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    PPBP pro-platelet basic protein [ Homo sapiens (human) ]

    Gene ID: 5473, updated on 9-Dec-2024

    Summary

    Official Symbol
    PPBPprovided by HGNC
    Official Full Name
    pro-platelet basic proteinprovided by HGNC
    Primary source
    HGNC:HGNC:9240
    See related
    Ensembl:ENSG00000163736 MIM:121010; AllianceGenome:HGNC:9240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PBP; TC1; TC2; TGB; LDGF; MDGF; TGB1; B-TG1; CTAP3; CXCL7; NAP-2; SCYB7; THBGB; LA-PF4; THBGB1; Beta-TG; CTAPIII; CTAP-III
    Summary
    The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014]
    Expression
    Biased expression in bone marrow (RPKM 35.8), spleen (RPKM 5.3) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PPBP in Genome Data Viewer
    Location:
    4q13.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (73986439..73988190, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (77330080..77331831, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (74852156..74853907, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene C-X-C motif chemokine ligand 1 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:74833595-74834096 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:74846696-74847437 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:74850560-74851073 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:74851074-74851586 Neighboring gene platelet factor 4 Neighboring gene uncharacterized LOC124900715 Neighboring gene C-X-C motif chemokine ligand 5 Neighboring gene RNA, 7SL, cytoplasmic 218, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef specifically incorporates CSF2, PPBP (NAP2), CCL5, TNF, FAS, CXCL1, IL12B, MIF and OSM into plasma extracellular vesicles from HIV-1 infected patient samples PubMed
    retropepsin gag-pol Connective tissue-activating peptide (CTAPIII) and neutrophil-activating peptide 2 (NAP/2) are generated by digestion of a ubiquitin-CTAPIII conjugate with yeast ubiquitin C-terminal hydrolase (YUH1) and HIV protease, respectively PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CXCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables D-glucose transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in platelet alpha granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in tertiary granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    platelet basic protein
    Names
    C-X-C motif chemokine 7
    CXC chemokine ligand 7
    beta-thromboglobulin
    chemokine (C-X-C motif) ligand 7
    connective tissue-activating peptide III
    leukocyte-derived growth factor
    low-affinity platelet factor IV
    macrophage-derived growth factor
    neutrophil-activating peptide 2
    small inducible cytokine B7
    small inducible cytokine subfamily B, member 7
    thrombocidin 1
    thrombocidin 2
    thromboglobulin, beta-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002704.3NP_002695.1  platelet basic protein preproprotein

      See identical proteins and their annotated locations for NP_002695.1

      Status: REVIEWED

      Source sequence(s)
      AC097709, DA419455
      Consensus CDS
      CCDS3563.1
      UniProtKB/Swiss-Prot
      B2R5F3, P02775, Q6IBJ8
      UniProtKB/TrEMBL
      D3JV41
      Related
      ENSP00000296028.3, ENST00000296028.4
      Conserved Domains (1) summary
      cd00273
      Location:60122
      Chemokine_CXC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      73986439..73988190 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      77330080..77331831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)