U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    EIF3E eukaryotic translation initiation factor 3E [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824896, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    EIF3E
    Official Full Name
    eukaryotic translation initiation factor 3E
    Primary source
    TAIR:AT3G57290
    Locus tag
    AT3G57290
    See related
    Araport:AT3G57290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATEIF3E-1; ATINT6; eukaryotic translation initiation factor 3E; INT-6; INT6; TIF3E1
    Summary
    Encodes a protein that is found in not only the eif3 complex but also in association with subunits of the COP9 signalosome. eIF3e appears to be subjected to proteasome-dependent degradation that requires the PCI domain of eIF3e. The level of eIF3e present in cells appears to affect the rate of translation.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See EIF3E in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    8
    Sequence:
    Chromosome: 3; NC_003074.8 (21196517..21199319, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene beta-1,3-glucanase 1 Neighboring gene Transmembrane proteins 14C Neighboring gene DNA helicase INO80-like protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene threonine-tRNA ligase 2 Neighboring gene autoinhibited Ca2+-ATPase 11

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Arabidopsis eIF3e is regulated by the COP9 signalosome and has an impact on development and protein translation. Yahalom A, et al. Plant J, 2008 Jan. PMID 18067529
    2. The Arabidopsis eukaryotic translation initiation factor 3, subunit F (AteIF3f), is required for pollen germination and embryogenesis. Xia C, et al. Plant J, 2010 Jul. PMID 20444226, Free PMC Article
    3. Arabidopsis eIF3e (INT-6) associates with both eIF3c and the COP9 signalosome subunit CSN7. Yahalom A, et al. J Biol Chem, 2001 Jan 5. PMID 11029466
    4. Translational regulation via 5' mRNA leader sequences revealed by mutational analysis of the Arabidopsis translation initiation factor subunit eIF3h. Kim TH, et al. Plant Cell, 2004 Dec. PMID 15548739, Free PMC Article
    5. Arabidopsis eIF3e interacts with subunits of the ribosome, Cop9 signalosome and proteasome. Paz-Aviram T, et al. Plant Signal Behav, 2008 Jun. PMID 19704582, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study concludes that the COP9 signalosome maintains a precise regulation of eIF3e levels, which is necessary for normal development in Arabidopsis
      Title: Arabidopsis eIF3e is regulated by the COP9 signalosome and has an impact on development and protein translation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_115589.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation repressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription initiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photomorphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    part_of cytosolic proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    eukaryotic translation initiation factor 3E
    NP_567047.1
    • eukaryotic translation initiation factor 3E (EIF3E); FUNCTIONS IN: protein binding, translation initiation factor activity; INVOLVED IN: flower development, response to salt stress, translation, photomorphogenesis, transcription initiation; LOCATED IN: signalosome, eukaryotic translation initiation factor 3 complex, nucleus, plasma membrane, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Translation initiation factor 3, subunit 6, eukaryotic (InterPro:IPR016650), Proteasome component (PCI) domain (InterPro:IPR000717), Eukaryotic translation initiation factor 3 (eIF3), subunit 6, N-terminal (InterPro:IPR019010); Has 641 Blast hits to 638 proteins in 243 species: Archae - 0; Bacteria - 2; Metazoa - 287; Fungi - 119; Plants - 138; Viruses - 0; Other Eukaryotes - 95 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21196517..21199319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115589.5 → NP_567047.1  eukaryotic translation initiation factor 3E [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567047.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C5Z3, Q9M2L8, Q9M4T7
      UniProtKB/TrEMBL
      A0A178VL03, A0A5S9XMA6
      Conserved Domains (1) summary
      cd21378
      Location:7 → 433
      eIF3E; eukaryotic translation initiation factor 3 subunit E
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5Z3.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools