U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    INT4 inositol transporter 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827346, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    INT4
    Official Full Name
    inositol transporter 4
    Primary source
    TAIR:AT4G16480
    Locus tag
    AT4G16480
    See related
    Araport:AT4G16480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATINT4; DL4265W; FCAALL.375; inositol transporter 4
    Summary
    Encodes a high affinity H+:<i>myo</i>-inositol symporter. The only other compound shown to be transported was pinitol, a methylated derivative of <i>myo</i>-inositol.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See INT4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (9290403..9293379)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene tRNA-Leu Neighboring gene ARM repeat superfamily protein Neighboring gene Cystatin/monellin superfamily protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Arabidopsis INOSITOL TRANSPORTER4 mediates high-affinity H+ symport of myoinositol across the plasma membrane. Schneider S, et al. Plant Physiol, 2006 Jun. PMID 16603666, Free PMC Article
    2. Routes to the tonoplast: the sorting of tonoplast transporters in Arabidopsis mesophyll protoplasts. Wolfenstetter S, et al. Plant Cell, 2012 Jan. PMID 22253225, Free PMC Article
    3. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. C-terminal di-leucine motif in INT1 can reroute other proteins, such as INT4, SUCROSE TRANSPORTER2 (SUC2), or SWEET1, to the tonoplast.
      Title: Routes to the tonoplast: the sorting of tonoplast transporters in Arabidopsis mesophyll protoplasts.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_117746.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables carbohydrate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables myo-inositol:proton symporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    inositol transporter 4
    NP_193381.1
    • inositol transporter 4 (INT4); FUNCTIONS IN: carbohydrate transmembrane transporter activity, myo-inositol:hydrogen symporter activity, sugar:hydrogen symporter activity; INVOLVED IN: transport, transmembrane transport; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Sugar transporter, conserved site (InterPro:IPR005829), Major facilitator superfamily (InterPro:IPR020846), General substrate transporter (InterPro:IPR005828), Sugar/inositol transporter (InterPro:IPR003663), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: nositol transporter 3 (TAIR:AT2G35740.1); Has 51354 Blast hits to 41404 proteins in 2520 species: Archae - 707; Bacteria - 26083; Metazoa - 6832; Fungi - 11387; Plants - 4246; Viruses - 2; Other Eukaryotes - 2097 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      9290403..9293379
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341102.1 → NP_001328028.1  inositol transporter 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23492
      UniProtKB/TrEMBL
      A0A178V322, A0A5S9XTV8
      Conserved Domains (1) summary
      cd17360
      Location:33 → 547
      MFS_HMIT_like; H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily

    2. NM_001341103.1 → NP_001328029.1  inositol transporter 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23492
      UniProtKB/TrEMBL
      A0A178V322, A0A5S9XTV8
      Conserved Domains (1) summary
      cd17360
      Location:33 → 547
      MFS_HMIT_like; H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily

    3. NM_117746.4 → NP_193381.1  inositol transporter 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193381.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23492
      UniProtKB/TrEMBL
      A0A178V322, A0A5S9XTV8
      Conserved Domains (1) summary
      cd17360
      Location:33 → 547
      MFS_HMIT_like; H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O23492.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools