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    PWRN2 Prader-Willi region non-protein coding RNA 2 [ Homo sapiens (human) ]

    Gene ID: 791115, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PWRN2provided by HGNC
    Official Full Name
    Prader-Willi region non-protein coding RNA 2provided by HGNC
    Primary source
    HGNC:HGNC:33236
    See related
    Ensembl:ENSG00000260551 MIM:611217; AllianceGenome:HGNC:33236
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCRNA00199
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    Genomic context

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    See PWRN2 in Genome Data Viewer
    Location:
    15q11.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (24164777..24169948, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (21898852..21904023, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (24409924..24415095, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:24199761-24200274 Neighboring gene uncharacterized LOC107984787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:24200275-24200786 Neighboring gene Prader-Willi region non-protein coding RNA 4 Neighboring gene uncharacterized LOC105370733 Neighboring gene uncharacterized LOC105370732 Neighboring gene uncharacterized LOC102723749 Neighboring gene uncharacterized LOC102725165

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Long non-coding RNA PWRN2 regulates cytotoxicity in an in vitro model of age-related macular degeneration. Yu X, et al. Biochem Biophys Res Commun, 2021 Jan 8. PMID 33340764
    2. LncRNA PWRN2 stimulates the proliferation and migration in papillary thyroid carcinoma through the miR-325/DDX5 axis. Xin CH, et al. Eur Rev Med Pharmacol Sci, 2020 Oct. PMID 33090407
    3. Construction and analysis of a lncRNA (PWRN2)-mediated ceRNA network reveal its potential roles in oocyte nuclear maturation of patients with PCOS. Huang X, et al. Reprod Biol Endocrinol, 2018 Aug 3. PMID 30075721, Free PMC Article
    4. Precise microdeletion detection of Prader-Willi Syndrome with array comparative genome hybridization. Shao XY, et al. Biomed Environ Sci, 2010 Jun. PMID 20708498
    5. C15orf2 and a novel noncoding transcript from the Prader-Willi/Angelman syndrome region show monoallelic expression in fetal brain. Buiting K, et al. Genomics, 2007 May. PMID 17337158

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA PWRN2 stimulates the proliferation and migration in papillary thyroid carcinoma through the miR-325/DDX5 axis.
      Title: LncRNA PWRN2 stimulates the proliferation and migration in papillary thyroid carcinoma through the miR-325/DDX5 axis.
    2. Long non-coding RNA PWRN2 regulates cytotoxicity in an in vitro model of age-related macular degeneration.
      Title: Long non-coding RNA PWRN2 regulates cytotoxicity in an in vitro model of age-related macular degeneration.
    3. Prader-Willi region nonprotein coding RNA 2 (PWRN2) was found to be associated with oocyte nuclear maturation in patients with polycystic ovary syndrome (PCOS) in contrast to that in normal patients.
      Title: Construction and analysis of a lncRNA (PWRN2)-mediated ceRNA network reveal its potential roles in oocyte nuclear maturation of patients with PCOS.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Clone Names

    • FLJ42137

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_152824.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC087474
      Related
      ENST00000567246.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      24164777..24169948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160017.1 Reference GRCh38.p14 PATCHES

      Range
      5112475..5117648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      21898852..21904023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_026647.1: Suppressed sequence

      Description
      NR_026647.1: This RefSeq was removed because currently there is insufficient support for this transcript.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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