54350.1).
    NP_568072.1
    • peroxisomal ABC transporter 1 (PXA1); CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter, N-terminal (InterPro:IPR010509), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: ABC transporter family protein (TAIR:AT1G54350.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      18488434..18497266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001204043.2 → NP_001190972.1  peroxisomal ABC transporter 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190972.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V4N7, F4JJ27
      Conserved Domains (4) summary
      PRK13538
      Location:1129 → 1335
      PRK13538; cytochrome c biogenesis protein CcmA; Provisional
      cd03223
      Location:448 → 656
      ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
      COG1132
      Location:109 → 651
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      pfam06472
      Location:89 → 361
      ABC_membrane_2; ABC transporter transmembrane region 2

    2. NM_001342558.1 → NP_001328232.1  peroxisomal ABC transporter 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VWH7, Q94FB9, Q9SMR8
      UniProtKB/TrEMBL
      A0A178V4N7

    3. NM_001204044.1 → NP_001190973.1  peroxisomal ABC transporter 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190973.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V4N7, F4JJ28
      Conserved Domains (4) summary
      PRK13538
      Location:1115 → 1321
      PRK13538; cytochrome c biogenesis protein CcmA; Provisional
      cd03223
      Location:448 → 656
      ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
      COG1132
      Location:109 → 651
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      pfam06472
      Location:89 → 361
      ABC_membrane_2; ABC transporter transmembrane region 2

    4. NM_120148.3 → NP_568072.1  peroxisomal ABC transporter 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568072.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VWH7, Q94FB9, Q9SMR8
      UniProtKB/TrEMBL
      A0A178V4N7
      Conserved Domains (4) summary
      PRK13538
      Location:1114 → 1320
      PRK13538; cytochrome c biogenesis protein CcmA; Provisional
      cd03223
      Location:448 → 656
      ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
      COG1132
      Location:109 → 651
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      pfam06472
      Location:89 → 361
      ABC_membrane_2; ABC transporter transmembrane region 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94FB9.1

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