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    SLC13A4 solute carrier family 13 member 4 [ Homo sapiens (human) ]

    Gene ID: 26266, updated on 4-Jan-2025

    Summary

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    Official Symbol
    SLC13A4provided by HGNC
    Official Full Name
    solute carrier family 13 member 4provided by HGNC
    Primary source
    HGNC:HGNC:15827
    See related
    Ensembl:ENSG00000164707 MIM:604309; AllianceGenome:HGNC:15827
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NAS2; SUT1; SUT-1
    Summary
    Enables sodium:sulfate symporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in placenta (RPKM 28.4) and testis (RPKM 3.0) See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC13A4 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (135681231..135728186, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (136988529..137035495, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (135365979..135412934, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18680 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:135347996-135348520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:135348521-135349045 Neighboring gene Sharpr-MPRA regulatory region 4311 Neighboring gene ribosomal protein L15 pseudogene 11 Neighboring gene RNA, U6 small nuclear 1154, pseudogene Neighboring gene short transmembrane mitochondrial protein 1 Neighboring gene uncharacterized LOC105375521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:135381445-135382158 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:135382159-135382872 Neighboring gene Sharpr-MPRA regulatory region 13285 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:135399353-135400219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:135418827-135419327 Neighboring gene family with sequence similarity 180 member A Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:135429999-135431198 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:135437647-135438562 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:135438563-135439478 Neighboring gene uncharacterized LOC105375522

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. SLC13A4 Might Serve as a Prognostic Biomarker and be Correlated with Immune Infiltration into Head and Neck Squamous Cell Carcinoma. Yang ML, et al. Pathol Oncol Res, 2021. PMID 34840533, Free PMC Article
    2. Molecular analysis of sequence and splice variants of the human SLC13A4 sulfate transporter. Zhang Z, et al. Mol Genet Metab, 2017 May. PMID 28385533
    3. Molecular analysis of the human SLC13A4 sulfate transporter gene promoter. Jefferis J, et al. Biochem Biophys Res Commun, 2013 Mar 29. PMID 23485456
    4. Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4). Markovich D, et al. Biochem Biophys Res Commun, 2005 Jan 28. PMID 15607730
    5. Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules. Girard JP, et al. Proc Natl Acad Sci U S A, 1999 Oct 26. PMID 10535998, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC13A4 Might Serve as a Prognostic Biomarker and be Correlated with Immune Infiltration into Head and Neck Squamous Cell Carcinoma.
      Title: SLC13A4 Might Serve as a Prognostic Biomarker and be Correlated with Immune Infiltration into Head and Neck Squamous Cell Carcinoma.
    2. Study found that despite differential expression of the two SLC13A4 transcripts, no detectable functional difference in the cellular sorting or sulfate transporting was found. However, some variants can influence both mechanism in specific cell membranes. This is like to have clinical implications based on the consequences of impaired sulfate transport during pregnancy in rodent models.
      Title: Molecular analysis of sequence and splice variants of the human SLC13A4 sulfate transporter.
    3. SLC13A4 and SLC26A2 were the most abundant sulfate transporter mRNAs, which localized to syncytiotrophoblast and cytotrophoblast cells, respectively.
      Title: Human placental sulfate transporter mRNA profiling from term pregnancies identifies abundant SLC13A4 in syncytiotrophoblasts and SLC26A2 in cytotrophoblasts.
    4. To investigate the regulation of SLC13A4 gene expression, we analysed the transcriptional activity of the SLC13A4 5'-flanking region in the JEG-3 placental cell line using luciferase reporter assays.
      Title: Molecular analysis of the human SLC13A4 sulfate transporter gene promoter.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    6. Here, we characterized the functional properties of the human Na(+)-sulfate cotransporter (hNaS2), determined its tissue distribution, and identified its gene (SLC13A4) structure.
      Title: Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4).
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sodium:sulfate symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium:sulfate symporter activity TAS
    Traceable Author Statement
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate transmembrane transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 13 member 4
    Names
    Na(+)/sulfate cotransporter SUT-1
    solute carrier family 13 (sodium/sulfate symporter), member 4
    solute carrier family 13 (sodium/sulfate symporters), member 4
    solute carrier family 13 (sodium/sulphate symporters), member 4
    sulphate transporter 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318192.2 → NP_001305121.1  solute carrier family 13 member 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB208809, AC091736, AF169301, BC030689
      Consensus CDS
      CCDS94210.1
      UniProtKB/TrEMBL
      A0A804HKQ4, A0AAQ5BH36, V9GYC7, V9GZ66
      Related
      ENSP00000508027.1, ENST00000682651.1
      Conserved Domains (2) summary
      cd01115
      Location:38 → 605
      SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...
      TIGR00785
      Location:40 → 604
      dass; anion transporter

    2. NM_012450.4 → NP_036582.2  solute carrier family 13 member 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB208809, AC091736, AF169301, BC030689
      Consensus CDS
      CCDS5840.1
      UniProtKB/Swiss-Prot
      A4D1Q4, Q8N631, Q9UKG4
      UniProtKB/TrEMBL
      A0AAQ5BH36
      Related
      ENSP00000297282.5, ENST00000354042.8
      Conserved Domains (1) summary
      cd01115
      Location:38 → 604
      SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      135681231..135728186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420184.1 → XP_047276140.1  solute carrier family 13 member 4 isoform X2

      UniProtKB/TrEMBL
      A0AAQ5BH36

    2. XM_011516024.4 → XP_011514326.1  solute carrier family 13 member 4 isoform X1

      UniProtKB/TrEMBL
      A0AAQ5BH36
      Conserved Domains (1) summary
      cl21473
      Location:32 → 570
      ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...

    3. XM_017011962.2 → XP_016867451.1  solute carrier family 13 member 4 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      136988529..137035495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357863.1 → XP_054213838.1  solute carrier family 13 member 4 isoform X2

      UniProtKB/TrEMBL
      A0AAQ5BH36

    2. XM_054357862.1 → XP_054213837.1  solute carrier family 13 member 4 isoform X1

      UniProtKB/TrEMBL
      A0AAQ5BH36

    3. XM_054357864.1 → XP_054213839.1  solute carrier family 13 member 4 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UKG4.2 GenPept UniProtKB/Swiss-Prot:Q9UKG4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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