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    CLC-C chloride channel C [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835052, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CLC-C
    Official Full Name
    chloride channel C
    Primary source
    TAIR:AT5G49890
    Locus tag
    AT5G49890
    See related
    Araport:AT5G49890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCLC-C; chloride channel C; CHLORIDE CHANNEL C; K9P8.3; K9P8_3
    Summary
    member of Anion channel protein family
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    Genomic context

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    See CLC-C in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (20288055..20292432, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mitotic checkpoint family protein Neighboring gene Beta-glucosidase, GBA2 type family protein Neighboring gene chloroplast heat shock protein 70-2 Neighboring gene Octicosapeptide/Phox/Bem1p family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis vacuolar anion transporter, AtCLCc, is involved in the regulation of stomatal movements and contributes to salt tolerance. Jossier M, et al. Plant J, 2010 Nov. PMID 20822503
    2. Quantitative trait loci analysis of nitrate storage in Arabidopsis leading to an investigation of the contribution of the anion channel gene, AtCLC-c, to variation in nitrate levels. Harada H, et al. J Exp Bot, 2004 Sep. PMID 15310822
    3. CLC-b-mediated NO-3/H+ exchange across the tonoplast of Arabidopsis vacuoles. von der Fecht-Bartenbach J, et al. Plant Cell Physiol, 2010 Jun. PMID 20430762
    4. Overexpression of PP2A-C5 that encodes the catalytic subunit 5 of protein phosphatase 2A in Arabidopsis confers better root and shoot development under salt conditions. Hu R, et al. Plant Cell Environ, 2017 Jan. PMID 27676158
    5. A family of putative chloride channels from Arabidopsis and functional complementation of a yeast strain with a CLC gene disruption. Hechenberger M, et al. J Biol Chem, 1996 Dec 27. PMID 8969232

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. essential for stomatal movement and salt tolerance by regulating chloride homeostasis
      Title: The Arabidopsis vacuolar anion transporter, AtCLCc, is involved in the regulation of stomatal movements and contributes to salt tolerance.
    2. Expression of AtCLC-c was down-regulated in the presence of nitrate, but ammonium had a much smaller effect while chloride and sulphate did not affect expression.
      Title: Quantitative trait loci analysis of nitrate storage in Arabidopsis leading to an investigation of the contribution of the anion channel gene, AtCLC-c, to variation in nitrate levels.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_124367.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables monoatomic anion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables voltage-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular anatomical structure TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    chloride channel C
    NP_199800.1
    • chloride channel C (CLC-C); FUNCTIONS IN: anion channel activity, voltage-gated chloride channel activity; INVOLVED IN: chloride transport, transmembrane transport; LOCATED IN: plant-type vacuole membrane, intracellular, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Chloride channel, core (InterPro:IPR014743), Chloride channel, voltage gated (InterPro:IPR001807), Chloride channel ClC-plant (InterPro:IPR002251), Cystathionine beta-synthase, core (InterPro:IPR000644), Twin-arginine translocation pathway, signal sequence (InterPro:IPR006311); BEST Arabidopsis thaliana protein match is: Voltage-gated chloride channel family protein (TAIR:AT5G33280.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      20288055..20292432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124367.4 → NP_199800.1  chloride channel C [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199800.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04753, O04837, Q96282
      UniProtKB/TrEMBL
      A0A178UHL0, A0A654G9K7
      Conserved Domains (2) summary
      cd03685
      Location:64 → 586
      ClC_6_like; ClC-6-like chloride channel proteins. This CD includes ClC-6, ClC-7 and ClC-B, C, D in plants. Proteins in this family are ubiquitous in eukarotes and their functions are unclear. They are expressed in intracellular organelles membranes. This family ...
      cd04591
      Location:599 → 766
      CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96282.1

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