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    RLF RLF zinc finger [ Homo sapiens (human) ]

    Gene ID: 6018, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RLFprovided by HGNC
    Official Full Name
    RLF zinc fingerprovided by HGNC
    Primary source
    HGNC:HGNC:10025
    See related
    Ensembl:ENSG00000117000 MIM:180610; AllianceGenome:HGNC:10025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZN-15L; ZNF292L
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of heterochromatin formation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 13.7), testis (RPKM 7.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RLF in Genome Data Viewer
    Location:
    1p34.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (40161387..40240921)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (40030849..40110388)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40627059..40706593)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40598557-40599056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 830 Neighboring gene OAZ1 pseudogene 1 Neighboring gene uncharacterized LOC105378671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 831 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 721 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:40625521-40625722 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40626731-40627347 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40627348-40627963 Neighboring gene RNA, U6 small nuclear 1237, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 833 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 837 Neighboring gene transmembrane and coiled-coil domains 2 Neighboring gene zinc metallopeptidase STE24 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 838

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Intrachromosomal rearrangements fusing L-myc and rlf in small-cell lung cancer. Mäkelä TP, et al. Mol Cell Biol, 1991 Aug. PMID 1649386, Free PMC Article
    2. A fusion protein formed by L-myc and a novel gene in SCLC. Mäkelä TP, et al. EMBO J, 1991 Jun. PMID 1851085, Free PMC Article
    3. The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein. Mäkelä TP, et al. Oncogene, 1995 Dec 21. PMID 8545128
    4. Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. Lanigan TM, et al. FASEB J, 2003 Nov. PMID 14597674
    5. A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions. Swick L, et al. J Neurochem, 2006 Jun. PMID 16696853, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag The interaction of HIV-1 CA with human cellular rearranged L-myc fusion protein (RLF) is identified by yeast two-hybrid screen PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC142226

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein Rlf
    Names
    Zn-15 related
    rearranged L-myc fusion gene protein
    rearranged L-myc fusion sequence
    zn-15-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012421.4 → NP_036553.2  zinc finger protein Rlf

      See identical proteins and their annotated locations for NP_036553.2

      Status: VALIDATED

      Source sequence(s)
      BC113666, BM542854
      Consensus CDS
      CCDS448.1
      UniProtKB/Swiss-Prot
      Q13129, Q14CQ1, Q9NU60
      UniProtKB/TrEMBL
      Q59GL0
      Related
      ENSP00000361857.4, ENST00000372771.5
      Conserved Domains (2) summary
      COG5236
      Location:645 → 832
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:716 → 736
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      40161387..40240921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427055.1 → XP_047283011.1  zinc finger protein Rlf isoform X1

      UniProtKB/TrEMBL
      Q59GL0

    2. XM_047427057.1 → XP_047283013.1  zinc finger protein Rlf isoform X2

      UniProtKB/TrEMBL
      Q59GL0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      40030849..40110388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338052.1 → XP_054194027.1  zinc finger protein Rlf isoform X1

      UniProtKB/TrEMBL
      Q59GL0

    2. XM_054338053.1 → XP_054194028.1  zinc finger protein Rlf isoform X2

      UniProtKB/TrEMBL
      Q59GL0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13129.2 GenPept UniProtKB/Swiss-Prot:Q13129

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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