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    NLRC5 NLR family CARD domain containing 5 [ Homo sapiens (human) ]

    Gene ID: 84166, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NLRC5provided by HGNC
    Official Full Name
    NLR family CARD domain containing 5provided by HGNC
    Primary source
    HGNC:HGNC:29933
    See related
    Ensembl:ENSG00000140853 MIM:613537; AllianceGenome:HGNC:29933
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOD4; NOD27; CLR16.1
    Summary
    This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]
    Expression
    Broad expression in spleen (RPKM 23.6), lymph node (RPKM 20.1) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NLRC5 in Genome Data Viewer
    Location:
    16q13
    Exon count:
    55
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (56989557..57083520)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (62785869..62879790)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57023469..57117432)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:56995483-56996470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:56996471-56997458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10866 Neighboring gene Sharpr-MPRA regulatory region 2679 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57016890-57017390 Neighboring gene uncharacterized LOC124903696 Neighboring gene cholesteryl ester transfer protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57023277-57023776 Neighboring gene Sharpr-MPRA regulatory region 12884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10869 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57033747-57034248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10874 Neighboring gene CFAP69 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57060363-57060881 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10879 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10880 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:57095254-57096453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57103335-57104060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57104061-57104785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57137039-57137994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57139274-57139873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10882 Neighboring gene copine 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7523 Neighboring gene Sharpr-MPRA regulatory region 3054 Neighboring gene Sharpr-MPRA regulatory region 6435 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57183845-57184634 Neighboring gene proteasome activator subunit 3 interacting protein 1 Neighboring gene NANOG hESC enhancer GRCh37_chr16:57212532-57213113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10884

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. NLRC5 and autophagy combined as possible predictors in patients with endometriosis. Zhan L, et al. Fertil Steril, 2018 Oct. PMID 30316442
    2. NLRC5: A Potential Target for Central Nervous System Disorders. Zhang L, et al. Front Immunol, 2021. PMID 34220868, Free PMC Article
    3. NLRC5 controls basal MHC class I gene expression in an MHC enhanceosome-dependent manner. Neerincx A, et al. J Immunol, 2012 May 15. PMID 22490867
    4. NLRC5 alleviated OGD/R-induced PC12-cell injury by inhibiting activation of the TLR4/MyD88/NF-κB pathway. Zhang Z, et al. J Int Med Res, 2020 Aug. PMID 32790491, Free PMC Article
    5. NLRC5 promotes cell migration and invasion by activating the PI3K/AKT signaling pathway in endometrial cancer. Fan Y, et al. J Int Med Res, 2020 May. PMID 32431202, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic retention and degradation to inhibit MHC class I expression.
      Title: Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic retention and degradation to inhibit MHC class I expression.
    2. NLRC5 exerts anti-endometriosis effects through inhibiting ERbeta-mediated inflammatory response.
      Title: NLRC5 exerts anti-endometriosis effects through inhibiting ERβ-mediated inflammatory response.
    3. CircATXN7 regulates the proliferation and invasion of esophageal cancer cells through miR-4319/NLRC5.
      Title: CircATXN7 regulates the proliferation and invasion of esophageal cancer cells through miR-4319/NLRC5.
    4. NLRC5 promotes tumorigenesis by regulating the PI3K/AKT signaling pathway in cervical cancer.
      Title: NLRC5 promotes tumorigenesis by regulating the PI3K/AKT signaling pathway in cervical cancer.
    5. The balance between nuclear import and export of NLRC5 regulates MHC class I transactivation.
      Title: The balance between nuclear import and export of NLRC5 regulates MHC class I transactivation.
    6. Rescue of NLRC5 expression restores antigen processing machinery in head and neck cancer cells lacking functional STAT1 and p53.
      Title: Rescue of NLRC5 expression restores antigen processing machinery in head and neck cancer cells lacking functional STAT1 and p53.
    7. NLRC5 overexpression in ovarian tumors remodels the tumor microenvironment and increases T-cell reactivity toward autologous tumor-associated antigens.
      Title: NLRC5 overexpression in ovarian tumors remodels the tumor microenvironment and increases T-cell reactivity toward autologous tumor-associated antigens.
    8. USP14-mediated NLRC5 upregulation inhibits endothelial cell activation and inflammation in atherosclerosis.
      Title: USP14-mediated NLRC5 upregulation inhibits endothelial cell activation and inflammation in atherosclerosis.
    9. NLRC5 germline variants as potential pharmacogenomic markers for immune checkpoint inhibitors.
      Title: NLRC5 germline variants as potential pharmacogenomic markers for immune checkpoint inhibitors.
    10. NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity.
      Title: NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity.
    Submit: New GeneRIF Correction See all GeneRIFs (73)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
    EBI GWAS Catalog
    Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.
    EBI GWAS Catalog
    Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of NLR family, CARD domain containing 5 (NLRC5) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21709, FLJ39711

