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    TOPP2 type one serine/threonine protein phosphatase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836034, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TOPP2
    Official Full Name
    type one serine/threonine protein phosphatase 2
    Primary source
    TAIR:AT5G59160
    Locus tag
    AT5G59160
    See related
    Araport:AT5G59160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MNC17.9; MNC17_9; PPO; PROTOPORPHYRINOGEN OXIDASE; type one serine/threonine protein phosphatase 2
    Summary
    Encodes the catalytic subunit of a Type 1 phosphoprotein Ser/Thr phosphatase, expressed in roots, shoots and flowers.
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    Genomic context

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    See TOPP2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (23879236..23881840)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene BTB/POZ domain-containing protein Neighboring gene RAB GTPase homolog A2D Neighboring gene Proline-rich extensin-like family protein Neighboring gene DNA-directed RNA polymerase II

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of multiple type 1 phosphoprotein phosphatases in Arabidopsis thaliana. Smith RD, et al. Plant Mol Biol, 1993 Jan. PMID 7678768
    2. Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit. Templeton GW, et al. Biochem J, 2011 Apr 1. PMID 21222654
    3. Identification and functional characterization of inhibitor-3, a regulatory subunit of protein phosphatase 1 in plants. Takemiya A, et al. Plant Physiol, 2009 May. PMID 19329567, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001037026.1
    NM_125306.2
    NM_180887.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein dephosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    part_of protein phosphatase type 1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type one serine/threonine protein phosphatase 2
    NP_001032103.1
    • type one serine/threonine protein phosphatase 2 (TOPP2); CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: type one serine/threonine protein phosphatase 5 (TAIR:AT3G46820.1); Has 7217 Blast hits to 7021 proteins in 626 species: Archae - 78; Bacteria - 572; Metazoa - 2410; Fungi - 1415; Plants - 989; Viruses - 12; Other Eukaryotes - 1741 (source: NCBI BLink).
    NP_200724.1
    • type one serine/threonine protein phosphatase 2 (TOPP2); CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: type one serine/threonine protein phosphatase 5 (TAIR:AT3G46820.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_851218.1
    • type one serine/threonine protein phosphatase 2 (TOPP2); CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: type one serine/threonine protein phosphatase 5 (TAIR:AT3G46820.1); Has 7217 Blast hits to 7021 proteins in 626 species: Archae - 78; Bacteria - 572; Metazoa - 2410; Fungi - 1415; Plants - 989; Viruses - 12; Other Eukaryotes - 1741 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23879236..23881840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180887.5 → NP_851218.1  type one serine/threonine protein phosphatase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851218.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48482, Q24JM8, Q94B57
      UniProtKB/TrEMBL
      A0A178UGI0, A0A384KLS9, A0A7G2ET45, B9DHU3
      Conserved Domains (1) summary
      cd07414
      Location:14 → 304
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

    2. NM_001037026.1 → NP_001032103.1  type one serine/threonine protein phosphatase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001032103.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48482, Q24JM8, Q94B57
      UniProtKB/TrEMBL
      A0A178UGI0, A0A384KLS9, A0A7G2ET45, B9DHU3
      Conserved Domains (1) summary
      cd07414
      Location:14 → 304
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

    3. NM_125306.2 → NP_200724.1  type one serine/threonine protein phosphatase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200724.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48482, Q24JM8, Q94B57
      UniProtKB/TrEMBL
      A0A178UGI0, A0A384KLS9, A0A7G2ET45, B9DHU3
      Conserved Domains (1) summary
      cd07414
      Location:14 → 304
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48482.1

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