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to virus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of type I interferon-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of MHC class I biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of MHC class I biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of type I interferon-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of type II interferon-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of type II interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein NLRC5
    Names
    NOD-like receptor C5
    caterpiller protein 16.1
    nucleotide-binding oligomerization domain protein 4
    nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5
    nucleotide-binding oligomerization domains 27

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030337.3 RefSeqGene

      Range
      5073..99036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330552.2 → NP_001317481.1  protein NLRC5 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 4 both encode the same isoform (2).
      Source sequence(s)
      AA722775, AC009090, AC023825
      Consensus CDS
      CCDS81985.1
      UniProtKB/Swiss-Prot
      Q86WI3
      Related
      ENSP00000441727.1, ENST00000539144.5
      Conserved Domains (6) summary
      sd00033
      Location:1495 → 1516
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1436 → 1466
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1493 → 1793
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    2. NM_001384950.1 → NP_001371879.1  protein NLRC5 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variant 1, encodes isoform 1.
      Source sequence(s)
      AC009090, AC023825
      Consensus CDS
      CCDS10773.1
      UniProtKB/Swiss-Prot
      B5MEF1, C9JMD8, Q6P4A6, Q86VM7, Q86WI3, Q8NF42, Q8TEE2, Q8TEJ1, Q969L7
      Related
      ENSP00000509992.1, ENST00000688547.1
      Conserved Domains (6) summary
      sd00033
      Location:1524 → 1545
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1465 → 1495
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1522 → 1822
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    3. NM_001384951.1 → NP_001371880.1  protein NLRC5 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC009090, AC023825
      Consensus CDS
      CCDS81985.1
      Conserved Domains (6) summary
      sd00033
      Location:1495 → 1516
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1436 → 1466
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1493 → 1793
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    4. NM_001384952.1 → NP_001371881.1  protein NLRC5 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 6, encodes isoform 3.
      Source sequence(s)
      AC009090, AC023825
      Conserved Domains (6) summary
      sd00033
      Location:1523 → 1544
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1464 → 1494
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1521 → 1821
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    5. NM_001384953.1 → NP_001371882.1  protein NLRC5 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 5, encodes isoform 3.
      Source sequence(s)
      AC009090, AC023825
      Conserved Domains (6) summary
      sd00033
      Location:1523 → 1544
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1464 → 1494
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1521 → 1821
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    6. NM_001384954.1 → NP_001371883.1  protein NLRC5 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC009090, AC023825
      Conserved Domains (6) summary
      sd00033
      Location:1496 → 1517
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1437 → 1467
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1494 → 1794
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    7. NM_001384955.1 → NP_001371884.1  protein NLRC5 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC009090, AC023825
      Conserved Domains (6) summary
      sd00033
      Location:1495 → 1516
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1436 → 1466
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1493 → 1793
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    8. NM_001384956.1 → NP_001371885.1  protein NLRC5 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC009090, AC023825
      Conserved Domains (6) summary
      sd00033
      Location:1495 → 1516
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1436 → 1466
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1493 → 1793
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    9. NM_001384957.1 → NP_001371886.1  protein NLRC5 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC009090, AC023825
      Conserved Domains (6) summary
      sd00033
      Location:1494 → 1515
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1435 → 1465
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1492 → 1792
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    10. NM_001384958.1 → NP_001371887.1  protein NLRC5 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC009090, AC023825
      Conserved Domains (7) summary
      sd00033
      Location:1466 → 1487
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1407 → 1437
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cd21340
      Location:705 → 783
      PPP1R42; protein phosphatase 1 regulatory subunit 42
      cl39015
      Location:1464 → 1764
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    11. NM_001384959.1 → NP_001371888.1  protein NLRC5 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC009090, AC023825
      Conserved Domains (7) summary
      sd00033
      Location:1465 → 1486
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1406 → 1436
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cd21340
      Location:705 → 783
      PPP1R42; protein phosphatase 1 regulatory subunit 42
      cl39015
      Location:1463 → 1763
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    12. NM_001384960.1 → NP_001371889.1  protein NLRC5 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC009090, AC023825
      Conserved Domains (6) summary
      sd00033
      Location:1493 → 1520
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1383 → 1405
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1447 → 1735
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    13. NM_001384961.1 → NP_001371890.1  protein NLRC5 isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variant 15, encodes isoform 11.
      Source sequence(s)
      AC023825
      UniProtKB/TrEMBL
      H0YGE2
      Conserved Domains (5) summary
      sd00033
      Location:716 → 743
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:690 → 1069
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    14. NM_001384962.1 → NP_001371891.1  protein NLRC5 isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variant 14, encodes isoform 11.
      Source sequence(s)
      AC023825
      UniProtKB/TrEMBL
      H0YGE2
      Conserved Domains (5) summary
      sd00033
      Location:716 → 743
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:690 → 1069
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    15. NM_001384963.1 → NP_001371892.1  protein NLRC5 isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variant 17, encodes isoform 12.
      Source sequence(s)
      AC023825
      UniProtKB/TrEMBL
      H0YGE2
      Conserved Domains (5) summary
      sd00033
      Location:716 → 743
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:690 → 1069
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    16. NM_001384964.1 → NP_001371893.1  protein NLRC5 isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variant 16, encodes isoform 12.
      Source sequence(s)
      AC023825
      UniProtKB/TrEMBL
      H0YGE2
      Conserved Domains (5) summary
      sd00033
      Location:716 → 743
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:690 → 1069
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    17. NM_001384965.1 → NP_001371894.1  protein NLRC5 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC023825
      UniProtKB/TrEMBL
      H0YGE2
      Conserved Domains (5) summary
      sd00033
      Location:688 → 715
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:819 → 1040
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    18. NM_001384966.1 → NP_001371895.1  protein NLRC5 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC023825
      UniProtKB/TrEMBL
      H0YGE2
      Conserved Domains (5) summary
      sd00033
      Location:716 → 743
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:690 → 1069
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    19. NM_001384967.1 → NP_001371896.1  protein NLRC5 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC023825
      UniProtKB/TrEMBL
      H0YGE2
      Conserved Domains (5) summary
      sd00033
      Location:716 → 743
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:690 → 1069
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    20. NM_001384968.1 → NP_001371897.1  protein NLRC5 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC023825
      UniProtKB/TrEMBL
      H0YGE2
      Conserved Domains (5) summary
      sd00033
      Location:716 → 743
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:690 → 1069
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    21. NM_001384969.1 → NP_001371898.1  protein NLRC5 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC023825
      UniProtKB/TrEMBL
      H0YGE2
      Conserved Domains (5) summary
      sd00033
      Location:716 → 743
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:690 → 1069
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    22. NM_001384970.1 → NP_001371899.1  protein NLRC5 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC023825
      UniProtKB/TrEMBL
      H0YGE2
      Conserved Domains (5) summary
      sd00033
      Location:716 → 743
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:690 → 1069
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    23. NM_001384971.1 → NP_001371900.1  protein NLRC5 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC023825
      UniProtKB/TrEMBL
      H0YGE2
      Conserved Domains (5) summary
      sd00033
      Location:716 → 743
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:690 → 1069
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    24. NM_001384972.1 → NP_001371901.1  protein NLRC5 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC023825
      UniProtKB/TrEMBL
      H0YGE2
      Conserved Domains (5) summary
      sd00033
      Location:659 → 686
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:205 → 326
      NACHT; NACHT domain
      pfam17776
      Location:457 → 571
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:633 → 989
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    25. NM_001384973.1 → NP_001371902.1  protein NLRC5 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC023825
      Conserved Domains (6) summary
      sd00033
      Location:716 → 743
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cd21340
      Location:705 → 783
      PPP1R42; protein phosphatase 1 regulatory subunit 42
      cl39015
      Location:745 → 1069
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    26. NM_032206.5 → NP_115582.4  protein NLRC5 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AC009090, AC023825
      Consensus CDS
      CCDS10773.1
      UniProtKB/Swiss-Prot
      B5MEF1, C9JMD8, Q6P4A6, Q86VM7, Q86WI3, Q8NF42, Q8TEE2, Q8TEJ1, Q969L7
      Related
      ENSP00000262510.6, ENST00000262510.10
      Conserved Domains (6) summary
      sd00033
      Location:1524 → 1545
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1465 → 1495
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain
      pfam17776
      Location:514 → 628
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam18461
      Location:1 → 95
      Atypical_Card; Atypical caspase recruitment domain
      cl39015
      Location:1522 → 1822
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RNA

    1. NR_169512.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC009090, AC023825

    2. NR_169513.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC009090, AC023825

    3. NR_169514.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC023825

    4. NR_169515.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC009090, AC023825

    5. NR_169516.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC009090, AC023825

    6. NR_169517.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC009090, AC023825
      Related
      ENST00000545081.5

    7. NR_169518.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC009090, AC023825

    8. NR_169519.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC009090, AC023825

    9. NR_169520.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC009090, AC023825

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      56989557..57083520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434762.1 → XP_047290718.1  protein NLRC5 isoform X3

    2. XM_047434763.1 → XP_047290719.1  protein NLRC5 isoform X4

    3. XM_047434760.1 → XP_047290716.1  protein NLRC5 isoform X1

    4. XM_047434761.1 → XP_047290717.1  protein NLRC5 isoform X2

    5. XM_047434764.1 → XP_047290720.1  protein NLRC5 isoform X5

    6. XM_006721300.3 → XP_006721363.1  protein NLRC5 isoform X7

      UniProtKB/TrEMBL
      H0YGE2
      Conserved Domains (5) summary
      smart00382
      Location:221 → 365
      AAA; ATPases associated with a variety of cellular activities
      COG4886
      Location:731 → 936
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:690 → 1069
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:716 → 743
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:222 → 383
      NACHT; NACHT domain

    7. XM_047434765.1 → XP_047290721.1  protein NLRC5 isoform X7

      UniProtKB/TrEMBL
      H0YGE2

    8. XM_017023770.2 → XP_016879259.1  protein NLRC5 isoform X6

      UniProtKB/TrEMBL
      H0YGE2
      Related
      ENSP00000442906.1, ENST00000538805.5

    9. XM_047434766.1 → XP_047290722.1  protein NLRC5 isoform X8

      UniProtKB/TrEMBL
      H0YGE2

    RNA

    1. XR_001752000.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      62785869..62879790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314144.1 → XP_054170119.1  protein NLRC5 isoform X3

    2. XM_054314145.1 → XP_054170120.1  protein NLRC5 isoform X4

    3. XM_054314142.1 → XP_054170117.1  protein NLRC5 isoform X1

    4. XM_054314143.1 → XP_054170118.1  protein NLRC5 isoform X2

    5. XM_054314146.1 → XP_054170121.1  protein NLRC5 isoform X5

    6. XM_054314148.1 → XP_054170123.1  protein NLRC5 isoform X7

      UniProtKB/TrEMBL
      H0YGE2

    7. XM_054314149.1 → XP_054170124.1  protein NLRC5 isoform X7

      UniProtKB/TrEMBL
      H0YGE2

    8. XM_054314147.1 → XP_054170122.1  protein NLRC5 isoform X6

      UniProtKB/TrEMBL
      H0YGE2

    9. XM_054314150.1 → XP_054170125.1  protein NLRC5 isoform X8

      UniProtKB/TrEMBL
      H0YGE2

    RNA

    1. XR_008484741.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86WI3.3 GenPept UniProtKB/Swiss-Prot:Q86WI3

    Gene LinkOut

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